{
  "url": "https://dantelabs.com/traits/hematuria",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "hematuria",
    "id": "HP:0000790",
    "name": "Blood in urine",
    "label": "Hematuria",
    "definition": "The presence of blood in the urine. Hematuria may be gross hematuria (visible to the naked eye) or microscopic hematuria (detected by dipstick or microscopic examination of the urine).",
    "synonyms": [
      "High urine occult blood"
    ],
    "systems": [
      {
        "slug": "abnormality-of-metabolism-homeostasis",
        "name": "Laboratory abnormality",
        "url": "https://dantelabs.com/traits/abnormality-of-metabolism-homeostasis"
      },
      {
        "slug": "abnormality-of-the-genitourinary-system",
        "name": "Abnormality of the genitourinary system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-genitourinary-system"
      }
    ],
    "broader": [
      {
        "slug": "abnormal-renal-physiology",
        "name": "Abnormal kidney function",
        "url": "https://dantelabs.com/traits/abnormal-renal-physiology"
      },
      {
        "slug": "abnormal-urine-cytology",
        "name": "Abnormal urine cytology",
        "url": "https://dantelabs.com/traits/abnormal-urine-cytology"
      }
    ],
    "narrower": [
      {
        "slug": "microscopic-hematuria",
        "name": "Small amount of blood in urine",
        "genes": 37,
        "url": "https://dantelabs.com/traits/microscopic-hematuria"
      },
      {
        "slug": "macroscopic-hematuria",
        "name": "Bloody urine",
        "genes": 24,
        "url": "https://dantelabs.com/traits/macroscopic-hematuria"
      }
    ],
    "genes": [
      {
        "slug": "aprt",
        "symbol": "APRT",
        "hgnc": "HGNC:626",
        "name": "adenine phosphoribosyltransferase",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/aprt"
      },
      {
        "slug": "ctns",
        "symbol": "CTNS",
        "hgnc": "HGNC:2518",
        "name": "cystinosin, lysosomal cystine transporter",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ctns"
      },
      {
        "slug": "hmox1",
        "symbol": "HMOX1",
        "hgnc": "HGNC:5013",
        "name": "heme oxygenase 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hmox1"
      },
      {
        "slug": "ift140",
        "symbol": "IFT140",
        "hgnc": "HGNC:29077",
        "name": "intraflagellar transport 140",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/ift140"
      },
      {
        "slug": "lamb2",
        "symbol": "LAMB2",
        "hgnc": "HGNC:6487",
        "name": "laminin subunit beta 2",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lamb2"
      },
      {
        "slug": "lars2",
        "symbol": "LARS2",
        "hgnc": "HGNC:17095",
        "name": "leucyl-tRNA synthetase 2, mitochondrial",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lars2"
      },
      {
        "slug": "mccc1",
        "symbol": "MCCC1",
        "hgnc": "HGNC:6936",
        "name": "methylcrotonyl-CoA carboxylase subunit 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mccc1"
      },
      {
        "slug": "myo1e",
        "symbol": "MYO1E",
        "hgnc": "HGNC:7599",
        "name": "myosin IE",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/myo1e"
      },
      {
        "slug": "pld4",
        "symbol": "PLD4",
        "hgnc": "HGNC:23792",
        "name": "phospholipase D family member 4",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pld4"
      },
      {
        "slug": "col4a3",
        "symbol": "COL4A3",
        "hgnc": "HGNC:2204",
        "name": "collagen type IV alpha 3 chain",
        "frequency": "very-frequent",
        "diseases": 3,
        "url": "https://dantelabs.com/genes/col4a3"
      },
      {
        "slug": "col4a4",
        "symbol": "COL4A4",
        "hgnc": "HGNC:2206",
        "name": "collagen type IV alpha 4 chain",
        "frequency": "very-frequent",
        "diseases": 4,
        "url": "https://dantelabs.com/genes/col4a4"
      },
      {
        "slug": "ctla4",
        "symbol": "CTLA4",
        "hgnc": "HGNC:2505",
        "name": "cytotoxic T-lymphocyte associated protein 4",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/ctla4"
      },
      {
        "slug": "gla",
        "symbol": "GLA",
        "hgnc": "HGNC:4296",
        "name": "galactosidase alpha",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gla"
      },
      {
        "slug": "hla-dpa1",
        "symbol": "HLA-DPA1",
        "hgnc": "HGNC:4938",
