{
  "url": "https://dantelabs.com/ro/genes/eda",
  "gene": {
    "slug": "eda",
    "symbol": "EDA",
    "name": "ectodysplasin A",
    "hgnc": "HGNC:3157",
    "summary": null,
    "location": "Xq13.1",
    "locusType": "gene with protein product",
    "aliases": [
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      "XLHED",
      "HED",
      "XHED",
      "ED1-A1",
      "ED1-A2",
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      "EDA-A2"
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    "previousSymbols": [
      "ED1",
      "EDA2",
      "ODT1"
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    "ensemblId": "ENSG00000158813",
    "entrezId": 1896,
    "omim": [
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    "uniprot": [
      "Q92838"
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      "release": "v1.5",
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      "start": 69616113,
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      "strand": "+",
      "ensemblTranscript": "ENST00000374552.9",
      "refseqTranscript": "NM_001399.5",
      "ensemblProtein": "ENSP00000363680.4",
      "refseqProtein": "NP_001390.1",
      "exons": [
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      ],
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    },
    "grch37": {
      "build": "GRCh37",
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      "chrom": "X",
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      "end": 69259319,
      "strand": "+"
    },
    "neighbourhood": {
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      "genes": [
        {
          "symbol": "NALF2",
          "ensemblId": "ENSG00000130054",
          "biotype": "protein_coding",
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          "end": 69532508,
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          "slug": "nalf2"
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        {
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          "end": 70049988,
          "strand": "-",
          "slug": "awat2"
        },
        {
          "symbol": "OTUD6A",
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          "biotype": "protein_coding",
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          "strand": "+",
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        {
          "symbol": "IGBP1",
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          "slug": "igbp1"
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        {
          "symbol": "DGAT2L6",
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          "biotype": "protein_coding",
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        {
          "symbol": "PDZD11",
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          "biotype": "protein_coding",
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          "end": 70290596,
          "strand": "-",
          "slug": "pdzd11"
        },
        {
          "symbol": "AWAT1",
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          "biotype": "protein_coding",
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        },
        {
          "symbol": "P2RY4",
          "ensemblId": "ENSG00000186912",
          "biotype": "protein_coding",
          "start": 70258166,
          "end": 70260204,
          "strand": "-",
          "slug": "p2ry4"
        },
        {
          "symbol": "ARR3",
          "ensemblId": "ENSG00000120500",
          "biotype": "protein_coding",
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          "strand": "+",
          "slug": "arr3"
        },
        {
          "symbol": "RAB41",
          "ensemblId": "ENSG00000147127",
          "biotype": "protein_coding",
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          "strand": "+",
          "slug": "rab41"
        },
        {
          "symbol": "KIF4A",
          "ensemblId": "ENSG00000090889",
          "biotype": "protein_coding",
          "start": 70290021,
          "end": 70420924,
          "strand": "+",
          "slug": "kif4a"
        },
        {
          "symbol": "GDPD2",
          "ensemblId": "ENSG00000130055",
          "biotype": "protein_coding",
          "start": 70423031,
          "end": 70433710,
          "strand": "+",
          "slug": "gdpd2"
        },
        {
          "symbol": "DLG3",
          "ensemblId": "ENSG00000082458",
          "biotype": "protein_coding",
          "start": 70444793,
          "end": 70505490,
          "strand": "+",
          "slug": "dlg3"
        }
      ],
      "truncated": false
    },
    "reports": [
      {
        "slug": "ectodermal-dysplasias",
        "name": "Displazii ectodermice",
        "diseases": [
          {
            "mondoId": "MONDO:0016535",
            "name": "Displazie ectodermică hipohidrotică",
            "genes": 5,
            "inheritance": null,
