{
  "url": "https://dantelabs.com/traits/thyroid-carcinoma",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "thyroid-carcinoma",
    "id": "HP:0002890",
    "name": "Thyroid carcinoma",
    "definition": "The presence of a carcinoma of the thyroid gland.",
    "synonyms": [],
    "systems": [
      {
        "slug": "abnormality-of-the-endocrine-system",
        "name": "Abnormality of the endocrine system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-endocrine-system"
      },
      {
        "slug": "neoplasm",
        "name": "Abnormal tissue mass",
        "url": "https://dantelabs.com/traits/neoplasm"
      }
    ],
    "broader": [
      {
        "slug": "neoplasm-of-the-thyroid-gland",
        "name": "Neoplasm of the thyroid gland",
        "url": "https://dantelabs.com/traits/neoplasm-of-the-thyroid-gland"
      }
    ],
    "narrower": [
      {
        "slug": "papillary-thyroid-carcinoma",
        "name": "Papillary thyroid carcinoma",
        "genes": 24,
        "url": "https://dantelabs.com/traits/papillary-thyroid-carcinoma"
      },
      {
        "slug": "follicular-thyroid-carcinoma",
        "name": "Follicular thyroid carcinoma",
        "genes": 10,
        "url": "https://dantelabs.com/traits/follicular-thyroid-carcinoma"
      },
      {
        "slug": "non-medullary-thyroid-carcinoma",
        "name": "Non-medullary thyroid carcinoma",
        "genes": 6,
        "url": "https://dantelabs.com/traits/non-medullary-thyroid-carcinoma"
      },
      {
        "slug": "medullary-thyroid-carcinoma",
        "name": "Medullary thyroid carcinoma",
        "genes": 5,
        "url": "https://dantelabs.com/traits/medullary-thyroid-carcinoma"
      }
    ],
    "genes": [
      {
        "slug": "akt1",
        "symbol": "AKT1",
        "hgnc": "HGNC:391",
        "name": "AKT serine/threonine kinase 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/akt1"
      },
      {
        "slug": "cdkn1b",
        "symbol": "CDKN1B",
        "hgnc": "HGNC:1785",
        "name": "cyclin dependent kinase inhibitor 1B",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cdkn1b"
      },
      {
        "slug": "cdkn2b",
        "symbol": "CDKN2B",
        "hgnc": "HGNC:1788",
        "name": "cyclin dependent kinase inhibitor 2B",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cdkn2b"
      },
      {
        "slug": "foxi1",
        "symbol": "FOXI1",
        "hgnc": "HGNC:3815",
        "name": "forkhead box I1",
        "frequency": "occasional",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/foxi1"
      },
      {
        "slug": "kcnj10",
        "symbol": "KCNJ10",
        "hgnc": "HGNC:6256",
        "name": "potassium inwardly rectifying channel subfamily J member 10",
        "frequency": "occasional",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/kcnj10"
      },
      {
        "slug": "men1",
        "symbol": "MEN1",
        "hgnc": "HGNC:7010",
        "name": "menin 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/men1"
      },
      {
        "slug": "pten",
        "symbol": "PTEN",
        "hgnc": "HGNC:9588",
        "name": "phosphatase and tensin homolog",
        "frequency": "occasional",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/pten"
      },
      {
        "slug": "slc26a4",
        "symbol": "SLC26A4",
        "hgnc": "HGNC:8818",
        "name": "solute carrier family 26 member 4",
        "frequency": "occasional",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/slc26a4"
      },
      {
        "slug": "wrn",
        "symbol": "WRN",
        "hgnc": "HGNC:12791",
        "name": "WRN RecQ like helicase",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/wrn"
      },
      {
        "slug": "bmpr1a",
        "symbol": "BMPR1A",
        "hgnc": "HGNC:1076",
        "name": "bone morphogenetic protein receptor type 1A",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/bmpr1a"
      },
      {
        "slug": "casp10",
        "symbol": "CASP10",
        "hgnc": "HGNC:1500",
        "name": "caspase 10",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/casp10"
      },
      {
        "slug": "cdc73",
        "symbol": "CDC73",
        "hgnc": "HGNC:16783",
        "name": "cell division cycle 73",
        "frequency": "very-rare",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/cdc73"
      },
      {
        "slug": "cdkn2a",
        "symbol": "CDKN2A",
        "hgnc": "HGNC:1787",
        "name": "cyclin dependent kinase inhibitor 2A",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cdkn2a"
      },
      {
        "slug": "chek2",
        "symbol": "CHEK2",
        "hgnc": "HGNC:16627",
        "name": "checkpoint kinase 2",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/chek2"
      },
      {
        "slug": "dicer1",
        "symbol": "DICER1",
        "hgnc": "HGNC:17098",
        "name": "dicer 1, ribonuclease III",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dicer1"
      },
      {
        "slug": "fas",
        "symbol": "FAS",
        "hgnc": "HGNC:11920",
        "name": "Fas cell surface death receptor",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fas"
      },
      {
        "slug": "faslg",
        "symbol": "FASLG",
        "hgnc": "HGNC:11936",
        "name": "Fas ligand",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/faslg"
      },
      {
        "slug": "grem1",
        "symbol": "GREM1",
        "hgnc": "HGNC:2001",
        "name": "gremlin 1, DAN family BMP antagonist",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/grem1"
      },
      {
        "slug": "hepacam",
        "symbol": "HEPACAM",
        "hgnc": "HGNC:26361",
        "name": "hepatic and glial cell adhesion molecule",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hepacam"
      },
      {
        "slug": "keap1",
        "symbol": "KEAP1",
        "hgnc": "HGNC:23177",
        "name": "kelch like ECH associated protein 1",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/keap1"
      },
      {
        "slug": "mdm2",
        "symbol": "MDM2",
        "hgnc": "HGNC:6973",
        "name": "MDM2 proto-oncogene",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mdm2"
      },
      {
        "slug": "pde11a",
        "symbol": "PDE11A",
        "hgnc": "HGNC:8773",
        "name": "phosphodiesterase 11A",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pde11a"
      },
      {
        "slug": "prkar1a",
        "symbol": "PRKAR1A",
        "hgnc": "HGNC:9388",
        "name": "protein kinase cAMP-dependent type I regulatory subunit alpha",
        "frequency": "very-rare",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/prkar1a"
      },
      {
        "slug": "tp53",
        "symbol": "TP53",
        "hgnc": "HGNC:11998",
        "name": "tumor protein p53",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tp53"
      },
      {
        "slug": "tg",
        "symbol": "TG",
        "hgnc": "HGNC:11764",
        "name": "thyroglobulin",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tg"
      }
    ]
  }
}