{
  "url": "https://dantelabs.com/ro/genes/calm3",
  "gene": {
    "slug": "calm3",
    "symbol": "CALM3",
    "name": "calmodulin 3",
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    "locusType": "gene with protein product",
    "aliases": [
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      "PHKD3"
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    "uniprot": [
      "P0DP25"
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    },
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      "build": "GRCh37",
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    "neighbourhood": {
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        {
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        {
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        {
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        {
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        {
          "symbol": "PNMA8A",
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        {
          "symbol": "PNMA8B",
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        {
          "symbol": "PTGIR",
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          "symbol": "DACT3",
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        {
          "symbol": "PRKD2",
          "ensemblId": "ENSG00000105287",
          "biotype": "protein_coding",
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        {
          "symbol": "STRN4",
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          "biotype": "protein_coding",
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        {
          "symbol": "FKRP",
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          "biotype": "protein_coding",
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        },
        {
          "symbol": "SLC1A5",
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          "biotype": "protein_coding",
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          "slug": "slc1a5"
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        {
          "symbol": "AP2S1",
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          "biotype": "protein_coding",
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          "slug": "ap2s1"
        },
        {
          "symbol": "ARHGAP35",
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          "biotype": "protein_coding",
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          "slug": "arhgap35"
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        {
          "symbol": "NPAS1",
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          "biotype": "protein_coding",
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          "strand": "+",
          "slug": "npas1"
        },
        {
          "symbol": "TMEM160",
          "ensemblId": "ENSG00000130748",
          "biotype": "protein_coding",
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          "slug": "tmem160"
        },
        {
          "symbol": "ZC3H4",
          "ensemblId": "ENSG00000130749",
          "biotype": "protein_coding",
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          "strand": "-",
          "slug": "zc3h4"
        }
      ],
      "truncated": false
    },
    "reports": [
      {
        "slug": "catecholaminergic-polymorphic-ventricular-tachycardia",
        "name": "Tahicardie ventriculară polimorfă catecolaminergică",
        "diseases": [
          {
            "mondoId": "MONDO:0008648",
            "name": "Tahicardie ventriculară familială",
            "genes": 7,
            "inheritance": null,
            "description": "Un episod de tahicardie ventriculară cauzat de o modificare ereditară a genomului individului.",
            "management": null,
            "evidence": {
              "gencc": [
                "Genomics England PanelApp",
                "Labcorp Genetics (formerly Invitae)"
              ],
              "clingen": "Moderate",
              "acmgSf": true,
              "inheritance": [
                "autosomal-dominant"
              ],
              "actionability": 12
            },
            "sameAsReport": false,
            "broad": false
          },
          {
            "mondoId": "MONDO:0020575",
            "name": "Tahicardie ventriculară polimorfă",
            "genes": 7,
            "inheritance": null,
            "description": "O tahicardie ventriculară cu frecvență și ritm neregulate.",
            "management": null,
            "evidence": {
              "gencc": [
                "Genomics England PanelApp",
                "Labcorp Genetics (formerly Invitae)"
              ],
              "clingen": "Moderate",
              "acmgSf": true,
              "inheritance": [
                "autosomal-dominant"
              ],
              "actionability": 12
            },
            "sameAsReport": false,
            "broad": false
          }
        ],
        "url": "https://dantelabs.com/ro/conditions/catecholaminergic-polymorphic-ventricular-tachycardia"
      },
      {
        "slug": "long-qt-syndrome",
        "name": "Sindromul QT lung",
        "diseases": [
          {
            "mondoId": "MONDO:0002442",