            "description": "O tulburare genetică a dezvoltării ectodermului, caracterizată prin malformarea structurilor ectodermice, cum sunt pielea, părul, dinții și glandele sudoripare. Include trei subtipuri aproape imposibil de distins clinic, având drept simptom principal transpirația afectată: sindromul Christ-Siemens-Touraine (CST) (legat de cromozomul X), DEH autozomal recesiv (AR) și DEH autozomal dominant (AD), precum și un al patrulea subtip rar, având drept simptom principal imunodeficiența (DEH cu imunodeficiență).",
            "management": null,
            "evidence": {
              "gencc": [
                "G2P",
                "Labcorp Genetics (formerly Invitae)",
                "Natera",
                "PanelApp Australia"
              ],
              "acmgSf": false,
              "inheritance": [
                "x-linked-recessive"
              ]
            },
            "sameAsReport": false,
            "broad": false
          }
        ],
        "url": "https://dantelabs.com/ro/conditions/ectodermal-dysplasias"
      },
      {
        "slug": "hypodontia-and-anodontia",
        "name": "Hipodonție și anodonție",
        "diseases": [
          {
            "mondoId": "MONDO:0005486",
            "name": "Agenezia dentară (hipodonție)",
            "genes": 7,
            "inheritance": null,
            "description": null,
            "management": null,
            "evidence": {
              "gencc": [
                "G2P",
                "Labcorp Genetics (formerly Invitae)"
              ],
              "acmgSf": false,
              "inheritance": []
            },
            "sameAsReport": false,
            "broad": false
          }
        ],
        "url": "https://dantelabs.com/ro/conditions/hypodontia-and-anodontia"
      }
    ],
    "pharmacogenomics": [],
    "traits": [],
    "phenotypes": [
      {
        "slug": "abnormal-canine-tooth-morphology",
        "name": "Abnormality of canine",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/abnormal-canine-tooth-morphology"
      },
      {
        "slug": "abnormal-dental-morphology",
        "name": "Abnormality of dental shape",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/abnormal-dental-morphology"
      },
      {
        "slug": "abnormal-oral-mucosa-morphology",
        "name": "Abnormality of lining of mouth",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "url": "https://dantelabs.com/traits/abnormal-oral-mucosa-morphology"
      },
      {
        "slug": "abnormal-primary-molar-morphology",
        "name": "Abnormality of shape of baby molar",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/abnormal-primary-molar-morphology"
      },
      {
        "slug": "selective-tooth-agenesis",
        "name": "Absence of a tooth",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "url": "https://dantelabs.com/traits/selective-tooth-agenesis"
      },
      {
        "slug": "agenesis-of-mandibular-premolar",
        "name": "Absence of lower premolar",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/agenesis-of-mandibular-premolar"
      },
      {
        "slug": "agenesis-of-molar",
        "name": "Absence of molar",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/agenesis-of-molar"
      },
      {
        "slug": "agenesis-of-premolar",
        "name": "Absence of premolar",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/agenesis-of-premolar"
      },
      {
        "slug": "agenesis-of-first-permanent-molar-tooth",
        "name": "Absence of six year molar",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/agenesis-of-first-permanent-molar-tooth"
      },
      {
        "slug": "aplasia-of-the-maxilla",
        "name": "Absence of upper jaw bones",
        "systems": [
          "abnormality-of-head-or-neck",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/aplasia-of-the-maxilla"
      },
      {
        "slug": "agenesis-of-maxillary-lateral-incisor",
        "name": "Absence of upper lateral incisor",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/agenesis-of-maxillary-lateral-incisor"
      },
      {
        "slug": "agenesis-of-central-incisor",
        "name": "Absent central incisor",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/agenesis-of-central-incisor"
      },
      {
        "slug": "absent-eyebrow",
        "name": "Absent eyebrow",
        "systems": [
          "abnormality-of-head-or-neck",
          "abnormality-of-the-integument"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/absent-eyebrow"
      },
      {
        "slug": "absent-eyelashes",
        "name": "Absent eyelashes",
        "systems": [
          "abnormality-of-head-or-neck",
          "abnormality-of-the-integument"
        ],
        "url": "https://dantelabs.com/traits/absent-eyelashes"
      },
      {
        "slug": "absent-nipple",
        "name": "Absent nipple",
        "systems": [
          "abnormality-of-the-breast"
        ],
        "url": "https://dantelabs.com/traits/absent-nipple"
      },
      {
        "slug": "anterior-hypopituitarism",
        "name": "Anterior hypopituitarism",
