{
  "url": "https://dantelabs.com/traits/hypoplastic-optic-chiasm",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "hypoplastic-optic-chiasm",
    "id": "HP:0034311",
    "name": "Hypoplastic optic chiasm",
    "definition": "Developmental defect characterized by undergrowth of the optic chiasm.",
    "synonyms": [
      "Optic chiasm hypoplasia"
    ],
    "systems": [
      {
        "slug": "abnormality-of-the-eye",
        "name": "Abnormality of the eye",
        "url": "https://dantelabs.com/traits/abnormality-of-the-eye"
      }
    ],
    "broader": [
      {
        "slug": "abnormal-optic-chiasm-morphology",
        "name": "Abnormal optic chiasm morphology",
        "url": "https://dantelabs.com/traits/abnormal-optic-chiasm-morphology"
      }
    ],
    "narrower": [],
    "genes": [
      {
        "slug": "otx2",
        "symbol": "OTX2",
        "hgnc": "HGNC:8522",
        "name": "orthodenticle homeobox 2",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/otx2"
      },
      {
        "slug": "rbsn",
        "symbol": "RBSN",
        "hgnc": "HGNC:20759",
        "name": "rabenosyn, RAB effector",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rbsn"
      },
      {
        "slug": "tbc1d32",
        "symbol": "TBC1D32",
        "hgnc": "HGNC:21485",
        "name": "TBC1 domain family member 32",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tbc1d32"
      },
      {
        "slug": "aldh1a3",
        "symbol": "ALDH1A3",
        "hgnc": "HGNC:409",
        "name": "aldehyde dehydrogenase 1 family member A3",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/aldh1a3"
      },
      {
        "slug": "trappc12",
        "symbol": "TRAPPC12",
        "hgnc": "HGNC:24284",
        "name": "trafficking protein particle complex subunit 12",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/trappc12"
      },
      {
        "slug": "diaph1",
        "symbol": "DIAPH1",
        "hgnc": "HGNC:2876",
        "name": "diaphanous related formin 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/diaph1"
      },
      {
        "slug": "opa1",
        "symbol": "OPA1",
        "hgnc": "HGNC:8140",
        "name": "OPA1 mitochondrial dynamin like GTPase",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/opa1"
      }
    ]
  }
}