        "name": "major histocompatibility complex, class II, DP alpha 1",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hla-dpa1"
      },
      {
        "slug": "hla-dpb1",
        "symbol": "HLA-DPB1",
        "hgnc": "HGNC:4940",
        "name": "major histocompatibility complex, class II, DP beta 1",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hla-dpb1"
      },
      {
        "slug": "hoga1",
        "symbol": "HOGA1",
        "hgnc": "HGNC:25155",
        "name": "4-hydroxy-2-oxoglutarate aldolase 1",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hoga1"
      },
      {
        "slug": "prtn3",
        "symbol": "PRTN3",
        "hgnc": "HGNC:9495",
        "name": "proteinase 3",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/prtn3"
      },
      {
        "slug": "ptpn22",
        "symbol": "PTPN22",
        "hgnc": "HGNC:9652",
        "name": "protein tyrosine phosphatase non-receptor type 22",
        "frequency": "very-frequent",
        "diseases": 3,
        "url": "https://dantelabs.com/genes/ptpn22"
      },
      {
        "slug": "agxt",
        "symbol": "AGXT",
        "hgnc": "HGNC:341",
        "name": "alanine--glyoxylate aminotransferase",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/agxt"
      },
      {
        "slug": "alg5",
        "symbol": "ALG5",
        "hgnc": "HGNC:20266",
        "name": "ALG5 dolichyl-phosphate beta-glucosyltransferase",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/alg5"
      },
      {
        "slug": "alg9",
        "symbol": "ALG9",
        "hgnc": "HGNC:15672",
        "name": "ALG9 alpha-1,2-mannosyltransferase",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/alg9"
      },
      {
        "slug": "bank1",
        "symbol": "BANK1",
        "hgnc": "HGNC:18233",
        "name": "B cell scaffold protein with ankyrin repeats 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/bank1"
      },
      {
        "slug": "bicc1",
        "symbol": "BICC1",
        "hgnc": "HGNC:19351",
        "name": "BicC family RNA binding protein 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/bicc1"
      },
      {
        "slug": "blk",
        "symbol": "BLK",
        "hgnc": "HGNC:1057",
        "name": "BLK proto-oncogene, Src family tyrosine kinase",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/blk"
      },
      {
        "slug": "c4a",
        "symbol": "C4A",
        "hgnc": "HGNC:1323",
        "name": "complement C4A (Chido/Rodgers blood group)",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/c4a"
      },
      {
        "slug": "c4b",
        "symbol": "C4B",
        "hgnc": "HGNC:1324",
        "name": "complement C4B (Chido/Rodgers blood group)",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/c4b"
      },
      {
        "slug": "cldn19",
        "symbol": "CLDN19",
        "hgnc": "HGNC:2040",
        "name": "claudin 19",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cldn19"
      },
      {
        "slug": "col4a1",
        "symbol": "COL4A1",
        "hgnc": "HGNC:2202",
        "name": "collagen type IV alpha 1 chain",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/col4a1"
      },
      {
        "slug": "col4a5",
        "symbol": "COL4A5",
        "hgnc": "HGNC:2207",
        "name": "collagen type IV alpha 5 chain",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/col4a5"
      },
      {
        "slug": "col4a6",
        "symbol": "COL4A6",
        "hgnc": "HGNC:2208",
        "name": "collagen type IV alpha 6 chain",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/col4a6"
      },
      {
        "slug": "cr2",
        "symbol": "CR2",
        "hgnc": "HGNC:2336",
        "name": "complement C3d receptor 2",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cr2"
      },
      {
        "slug": "dgke",
        "symbol": "DGKE",
        "hgnc": "HGNC:2852",
        "name": "diacylglycerol kinase epsilon",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dgke"
      },
      {
        "slug": "dnajb11",
        "symbol": "DNAJB11",
        "hgnc": "HGNC:14889",
        "name": "DnaJ heat shock protein family (Hsp40) member B11",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dnajb11"
      },
      {
        "slug": "dnase1",
        "symbol": "DNASE1",
        "hgnc": "HGNC:2956",
        "name": "deoxyribonuclease 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dnase1"
      },
      {
        "slug": "dnase1l3",
        "symbol": "DNASE1L3",
        "hgnc": "HGNC:2959",