            "name": "Sindromul QT lung",
            "genes": 10,
            "inheritance": null,
            "description": "O tulburare a repolarizării cardiace, caracterizată printr-un interval QT prelungit și printr-un risc de aritmii ventriculare periculoase, precum torsada vârfurilor.",
            "management": "Beta-blocante, implantarea unui ICD, restricționarea activității fizice, consiliere genetică",
            "evidence": {
              "gencc": [
                "ClinGen",
                "G2P",
                "Genomics England PanelApp",
                "Labcorp Genetics (formerly Invitae)"
              ],
              "clingen": "Definitive",
              "acmgSf": true,
              "inheritance": [
                "autosomal-dominant"
              ],
              "actionability": 12
            },
            "sameAsReport": true,
            "broad": false
          }
        ],
        "url": "https://dantelabs.com/ro/conditions/long-qt-syndrome"
      }
    ],
    "pharmacogenomics": [],
    "traits": [],
    "phenotypes": [
      {
        "slug": "patent-ductus-arteriosus-after-birth-at-term",
        "name": "Patent ductus arteriosus after birth at term",
        "systems": [
          "abnormality-of-the-cardiovascular-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/patent-ductus-arteriosus-after-birth-at-term"
      },
      {
        "slug": "perimembranous-ventricular-septal-defect",
        "name": "Perimembranous ventricular septal defect",
        "systems": [
          "abnormality-of-the-cardiovascular-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/perimembranous-ventricular-septal-defect"
      },
      {
        "slug": "prolonged-qtc-interval",
        "name": "Prolonged QTc interval",
        "systems": [
          "abnormality-of-the-cardiovascular-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/prolonged-qtc-interval"
      },
      {
        "slug": "second-degree-atrioventricular-block",
        "name": "Second degree atrioventricular block",
        "systems": [
          "abnormality-of-the-cardiovascular-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/second-degree-atrioventricular-block"
      },
      {
        "slug": "bradycardia",
        "name": "Slow heartbeats",
        "systems": [
          "abnormality-of-the-cardiovascular-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/bradycardia"
      },
      {
        "slug": "t-wave-alternans",
        "name": "T-wave alternans",
        "systems": [
          "abnormality-of-the-cardiovascular-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/t-wave-alternans"
      }
    ],
    "related": [
      {
        "slug": "calm1",
        "symbol": "CALM1",
        "name": "calmodulin 1",
        "shared": 3,
        "url": "https://dantelabs.com/ro/genes/calm1"
      },
      {
        "slug": "calm2",
        "symbol": "CALM2",
        "name": "calmodulin 2",
        "shared": 3,
        "url": "https://dantelabs.com/ro/genes/calm2"
      },
      {
        "slug": "trdn",
        "symbol": "TRDN",
        "name": "triadin",
        "shared": 3,
        "url": "https://dantelabs.com/ro/genes/trdn"
      },
      {
        "slug": "casq2",
        "symbol": "CASQ2",
        "name": "calsequestrin 2",
        "shared": 2,
        "url": "https://dantelabs.com/ro/genes/casq2"
      },
      {
        "slug": "ryr2",
        "symbol": "RYR2",
        "name": "ryanodine receptor 2",
        "shared": 2,
        "url": "https://dantelabs.com/ro/genes/ryr2"
      },
      {
        "slug": "tecrl",
        "symbol": "TECRL",
        "name": "trans-2,3-enoyl-CoA reductase like",
        "shared": 2,
        "url": "https://dantelabs.com/ro/genes/tecrl"
      },
      {
        "slug": "cacna1c",
        "symbol": "CACNA1C",
        "name": "calcium voltage-gated channel subunit alpha1 C",
        "shared": 1,
        "url": "https://dantelabs.com/ro/genes/cacna1c"
      },
      {
        "slug": "kcne1",
        "symbol": "KCNE1",
        "name": "potassium voltage-gated channel subfamily E regulatory subunit 1",
        "shared": 1,
        "url": "https://dantelabs.com/ro/genes/kcne1"
      },
      {
        "slug": "kcnh2",
        "symbol": "KCNH2",
        "name": "potassium voltage-gated channel subfamily H member 2",
        "shared": 1,
        "url": "https://dantelabs.com/ro/genes/kcnh2"
      },
      {
        "slug": "kcnj2",
        "symbol": "KCNJ2",
        "name": "potassium inwardly rectifying channel subfamily J member 2",
        "shared": 1,
        "url": "https://dantelabs.com/ro/genes/kcnj2"
      },
      {
        "slug": "kcnq1",
        "symbol": "KCNQ1",
        "name": "potassium voltage-gated channel subfamily Q member 1",
        "shared": 1,
        "url": "https://dantelabs.com/ro/genes/kcnq1"
      },
      {
        "slug": "scn5a",
        "symbol": "SCN5A",
        "name": "sodium voltage-gated channel alpha subunit 5",
        "shared": 1,
        "url": "https://dantelabs.com/ro/genes/scn5a"
      }
    ],
    "sources": {
      "bundleId": "2026.10.16-c6eea6bf",
      "panel": "2026-10-16",
      "acmgSf": "SF v3.2"
    },
    "locusKind": "proteinCoding"
  },
  "variants": {
    "total": 0,
    "url": null,
    "items": []
  }
}