{
  "url": "https://dantelabs.com/traits/multinodular-goiter",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "multinodular-goiter",
    "id": "HP:0005987",
    "name": "Multinodular goiter",
    "definition": "Enlargement of the thyroid gland related to multiple nodules in the thyroid gland.",
    "synonyms": [
      "Multinodular goitre"
    ],
    "systems": [
      {
        "slug": "abnormality-of-the-endocrine-system",
        "name": "Abnormality of the endocrine system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-endocrine-system"
      }
    ],
    "broader": [
      {
        "slug": "nodular-goiter",
        "name": "Nodular goiter",
        "url": "https://dantelabs.com/traits/nodular-goiter"
      }
    ],
    "narrower": [],
    "genes": [
      {
        "slug": "dicer1",
        "symbol": "DICER1",
        "hgnc": "HGNC:17098",
        "name": "dicer 1, ribonuclease III",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/dicer1"
      },
      {
        "slug": "keap1",
        "symbol": "KEAP1",
        "hgnc": "HGNC:23177",
        "name": "kelch like ECH associated protein 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/keap1"
      },
      {
        "slug": "mad1l1",
        "symbol": "MAD1L1",
        "hgnc": "HGNC:6762",
        "name": "mitotic arrest deficient 1 like 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mad1l1"
      },
      {
        "slug": "tg",
        "symbol": "TG",
        "hgnc": "HGNC:11764",
        "name": "thyroglobulin",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tg"
      },
      {
        "slug": "aip",
        "symbol": "AIP",
        "hgnc": "HGNC:358",
        "name": "AHR interacting HSP90 co-chaperone",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/aip"
      },
      {
        "slug": "gpr101",
        "symbol": "GPR101",
        "hgnc": "HGNC:14963",
        "name": "G protein-coupled receptor 101",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gpr101"
      },
      {
        "slug": "sash1",
        "symbol": "SASH1",
        "hgnc": "HGNC:19182",
        "name": "SAM and SH3 domain containing 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sash1"
      },
      {
        "slug": "alms1",
        "symbol": "ALMS1",
        "hgnc": "HGNC:428",
        "name": "ALMS1 centrosome and basal body associated protein",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/alms1"
      },
      {
        "slug": "nkx2-1",
        "symbol": "NKX2-1",
        "hgnc": "HGNC:11825",
        "name": "NK2 homeobox 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nkx2-1"
      }
    ]
  }
}