        "name": "deoxyribonuclease 1L3",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dnase1l3"
      },
      {
        "slug": "ets1",
        "symbol": "ETS1",
        "hgnc": "HGNC:3488",
        "name": "ETS proto-oncogene 1, transcription factor",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ets1"
      },
      {
        "slug": "fcgr2b",
        "symbol": "FCGR2B",
        "hgnc": "HGNC:3618",
        "name": "Fc gamma receptor IIb",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fcgr2b"
      },
      {
        "slug": "fcgr3b",
        "symbol": "FCGR3B",
        "hgnc": "HGNC:3620",
        "name": "Fc gamma receptor IIIb",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fcgr3b"
      },
      {
        "slug": "ganab",
        "symbol": "GANAB",
        "hgnc": "HGNC:4138",
        "name": "glucosidase II alpha subunit",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ganab"
      },
      {
        "slug": "hla-drb1",
        "symbol": "HLA-DRB1",
        "hgnc": "HGNC:4948",
        "name": "major histocompatibility complex, class II, DR beta 1",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/hla-drb1"
      },
      {
        "slug": "hnf1b",
        "symbol": "HNF1B",
        "hgnc": "HGNC:11630",
        "name": "HNF1 homeobox B",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hnf1b"
      },
      {
        "slug": "hprt1",
        "symbol": "HPRT1",
        "hgnc": "HGNC:5157",
        "name": "hypoxanthine phosphoribosyltransferase 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hprt1"
      },
      {
        "slug": "ighg1",
        "symbol": "IGHG1",
        "hgnc": "HGNC:5525",
        "name": "immunoglobulin heavy constant gamma 1 (G1m marker)",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ighg1"
      },
      {
        "slug": "il10",
        "symbol": "IL10",
        "hgnc": "HGNC:5962",
        "name": "interleukin 10",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/il10"
      },
      {
        "slug": "irak1",
        "symbol": "IRAK1",
        "hgnc": "HGNC:6112",
        "name": "interleukin 1 receptor associated kinase 1",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/irak1"
      },
      {
        "slug": "irf5",
        "symbol": "IRF5",
        "hgnc": "HGNC:6120",
        "name": "interferon regulatory factor 5",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/irf5"
      },
      {
        "slug": "itga6",
        "symbol": "ITGA6",
        "hgnc": "HGNC:6142",
        "name": "integrin subunit alpha 6",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/itga6"
      },
      {
        "slug": "itgam",
        "symbol": "ITGAM",
        "hgnc": "HGNC:6149",
        "name": "integrin subunit alpha M",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/itgam"
      },
      {
        "slug": "itgb4",
        "symbol": "ITGB4",
        "hgnc": "HGNC:6158",
        "name": "integrin subunit beta 4",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/itgb4"
      },
      {
        "slug": "jazf1",
        "symbol": "JAZF1",
        "hgnc": "HGNC:28917",
        "name": "JAZF zinc finger 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/jazf1"
      },
      {
        "slug": "kank2",
        "symbol": "KANK2",
        "hgnc": "HGNC:29300",
        "name": "KN motif and ankyrin repeat domains 2",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/kank2"
      },
      {
        "slug": "kiaa0319l",
        "symbol": "KIAA0319L",
        "hgnc": "HGNC:30071",
        "name": "KIAA0319 like",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/kiaa0319l"
      },
      {
        "slug": "mecp2",
        "symbol": "MECP2",
        "hgnc": "HGNC:6990",
        "name": "methyl-CpG binding protein 2",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mecp2"
      },
      {
        "slug": "nek8",
        "symbol": "NEK8",
        "hgnc": "HGNC:13387",
        "name": "NIMA related kinase 8",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nek8"
      },
      {
        "slug": "pax2",
        "symbol": "PAX2",
        "hgnc": "HGNC:8616",
        "name": "paired box 2",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pax2"
      },
      {
        "slug": "pdcd1",
        "symbol": "PDCD1",
        "hgnc": "HGNC:8760",
        "name": "programmed cell death 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pdcd1"
      },
      {
        "slug": "pfkm",
        "symbol": "PFKM",
        "hgnc": "HGNC:8877",
        "name": "phosphofructokinase, muscle",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pfkm"