        "systems": [
          "abnormality-of-the-endocrine-system",
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/anterior-hypopituitarism"
      },
      {
        "slug": "aplasia-hypoplasia-of-the-eccrine-sweat-glands",
        "name": "Aplasia/Hypoplasia of the eccrine sweat glands",
        "systems": [
          "abnormality-of-the-integument"
        ],
        "url": "https://dantelabs.com/traits/aplasia-hypoplasia-of-the-eccrine-sweat-glands"
      },
      {
        "slug": "dental-malocclusion",
        "name": "Bad bite",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/dental-malocclusion"
      },
      {
        "slug": "respiratory-distress",
        "name": "Breathing difficulties",
        "systems": [
          "abnormality-of-the-respiratory-system"
        ],
        "url": "https://dantelabs.com/traits/respiratory-distress"
      },
      {
        "slug": "brittle-hair",
        "name": "Brittle hair",
        "systems": [
          "abnormality-of-the-integument"
        ],
        "url": "https://dantelabs.com/traits/brittle-hair"
      },
      {
        "slug": "impaired-mastication",
        "name": "Chewing difficulties",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/impaired-mastication"
      },
      {
        "slug": "orofacial-cleft",
        "name": "Cleft of the mouth",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/orofacial-cleft"
      },
      {
        "slug": "conical-tooth",
        "name": "Cone shaped tooth",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "url": "https://dantelabs.com/traits/conical-tooth"
      },
      {
        "slug": "constipation",
        "name": "Constipation",
        "systems": [
          "abnormality-of-the-digestive-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/constipation"
      },
      {
        "slug": "periorbital-hyperpigmentation",
        "name": "Dark circles around the eyes",
        "systems": [
          "abnormality-of-head-or-neck",
          "abnormality-of-the-integument"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/periorbital-hyperpigmentation"
      },
      {
        "slug": "hypohidrosis",
        "name": "Decreased ability to sweat",
        "systems": [
          "abnormality-of-the-integument"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/hypohidrosis"
      },
      {
        "slug": "short-dental-root",
        "name": "Decreased length of dental roots",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/short-dental-root"
      },
      {
        "slug": "tooth-agenesis",
        "name": "Decreased number of teeth",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "url": "https://dantelabs.com/traits/tooth-agenesis"
      },
      {
        "slug": "hypoplasia-of-the-maxilla",
        "name": "Decreased size of maxilla",
        "systems": [
          "abnormality-of-head-or-neck",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "url": "https://dantelabs.com/traits/hypoplasia-of-the-maxilla"
      },
      {
        "slug": "hypoplasia-of-teeth",
        "name": "Decreased size of teeth",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/hypoplasia-of-teeth"
      },
      {
        "slug": "microdontia",
        "name": "Decreased size of tooth",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/microdontia"
      },
      {
        "slug": "delayed-eruption-of-permanent-teeth",
        "name": "Delayed eruption of permanent teeth",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/delayed-eruption-of-permanent-teeth"
      },
      {
        "slug": "delayed-eruption-of-teeth",
        "name": "Delayed eruption of teeth",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/delayed-eruption-of-teeth"
      },
      {
        "slug": "depressed-nasal-bridge",
        "name": "Depressed nasal bridge",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/depressed-nasal-bridge"
      },
      {
        "slug": "everted-lower-lip-vermilion",
        "name": "Drooping lower lip",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/everted-lower-lip-vermilion"
      },
      {
        "slug": "everted-upper-lip-vermilion",
        "name": "Drooping upper lip",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/everted-upper-lip-vermilion"
      },
      {
        "slug": "dry-skin",
        "name": "Dry skin",
        "systems": [
          "abnormality-of-the-integument"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/dry-skin"
      },
      {
        "slug": "eczematoid-dermatitis",
        "name": "Eczema",
        "systems": [
          "abnormality-of-the-immune-system",
          "abnormality-of-the-integument"
        ],
        "url": "https://dantelabs.com/traits/eczematoid-dermatitis"
      },
      {
        "slug": "anodontia",
        "name": "Failure of development of all teeth",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "url": "https://dantelabs.com/traits/anodontia"
      },
      {
        "slug": "hypodontia",
