{
  "url": "https://dantelabs.com/traits/spinal-rigidity",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "spinal-rigidity",
    "id": "HP:0003306",
    "name": "Reduced spine movement",
    "label": "Spinal rigidity",
    "definition": "Reduced ability to move the vertebral column with a resulting limitation of neck and trunk flexion.",
    "synonyms": [
      "Rigid spine"
    ],
    "systems": [
      {
        "slug": "abnormality-of-the-musculoskeletal-system",
        "name": "Abnormality of the musculoskeletal system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-musculoskeletal-system"
      }
    ],
    "broader": [
      {
        "slug": "abnormality-of-the-vertebral-column",
        "name": "Abnormality of the vertebral column",
        "url": "https://dantelabs.com/traits/abnormality-of-the-vertebral-column"
      }
    ],
    "narrower": [],
    "genes": [
      {
        "slug": "col6a1",
        "symbol": "COL6A1",
        "hgnc": "HGNC:2211",
        "name": "collagen type VI alpha 1 chain",
        "frequency": "obligate",
        "diseases": 3,
        "url": "https://dantelabs.com/genes/col6a1"
      },
      {
        "slug": "fhl1",
        "symbol": "FHL1",
        "hgnc": "HGNC:3702",
        "name": "four and a half LIM domains 1",
        "frequency": "obligate",
        "diseases": 4,
        "url": "https://dantelabs.com/genes/fhl1"
      },
      {
        "slug": "filip1",
        "symbol": "FILIP1",
        "hgnc": "HGNC:21015",
        "name": "filamin A interacting protein 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/filip1"
      },
      {
        "slug": "hmgcs1",
        "symbol": "HMGCS1",
        "hgnc": "HGNC:5007",
        "name": "3-hydroxy-3-methylglutaryl-CoA synthase 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hmgcs1"
      },
      {
        "slug": "hspb8",
        "symbol": "HSPB8",
        "hgnc": "HGNC:30171",
        "name": "heat shock protein family B (small) member 8",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hspb8"
      },
      {
        "slug": "ky",
        "symbol": "KY",
        "hgnc": "HGNC:26576",
        "name": "kyphoscoliosis peptidase",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ky"
      },
      {
        "slug": "lmna",
        "symbol": "LMNA",
        "hgnc": "HGNC:6636",
        "name": "lamin A/C",
        "frequency": "obligate",
        "diseases": 5,
        "url": "https://dantelabs.com/genes/lmna"
      },
      {
        "slug": "mymk",
        "symbol": "MYMK",
        "hgnc": "HGNC:33778",
        "name": "myomaker, myoblast fusion factor",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mymk"
      },
      {
        "slug": "orai1",
        "symbol": "ORAI1",
        "hgnc": "HGNC:25896",
        "name": "ORAI calcium release-activated calcium modulator 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/orai1"
      },
      {
        "slug": "tnnt1",
        "symbol": "TNNT1",
        "hgnc": "HGNC:11948",
        "name": "troponin T1, slow skeletal type",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tnnt1"
      },
      {
        "slug": "trim63",
        "symbol": "TRIM63",
        "hgnc": "HGNC:16007",
        "name": "tripartite motif containing 63",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/trim63"
      },
      {
        "slug": "acta1",
        "symbol": "ACTA1",
        "hgnc": "HGNC:129",
        "name": "actin alpha 1, skeletal muscle",
        "frequency": "very-frequent",
        "diseases": 4,
        "url": "https://dantelabs.com/genes/acta1"
      },
      {
        "slug": "acvr1",
        "symbol": "ACVR1",
        "hgnc": "HGNC:171",
        "name": "activin A receptor type 1",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/acvr1"
      },
      {
        "slug": "col12a1",
        "symbol": "COL12A1",
        "hgnc": "HGNC:2188",
        "name": "collagen type XII alpha 1 chain",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/col12a1"
      },
      {
        "slug": "col6a2",
        "symbol": "COL6A2",
        "hgnc": "HGNC:2212",
        "name": "collagen type VI alpha 2 chain",
        "frequency": "very-frequent",
        "diseases": 5,
        "url": "https://dantelabs.com/genes/col6a2"
      },
      {
        "slug": "col6a3",
        "symbol": "COL6A3",