      },
      {
        "slug": "pkd1",
        "symbol": "PKD1",
        "hgnc": "HGNC:9008",
        "name": "polycystin 1, transient receptor potential channel interacting",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pkd1"
      },
      {
        "slug": "pkd2",
        "symbol": "PKD2",
        "hgnc": "HGNC:9009",
        "name": "polycystin 2, transient receptor potential cation channel",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pkd2"
      },
      {
        "slug": "pxk",
        "symbol": "PXK",
        "hgnc": "HGNC:23326",
        "name": "PX domain containing serine/threonine kinase like",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pxk"
      },
      {
        "slug": "sat1",
        "symbol": "SAT1",
        "hgnc": "HGNC:10540",
        "name": "spermidine/spermine N1-acetyltransferase 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sat1"
      },
      {
        "slug": "serpinf2",
        "symbol": "SERPINF2",
        "hgnc": "HGNC:9075",
        "name": "serpin family F member 2",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/serpinf2"
      },
      {
        "slug": "slc7a7",
        "symbol": "SLC7A7",
        "hgnc": "HGNC:11065",
        "name": "solute carrier family 7 member 7",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slc7a7"
      },
      {
        "slug": "spp1",
        "symbol": "SPP1",
        "hgnc": "HGNC:11255",
        "name": "secreted phosphoprotein 1",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/spp1"
      },
      {
        "slug": "spry2",
        "symbol": "SPRY2",
        "hgnc": "HGNC:11270",
        "name": "sprouty RTK signaling antagonist 2",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/spry2"
      },
      {
        "slug": "stat4",
        "symbol": "STAT4",
        "hgnc": "HGNC:11365",
        "name": "signal transducer and activator of transcription 4",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/stat4"
      },
      {
        "slug": "stim1",
        "symbol": "STIM1",
        "hgnc": "HGNC:11386",
        "name": "stromal interaction molecule 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/stim1"
      },
      {
        "slug": "tlr7",
        "symbol": "TLR7",
        "hgnc": "HGNC:15631",
        "name": "toll like receptor 7",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tlr7"
      },
      {
        "slug": "tnfaip3",
        "symbol": "TNFAIP3",
        "hgnc": "HGNC:11896",
        "name": "TNF alpha induced protein 3",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tnfaip3"
      },
      {
        "slug": "tnfsf4",
        "symbol": "TNFSF4",
        "hgnc": "HGNC:11934",
        "name": "TNF superfamily member 4",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tnfsf4"
      },
      {
        "slug": "tnip1",
        "symbol": "TNIP1",
        "hgnc": "HGNC:16903",
        "name": "TNFAIP3 interacting protein 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tnip1"
      },
      {
        "slug": "trex1",
        "symbol": "TREX1",
        "hgnc": "HGNC:12269",
        "name": "three prime repair exonuclease 1",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/trex1"
      },
      {
        "slug": "tsc1",
        "symbol": "TSC1",
        "hgnc": "HGNC:12362",
        "name": "TSC complex subunit 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tsc1"
      },
      {
        "slug": "tsc2",
        "symbol": "TSC2",
        "hgnc": "HGNC:12363",
        "name": "TSC complex subunit 2",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tsc2"
      },
      {
        "slug": "ube2l3",
        "symbol": "UBE2L3",
        "hgnc": "HGNC:12488",
        "name": "ubiquitin conjugating enzyme E2 L3",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ube2l3"
      },
      {
        "slug": "yap1",
        "symbol": "YAP1",
        "hgnc": "HGNC:16262",
        "name": "Yes1 associated transcriptional regulator",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/yap1"
      },
      {
        "slug": "acp5",
        "symbol": "ACP5",
        "hgnc": "HGNC:124",
        "name": "acid phosphatase 5, tartrate resistant",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/acp5"
      },
      {
        "slug": "aggf1",
        "symbol": "AGGF1",
        "hgnc": "HGNC:24684",
        "name": "angiogenic factor with G-patch and FHA domains 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/aggf1"
      },
      {
        "slug": "bnc2",
        "symbol": "BNC2",