        "name": "Failure of development of between one and six teeth",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/hypodontia"
      },
      {
        "slug": "oligodontia",
        "name": "Failure of development of more than six teeth",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/oligodontia"
      },
      {
        "slug": "fever",
        "name": "Fever",
        "systems": [
          "abnormality-of-metabolism-homeostasis"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/fever"
      },
      {
        "slug": "fine-hair",
        "name": "Fine hair",
        "systems": [
          "abnormality-of-the-integument"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/fine-hair"
      },
      {
        "slug": "depressed-nasal-ridge",
        "name": "Flat nose",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/depressed-nasal-ridge"
      },
      {
        "slug": "frontal-bossing",
        "name": "Frontal bossing",
        "systems": [
          "abnormality-of-head-or-neck",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/frontal-bossing"
      },
      {
        "slug": "thick-vermilion-border",
        "name": "Full lips",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/thick-vermilion-border"
      },
      {
        "slug": "heat-intolerance",
        "name": "Heat intolerance",
        "systems": [
          "abnormality-of-metabolism-homeostasis"
        ],
        "url": "https://dantelabs.com/traits/heat-intolerance"
      },
      {
        "slug": "hypertension",
        "name": "High blood pressure",
        "systems": [
          "abnormality-of-the-cardiovascular-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/hypertension"
      },
      {
        "slug": "hoarse-voice",
        "name": "Hoarse voice",
        "systems": [
          "abnormality-of-the-voice"
        ],
        "url": "https://dantelabs.com/traits/hoarse-voice"
      },
      {
        "slug": "hypoplastic-absent-sebaceous-glands",
        "name": "Hypoplastic-absent sebaceous glands",
        "systems": [
          "abnormality-of-the-integument"
        ],
        "url": "https://dantelabs.com/traits/hypoplastic-absent-sebaceous-glands"
      },
      {
        "slug": "dysphonia",
        "name": "Inability to produce voice sounds",
        "systems": [
          "abnormality-of-the-voice"
        ],
        "url": "https://dantelabs.com/traits/dysphonia"
      },
      {
        "slug": "anhidrosis",
        "name": "Lack of sweating",
        "systems": [
          "abnormality-of-the-integument"
        ],
        "url": "https://dantelabs.com/traits/anhidrosis"
      },
      {
        "slug": "agenesis-of-lateral-incisor",
        "name": "Missing lateral incisor",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/agenesis-of-lateral-incisor"
      },
      {
        "slug": "rhinitis",
        "name": "Nasal inflammation",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "url": "https://dantelabs.com/traits/rhinitis"
      },
      {
        "slug": "eclabion",
        "name": "Outward turned lips",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/eclabion"
      },
      {
        "slug": "peg-shaped-maxillary-lateral-incisors",
        "name": "Peg-shaped maxillary lateral incisors",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/peg-shaped-maxillary-lateral-incisors"
      },
      {
        "slug": "prominent-supraorbital-ridges",
        "name": "Prominent brow",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "url": "https://dantelabs.com/traits/prominent-supraorbital-ridges"
      },
      {
        "slug": "prominent-forehead",
        "name": "Prominent forehead",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/prominent-forehead"
      },
      {
        "slug": "short-chin",
        "name": "Short chin",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "url": "https://dantelabs.com/traits/short-chin"
      },
      {
        "slug": "short-face",
        "name": "Short face",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/short-face"
      },
      {
        "slug": "short-nose",
        "name": "Short nose",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "url": "https://dantelabs.com/traits/short-nose"
      },
      {
        "slug": "short-distal-phalanx-of-finger",
        "name": "Short outermost finger bone",
        "systems": [
          "abnormality-of-limbs",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/short-distal-phalanx-of-finger"
      },
      {
        "slug": "hypoplastic-nipples",
        "name": "Small nipples",
        "systems": [
          "abnormality-of-the-breast"
        ],
        "url": "https://dantelabs.com/traits/hypoplastic-nipples"
      },
      {
        "slug": "soft-skin",
        "name": "Soft skin",
        "systems": [
          "abnormality-of-the-integument"
        ],
        "url": "https://dantelabs.com/traits/soft-skin"
      },
      {
        "slug": "sparse-body-hair",
        "name": "Sparse body hair",
        "systems": [
          "abnormality-of-the-integument"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/sparse-body-hair"