        "hgnc": "HGNC:2213",
        "name": "collagen type VI alpha 3 chain",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/col6a3"
      },
      {
        "slug": "selenon",
        "symbol": "SELENON",
        "hgnc": "HGNC:15999",
        "name": "selenoprotein N",
        "frequency": "very-frequent",
        "diseases": 3,
        "url": "https://dantelabs.com/genes/selenon"
      },
      {
        "slug": "adamts15",
        "symbol": "ADAMTS15",
        "hgnc": "HGNC:16305",
        "name": "ADAM metallopeptidase with thrombospondin type 1 motif 15",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/adamts15"
      },
      {
        "slug": "bag3",
        "symbol": "BAG3",
        "hgnc": "HGNC:939",
        "name": "BAG cochaperone 3",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/bag3"
      },
      {
        "slug": "capn3",
        "symbol": "CAPN3",
        "hgnc": "HGNC:1480",
        "name": "calpain 3",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/capn3"
      },
      {
        "slug": "col13a1",
        "symbol": "COL13A1",
        "hgnc": "HGNC:2190",
        "name": "collagen type XIII alpha 1 chain",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/col13a1"
      },
      {
        "slug": "dnajb4",
        "symbol": "DNAJB4",
        "hgnc": "HGNC:14886",
        "name": "DnaJ heat shock protein family (Hsp40) member B4",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dnajb4"
      },
      {
        "slug": "emd",
        "symbol": "EMD",
        "hgnc": "HGNC:3331",
        "name": "emerin",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/emd"
      },
      {
        "slug": "hspg2",
        "symbol": "HSPG2",
        "hgnc": "HGNC:5273",
        "name": "heparan sulfate proteoglycan 2",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hspg2"
      },
      {
        "slug": "jag2",
        "symbol": "JAG2",
        "hgnc": "HGNC:6189",
        "name": "jagged canonical Notch ligand 2",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/jag2"
      },
      {
        "slug": "kbtbd13",
        "symbol": "KBTBD13",
        "hgnc": "HGNC:37227",
        "name": "kelch repeat and BTB domain containing 13",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/kbtbd13"
      },
      {
        "slug": "klhl41",
        "symbol": "KLHL41",
        "hgnc": "HGNC:16905",
        "name": "kelch like family member 41",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/klhl41"
      },
      {
        "slug": "mgme1",
        "symbol": "MGME1",
        "hgnc": "HGNC:16205",
        "name": "mitochondrial genome maintenance exonuclease 1",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/mgme1"
      },
      {
        "slug": "mybpc1",
        "symbol": "MYBPC1",
        "hgnc": "HGNC:7549",
        "name": "myosin binding protein C1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mybpc1"
      },
      {
        "slug": "myh7",
        "symbol": "MYH7",
        "hgnc": "HGNC:7577",
        "name": "myosin heavy chain 7",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/myh7"
      },
      {
        "slug": "mypn",
        "symbol": "MYPN",
        "hgnc": "HGNC:23246",
        "name": "myopalladin",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mypn"
      },
      {
        "slug": "neb",
        "symbol": "NEB",
        "hgnc": "HGNC:7720",
        "name": "nebulin",
        "frequency": "frequent",
        "diseases": 3,
        "url": "https://dantelabs.com/genes/neb"
      },
      {
        "slug": "syne1",
        "symbol": "SYNE1",
        "hgnc": "HGNC:17089",
        "name": "spectrin repeat containing nuclear envelope protein 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/syne1"
      },
      {
        "slug": "syne2",
        "symbol": "SYNE2",
        "hgnc": "HGNC:17084",
        "name": "spectrin repeat containing nuclear envelope protein 2",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/syne2"
      },
      {
        "slug": "tmem43",
        "symbol": "TMEM43",
        "hgnc": "HGNC:28472",
        "name": "transmembrane protein 43",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tmem43"
      },
      {
        "slug": "tor1aip1",
        "symbol": "TOR1AIP1",
        "hgnc": "HGNC:29456",