        "hgnc": "HGNC:30988",
        "name": "basonuclin zinc finger protein 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/bnc2"
      },
      {
        "slug": "cd109",
        "symbol": "CD109",
        "hgnc": "HGNC:21685",
        "name": "CD109 molecule",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cd109"
      },
      {
        "slug": "clec7a",
        "symbol": "CLEC7A",
        "hgnc": "HGNC:14558",
        "name": "C-type lectin domain containing 7A",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/clec7a"
      },
      {
        "slug": "dlst",
        "symbol": "DLST",
        "hgnc": "HGNC:2911",
        "name": "dihydrolipoamide S-succinyltransferase",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dlst"
      },
      {
        "slug": "dnmt3a",
        "symbol": "DNMT3A",
        "hgnc": "HGNC:2978",
        "name": "DNA methyltransferase 3 alpha",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dnmt3a"
      },
      {
        "slug": "dph1",
        "symbol": "DPH1",
        "hgnc": "HGNC:3003",
        "name": "diphthamide biosynthesis 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dph1"
      },
      {
        "slug": "epas1",
        "symbol": "EPAS1",
        "hgnc": "HGNC:3374",
        "name": "endothelial PAS domain protein 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/epas1"
      },
      {
        "slug": "f10",
        "symbol": "F10",
        "hgnc": "HGNC:3528",
        "name": "coagulation factor X",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/f10"
      },
      {
        "slug": "f5",
        "symbol": "F5",
        "hgnc": "HGNC:3542",
        "name": "coagulation factor V",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/f5"
      },
      {
        "slug": "f8",
        "symbol": "F8",
        "hgnc": "HGNC:3546",
        "name": "coagulation factor VIII",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/f8"
      },
      {
        "slug": "f9",
        "symbol": "F9",
        "hgnc": "HGNC:3551",
        "name": "coagulation factor IX",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/f9"
      },
      {
        "slug": "fan1",
        "symbol": "FAN1",
        "hgnc": "HGNC:29170",
        "name": "FANCD2 and FANCI associated nuclease 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fan1"
      },
      {
        "slug": "fcgr2c",
        "symbol": "FCGR2C",
        "hgnc": "HGNC:15626",
        "name": "Fc gamma receptor IIc (gene/pseudogene)",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fcgr2c"
      },
      {
        "slug": "fh",
        "symbol": "FH",
        "hgnc": "HGNC:3700",
        "name": "fumarate hydratase",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fh"
      },
      {
        "slug": "gba1",
        "symbol": "GBA1",
        "hgnc": "HGNC:4177",
        "name": "glucosylceramidase beta 1",
        "frequency": "occasional",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/gba1"
      },
      {
        "slug": "gp1ba",
        "symbol": "GP1BA",
        "hgnc": "HGNC:4439",
        "name": "glycoprotein Ib platelet subunit alpha",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gp1ba"
      },
      {
        "slug": "gp1bb",
        "symbol": "GP1BB",
        "hgnc": "HGNC:4440",
        "name": "glycoprotein Ib platelet subunit beta",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gp1bb"
      },
      {
        "slug": "hla-b",
        "symbol": "HLA-B",
        "hgnc": "HGNC:4932",
        "name": "major histocompatibility complex, class I, B",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hla-b"
      },
      {
        "slug": "il17f",
        "symbol": "IL17F",
        "hgnc": "HGNC:16404",
        "name": "interleukin 17F",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/il17f"
      },
      {
        "slug": "il17ra",
        "symbol": "IL17RA",
        "hgnc": "HGNC:5985",
        "name": "interleukin 17 receptor A",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/il17ra"
      },
      {
        "slug": "il17rc",
        "symbol": "IL17RC",
        "hgnc": "HGNC:18358",
        "name": "interleukin 17 receptor C",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/il17rc"
      },
      {
        "slug": "itga2",
        "symbol": "ITGA2",
        "hgnc": "HGNC:6137",
        "name": "integrin subunit alpha 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/itga2"
      },
      {
        "slug": "itga2b",
        "symbol": "ITGA2B",
        "hgnc": "HGNC:6138",
