{
  "url": "https://dantelabs.com/traits/liver-abscess",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "liver-abscess",
    "id": "HP:0100523",
    "name": "Liver abscess",
    "definition": "A localized, circumscribed collection of purulent material (pus) within the liver parenchyma, typically resulting from a bacterial, parasitic, or fungal infection. Unlike hepatitis, which is often diffuse, an abscess is a focal lesion.",
    "synonyms": [
      "Hepatic abscess",
      "Purulent hepatic collection"
    ],
    "systems": [
      {
        "slug": "abnormality-of-the-digestive-system",
        "name": "Abnormality of the digestive system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-digestive-system"
      },
      {
        "slug": "abnormality-of-the-immune-system",
        "name": "Abnormality of the immune system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-immune-system"
      }
    ],
    "broader": [
      {
        "slug": "abnormal-liver-morphology",
        "name": "Abnormal liver morphology",
        "url": "https://dantelabs.com/traits/abnormal-liver-morphology"
      },
      {
        "slug": "abscess",
        "name": "Abscess",
        "url": "https://dantelabs.com/traits/abscess"
      }
    ],
    "narrower": [],
    "genes": [
      {
        "slug": "irak4",
        "symbol": "IRAK4",
        "hgnc": "HGNC:17967",
        "name": "interleukin 1 receptor associated kinase 4",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/irak4"
      },
      {
        "slug": "ctsc",
        "symbol": "CTSC",
        "hgnc": "HGNC:2528",
        "name": "cathepsin C",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ctsc"
      },
      {
        "slug": "cyba",
        "symbol": "CYBA",
        "hgnc": "HGNC:2577",
        "name": "cytochrome b-245 alpha chain",
        "frequency": "occasional",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/cyba"
      },
      {
        "slug": "cybb",
        "symbol": "CYBB",
        "hgnc": "HGNC:2578",
        "name": "cytochrome b-245 beta chain",
        "frequency": "occasional",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/cybb"
      },
      {
        "slug": "cybc1",
        "symbol": "CYBC1",
        "hgnc": "HGNC:28672",
        "name": "cytochrome b-245 chaperone 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cybc1"
      },
      {
        "slug": "ncf1",
        "symbol": "NCF1",
        "hgnc": "HGNC:7660",
        "name": "neutrophil cytosolic factor 1",
        "frequency": "occasional",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/ncf1"
      },
      {
        "slug": "ncf2",
        "symbol": "NCF2",
        "hgnc": "HGNC:7661",
        "name": "neutrophil cytosolic factor 2",
        "frequency": "occasional",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/ncf2"
      },
      {
        "slug": "ncf4",
        "symbol": "NCF4",
        "hgnc": "HGNC:7662",
        "name": "neutrophil cytosolic factor 4",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ncf4"
      },
      {
        "slug": "abcb4",
        "symbol": "ABCB4",
        "hgnc": "HGNC:45",
        "name": "ATP binding cassette subfamily B member 4",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/abcb4"
      },
      {
        "slug": "ighg2",
        "symbol": "IGHG2",
        "hgnc": "HGNC:5526",
        "name": "immunoglobulin heavy constant gamma 2 (G2m marker)",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ighg2"
      },
      {
        "slug": "igkc",
        "symbol": "IGKC",
        "hgnc": "HGNC:5716",
        "name": "immunoglobulin kappa constant",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/igkc"
      },
      {
        "slug": "pkhd1",
        "symbol": "PKHD1",
        "hgnc": "HGNC:9016",
        "name": "PKHD1 ciliary IPT domain containing fibrocystin/polyductin",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pkhd1"
      }
    ]
  }
}