        "name": "torsin 1A interacting protein 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tor1aip1"
      },
      {
        "slug": "tpm2",
        "symbol": "TPM2",
        "hgnc": "HGNC:12011",
        "name": "tropomyosin 2",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/tpm2"
      },
      {
        "slug": "tpm3",
        "symbol": "TPM3",
        "hgnc": "HGNC:12012",
        "name": "tropomyosin 3",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tpm3"
      },
      {
        "slug": "trip4",
        "symbol": "TRIP4",
        "hgnc": "HGNC:12310",
        "name": "thyroid hormone receptor interactor 4",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/trip4"
      },
      {
        "slug": "ttn",
        "symbol": "TTN",
        "hgnc": "HGNC:12403",
        "name": "titin",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ttn"
      },
      {
        "slug": "cfl2",
        "symbol": "CFL2",
        "hgnc": "HGNC:1875",
        "name": "cofilin 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cfl2"
      },
      {
        "slug": "col2a1",
        "symbol": "COL2A1",
        "hgnc": "HGNC:2200",
        "name": "collagen type II alpha 1 chain",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/col2a1"
      },
      {
        "slug": "erlin2",
        "symbol": "ERLIN2",
        "hgnc": "HGNC:1356",
        "name": "ER lipid raft associated 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/erlin2"
      },
      {
        "slug": "inpp5k",
        "symbol": "INPP5K",
        "hgnc": "HGNC:33882",
        "name": "inositol polyphosphate-5-phosphatase K",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/inpp5k"
      },
      {
        "slug": "jph1",
        "symbol": "JPH1",
        "hgnc": "HGNC:14201",
        "name": "junctophilin 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/jph1"
      },
      {
        "slug": "lmod3",
        "symbol": "LMOD3",
        "hgnc": "HGNC:6649",
        "name": "leiomodin 3",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lmod3"
      },
      {
        "slug": "pomt1",
        "symbol": "POMT1",
        "hgnc": "HGNC:9202",
        "name": "protein O-mannosyltransferase 1",
        "frequency": "occasional",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/pomt1"
      },
      {
        "slug": "pyroxd1",
        "symbol": "PYROXD1",
        "hgnc": "HGNC:26162",
        "name": "pyridine nucleotide-disulphide oxidoreductase domain 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pyroxd1"
      },
      {
        "slug": "scn4a",
        "symbol": "SCN4A",
        "hgnc": "HGNC:10591",
        "name": "sodium voltage-gated channel alpha subunit 4",
        "frequency": "occasional",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/scn4a"
      },
      {
        "slug": "snupn",
        "symbol": "SNUPN",
        "hgnc": "HGNC:14245",
        "name": "snurportin 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/snupn"
      },
      {
        "slug": "tnpo3",
        "symbol": "TNPO3",
        "hgnc": "HGNC:17103",
        "name": "transportin 3",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tnpo3"
      },
      {
        "slug": "des",
        "symbol": "DES",
        "hgnc": "HGNC:2770",
        "name": "desmin",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/des"
      },
      {
        "slug": "dysf",
        "symbol": "DYSF",
        "hgnc": "HGNC:3097",
        "name": "dysferlin",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dysf"
      },
      {
        "slug": "cavin1",
        "symbol": "CAVIN1",
        "hgnc": "HGNC:9688",
        "name": "caveolae associated protein 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cavin1"
      },
      {
        "slug": "fktn",
        "symbol": "FKTN",
        "hgnc": "HGNC:3622",
        "name": "fukutin",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fktn"
      },
      {
        "slug": "pomt2",
        "symbol": "POMT2",
        "hgnc": "HGNC:19743",
        "name": "protein O-mannosyltransferase 2",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pomt2"
      },
      {
        "slug": "vamp1",
        "symbol": "VAMP1",
        "hgnc": "HGNC:12642",
        "name": "vesicle associated membrane protein 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/vamp1"
      }
    ]
  }
}