        "name": "integrin subunit alpha 2b",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/itga2b"
      },
      {
        "slug": "itgb3",
        "symbol": "ITGB3",
        "hgnc": "HGNC:6156",
        "name": "integrin subunit beta 3",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/itgb3"
      },
      {
        "slug": "kif1b",
        "symbol": "KIF1B",
        "hgnc": "HGNC:16636",
        "name": "kinesin family member 1B",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/kif1b"
      },
      {
        "slug": "lman1",
        "symbol": "LMAN1",
        "hgnc": "HGNC:6631",
        "name": "lectin, mannose binding 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lman1"
      },
      {
        "slug": "lmx1b",
        "symbol": "LMX1B",
        "hgnc": "HGNC:6654",
        "name": "LIM homeobox transcription factor 1 beta",
        "frequency": "occasional",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/lmx1b"
      },
      {
        "slug": "max",
        "symbol": "MAX",
        "hgnc": "HGNC:6913",
        "name": "MYC associated transcriptional regulator X",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/max"
      },
      {
        "slug": "mcfd2",
        "symbol": "MCFD2",
        "hgnc": "HGNC:18451",
        "name": "multiple coagulation factor deficiency 2, ER cargo receptor complex subunit",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mcfd2"
      },
      {
        "slug": "mdh2",
        "symbol": "MDH2",
        "hgnc": "HGNC:6971",
        "name": "malate dehydrogenase 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mdh2"
      },
      {
        "slug": "nf1",
        "symbol": "NF1",
        "hgnc": "HGNC:7765",
        "name": "neurofibromin 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nf1"
      },
      {
        "slug": "ocrl",
        "symbol": "OCRL",
        "hgnc": "HGNC:8108",
        "name": "OCRL inositol polyphosphate-5-phosphatase",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ocrl"
      },
      {
        "slug": "p4ha2",
        "symbol": "P4HA2",
        "hgnc": "HGNC:8547",
        "name": "prolyl 4-hydroxylase subunit alpha 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/p4ha2"
      },
      {
        "slug": "pik3ca",
        "symbol": "PIK3CA",
        "hgnc": "HGNC:8975",
        "name": "phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pik3ca"
      },
      {
        "slug": "ret",
        "symbol": "RET",
        "hgnc": "HGNC:9967",
        "name": "ret proto-oncogene",
        "frequency": "occasional",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/ret"
      },
      {
        "slug": "scarb2",
        "symbol": "SCARB2",
        "hgnc": "HGNC:1665",
        "name": "scavenger receptor class B member 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/scarb2"
      },
      {
        "slug": "sdha",
        "symbol": "SDHA",
        "hgnc": "HGNC:10680",
        "name": "succinate dehydrogenase complex flavoprotein subunit A",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sdha"
      },
      {
        "slug": "sdhaf2",
        "symbol": "SDHAF2",
        "hgnc": "HGNC:26034",
        "name": "succinate dehydrogenase complex assembly factor 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sdhaf2"
      },
      {
        "slug": "sdhb",
        "symbol": "SDHB",
        "hgnc": "HGNC:10681",
        "name": "succinate dehydrogenase complex iron sulfur subunit B",
        "frequency": "occasional",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/sdhb"
      },
      {
        "slug": "sdhc",
        "symbol": "SDHC",
        "hgnc": "HGNC:10682",
        "name": "succinate dehydrogenase complex subunit C",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sdhc"
      },
      {
        "slug": "sdhd",
        "symbol": "SDHD",
        "hgnc": "HGNC:10683",
        "name": "succinate dehydrogenase complex subunit D",
        "frequency": "occasional",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/sdhd"
      },
      {
        "slug": "slc22a12",
        "symbol": "SLC22A12",
        "hgnc": "HGNC:17989",
        "name": "solute carrier family 22 member 12",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slc22a12"
      },
      {
        "slug": "slc25a11",
        "symbol": "SLC25A11",
        "hgnc": "HGNC:10981",
        "name": "solute carrier family 25 member 11",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slc25a11"
      },
      {
        "slug": "slc2a9",
        "symbol": "SLC2A9",