      },
      {
        "slug": "sparse-eyebrow",
        "name": "Sparse eyebrow",
        "systems": [
          "abnormality-of-head-or-neck",
          "abnormality-of-the-integument"
        ],
        "url": "https://dantelabs.com/traits/sparse-eyebrow"
      },
      {
        "slug": "sparse-eyelashes",
        "name": "Sparse eyelashes",
        "systems": [
          "abnormality-of-head-or-neck",
          "abnormality-of-the-integument"
        ],
        "url": "https://dantelabs.com/traits/sparse-eyelashes"
      },
      {
        "slug": "sparse-hair",
        "name": "Sparse hair",
        "systems": [
          "abnormality-of-the-integument"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/sparse-hair"
      },
      {
        "slug": "aplasia-hypoplasia-of-the-eyebrow",
        "name": "Sparse or absent eyebrows",
        "systems": [
          "abnormality-of-head-or-neck",
          "abnormality-of-the-integument"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/aplasia-hypoplasia-of-the-eyebrow"
      },
      {
        "slug": "concave-nail",
        "name": "Spoon-shaped nails",
        "systems": [
          "abnormality-of-the-integument"
        ],
        "url": "https://dantelabs.com/traits/concave-nail"
      },
      {
        "slug": "taurodontia",
        "name": "Taurodontia",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/taurodontia"
      },
      {
        "slug": "enamel-hypoplasia",
        "name": "Thin dental enamel",
        "systems": [
          "abnormality-of-head-or-neck",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/enamel-hypoplasia"
      },
      {
        "slug": "thin-skin",
        "name": "Thin skin",
        "systems": [
          "abnormality-of-the-integument"
        ],
        "url": "https://dantelabs.com/traits/thin-skin"
      },
      {
        "slug": "type-i-diabetes-mellitus",
        "name": "Type 1 diabetes",
        "systems": [
          "abnormality-of-metabolism-homeostasis",
          "abnormality-of-the-endocrine-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/type-i-diabetes-mellitus"
      },
      {
        "slug": "underdeveloped-nasal-alae",
        "name": "Underdeveloped tissue around nostril",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "url": "https://dantelabs.com/traits/underdeveloped-nasal-alae"
      },
      {
        "slug": "widely-spaced-teeth",
        "name": "Widely spaced teeth",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/widely-spaced-teeth"
      },
      {
        "slug": "periorbital-wrinkles",
        "name": "Wrinkles around the eyes",
        "systems": [
          "abnormality-of-head-or-neck",
          "abnormality-of-the-integument"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/periorbital-wrinkles"
      }
    ],
    "related": [
      {
        "slug": "edar",
        "symbol": "EDAR",
        "name": "ectodysplasin A receptor",
        "shared": 1,
        "url": "https://dantelabs.com/ro/genes/edar"
      },
      {
        "slug": "edaradd",
        "symbol": "EDARADD",
        "name": "EDAR associated via death domain",
        "shared": 1,
        "url": "https://dantelabs.com/ro/genes/edaradd"
      },
      {
        "slug": "ikbkg",
        "symbol": "IKBKG",
        "name": "inhibitor of nuclear factor kappa B kinase regulatory subunit gamma",
        "shared": 1,
        "url": "https://dantelabs.com/ro/genes/ikbkg"
      },
      {
        "slug": "lrp6",
        "symbol": "LRP6",
        "name": "LDL receptor related protein 6",
        "shared": 1,
        "url": "https://dantelabs.com/ro/genes/lrp6"
      },
      {
        "slug": "msx1",
        "symbol": "MSX1",
        "name": "msh homeobox 1",
        "shared": 1,
        "url": "https://dantelabs.com/ro/genes/msx1"
      },
      {
        "slug": "nfkbia",
        "symbol": "NFKBIA",
        "name": "NFKB inhibitor alpha",
        "shared": 1,
        "url": "https://dantelabs.com/ro/genes/nfkbia"
      },
      {
        "slug": "pax9",
        "symbol": "PAX9",
        "name": "paired box 9",
        "shared": 1,
        "url": "https://dantelabs.com/ro/genes/pax9"
      },
      {
        "slug": "tspear",
        "symbol": "TSPEAR",
        "name": "thrombospondin type laminin G domain and EAR repeats",
        "shared": 1,
        "url": "https://dantelabs.com/ro/genes/tspear"
      },
      {
        "slug": "wnt10a",
        "symbol": "WNT10A",
        "name": "Wnt family member 10A",
        "shared": 1,
        "url": "https://dantelabs.com/ro/genes/wnt10a"
      },
      {
        "slug": "wnt10b",
        "symbol": "WNT10B",
        "name": "Wnt family member 10B",
        "shared": 1,
        "url": "https://dantelabs.com/ro/genes/wnt10b"
      }
    ],
    "sources": {
      "bundleId": "2026.10.18-e609d43e",
      "panel": "2026-10-17",
      "acmgSf": "SF v3.2"
    },
    "locusKind": "proteinCoding"
  },
  "variants": {
    "total": 0,
    "url": null,
    "items": []
  }
}