{
  "url": "https://dantelabs.com/traits/left-ventricular-noncompaction",
  "trait": {
    "bundleId": "2026.10.16-c6eea6bf",
    "release": "2026-09-01",
    "slug": "left-ventricular-noncompaction",
    "id": "HP:0030682",
    "name": "Left ventricular noncompaction",
    "definition": "Left ventricular noncompaction (LVNC) is defined by 3 markers: prominent left ventricular (LV) trabeculae, deep intertrabecular recesses, and the thin compacted layer.",
    "synonyms": [],
    "systems": [
      {
        "slug": "abnormality-of-the-cardiovascular-system",
        "name": "Abnormality of the cardiovascular system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-cardiovascular-system"
      }
    ],
    "broader": [
      {
        "slug": "abnormal-morphology-of-left-ventricular-trabeculae",
        "name": "Abnormal morphology of left ventricular trabeculae",
        "url": "https://dantelabs.com/traits/abnormal-morphology-of-left-ventricular-trabeculae"
      }
    ],
    "narrower": [],
    "genes": [
      {
        "slug": "coa6",
        "symbol": "COA6",
        "hgnc": "HGNC:18025",
        "name": "cytochrome c oxidase assembly factor 6",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/coa6"
      },
      {
        "slug": "dtna",
        "symbol": "DTNA",
        "hgnc": "HGNC:3057",
        "name": "dystrobrevin alpha",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dtna"
      },
      {
        "slug": "ldb3",
        "symbol": "LDB3",
        "hgnc": "HGNC:15710",
        "name": "LIM domain binding 3",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/ldb3"
      },
      {
        "slug": "mipep",
        "symbol": "MIPEP",
        "hgnc": "HGNC:7104",
        "name": "mitochondrial intermediate peptidase",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mipep"
      },
      {
        "slug": "mybpc3",
        "symbol": "MYBPC3",
        "hgnc": "HGNC:7551",
        "name": "myosin binding protein C3",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mybpc3"
      },
      {
        "slug": "nrap",
        "symbol": "NRAP",
        "hgnc": "HGNC:7988",
        "name": "nebulin related anchoring protein",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nrap"
      },
      {
        "slug": "prdm16",
        "symbol": "PRDM16",
        "hgnc": "HGNC:14000",
        "name": "PR/SET domain 16",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/prdm16"
      },
      {
        "slug": "sdhd",
        "symbol": "SDHD",
        "hgnc": "HGNC:10683",
        "name": "succinate dehydrogenase complex subunit D",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sdhd"
      },
      {
        "slug": "tnnt2",
        "symbol": "TNNT2",
        "hgnc": "HGNC:11949",
        "name": "troponin T2, cardiac type",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tnnt2"
      },
      {
        "slug": "vars2",
        "symbol": "VARS2",
        "hgnc": "HGNC:21642",
        "name": "valyl-tRNA synthetase 2, mitochondrial",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/vars2"
      },
      {
        "slug": "myh7",
        "symbol": "MYH7",
        "hgnc": "HGNC:7577",
        "name": "myosin heavy chain 7",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/myh7"
      },
      {
        "slug": "hcn4",
        "symbol": "HCN4",
        "hgnc": "HGNC:16882",
        "name": "hyperpolarization activated cyclic nucleotide gated potassium channel 4",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hcn4"
      },
      {
        "slug": "nppa",
        "symbol": "NPPA",
        "hgnc": "HGNC:7939",
        "name": "natriuretic peptide A",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nppa"
      },
      {
        "slug": "scn5a",
        "symbol": "SCN5A",
        "hgnc": "HGNC:10593",
        "name": "sodium voltage-gated channel alpha subunit 5",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/scn5a"
      },
      {
        "slug": "sdha",
        "symbol": "SDHA",
        "hgnc": "HGNC:10680",
        "name": "succinate dehydrogenase complex flavoprotein subunit A",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/sdha"
      },
      {
        "slug": "actc1",
        "symbol": "ACTC1",
        "hgnc": "HGNC:143",
        "name": "actin alpha cardiac muscle 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/actc1"
      },
      {
        "slug": "actn2",
        "symbol": "ACTN2",
        "hgnc": "HGNC:164",
        "name": "actinin alpha 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/actn2"
      },
      {
        "slug": "calm2",
        "symbol": "CALM2",
        "hgnc": "HGNC:1445",
        "name": "calmodulin 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/calm2"
      },
      {
        "slug": "mib1",
        "symbol": "MIB1",
        "hgnc": "HGNC:21086",
        "name": "MIB E3 ubiquitin protein ligase 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mib1"
      },
      {
        "slug": "nono",
        "symbol": "NONO",
        "hgnc": "HGNC:7871",
        "name": "non-POU domain containing octamer binding",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nono"
      }
    ]
  }
}