        "hgnc": "HGNC:13446",
        "name": "solute carrier family 2 member 9",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slc2a9"
      },
      {
        "slug": "srebf1",
        "symbol": "SREBF1",
        "hgnc": "HGNC:11289",
        "name": "sterol regulatory element binding transcription factor 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/srebf1"
      },
      {
        "slug": "tmem127",
        "symbol": "TMEM127",
        "hgnc": "HGNC:26038",
        "name": "transmembrane protein 127",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tmem127"
      },
      {
        "slug": "traf3ip2",
        "symbol": "TRAF3IP2",
        "hgnc": "HGNC:1343",
        "name": "TRAF3 interacting protein 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/traf3ip2"
      },
      {
        "slug": "umod",
        "symbol": "UMOD",
        "hgnc": "HGNC:12559",
        "name": "uromodulin",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/umod"
      },
      {
        "slug": "vhl",
        "symbol": "VHL",
        "hgnc": "HGNC:12687",
        "name": "von Hippel-Lindau tumor suppressor",
        "frequency": "occasional",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/vhl"
      },
      {
        "slug": "bcor",
        "symbol": "BCOR",
        "hgnc": "HGNC:20893",
        "name": "BCL6 corepressor",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/bcor"
      },
      {
        "slug": "fip1l1",
        "symbol": "FIP1L1",
        "hgnc": "HGNC:19124",
        "name": "factor interacting with PAPOLA and CPSF1",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fip1l1"
      },
      {
        "slug": "irf2bp2",
        "symbol": "IRF2BP2",
        "hgnc": "HGNC:21729",
        "name": "interferon regulatory factor 2 binding protein 2",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/irf2bp2"
      },
      {
        "slug": "nabp1",
        "symbol": "NABP1",
        "hgnc": "HGNC:26232",
        "name": "nucleic acid binding protein 1",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nabp1"
      },
      {
        "slug": "npm1",
        "symbol": "NPM1",
        "hgnc": "HGNC:7910",
        "name": "nucleophosmin 1",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/npm1"
      },
      {
        "slug": "numa1",
        "symbol": "NUMA1",
        "hgnc": "HGNC:8059",
        "name": "nuclear mitotic apparatus protein 1",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/numa1"
      },
      {
        "slug": "pml",
        "symbol": "PML",
        "hgnc": "HGNC:9113",
        "name": "PML nuclear body scaffold",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pml"
      },
      {
        "slug": "prkar1a",
        "symbol": "PRKAR1A",
        "hgnc": "HGNC:9388",
        "name": "protein kinase cAMP-dependent type I regulatory subunit alpha",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/prkar1a"
      },
      {
        "slug": "rara",
        "symbol": "RARA",
        "hgnc": "HGNC:9864",
        "name": "retinoic acid receptor alpha",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rara"
      },
      {
        "slug": "slc34a2",
        "symbol": "SLC34A2",
        "hgnc": "HGNC:11020",
        "name": "solute carrier family 34 member 2",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slc34a2"
      },
      {
        "slug": "slc5a1",
        "symbol": "SLC5A1",
        "hgnc": "HGNC:11036",
        "name": "solute carrier family 5 member 1",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slc5a1"
      },
      {
        "slug": "sptbn1",
        "symbol": "SPTBN1",
        "hgnc": "HGNC:11275",
        "name": "spectrin beta, non-erythrocytic 1",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sptbn1"
      },
      {
        "slug": "stat3",
        "symbol": "STAT3",
        "hgnc": "HGNC:11364",
        "name": "signal transducer and activator of transcription 3",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/stat3"
      },
      {
        "slug": "stat5b",
        "symbol": "STAT5B",
        "hgnc": "HGNC:11367",
        "name": "signal transducer and activator of transcription 5B",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/stat5b"
      },
      {
        "slug": "tbl1xr1",
        "symbol": "TBL1XR1",
        "hgnc": "HGNC:29529",
        "name": "TBL1X/Y related 1",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tbl1xr1"
      },
      {
        "slug": "zbtb16",
        "symbol": "ZBTB16",
        "hgnc": "HGNC:12930",
        "name": "zinc finger and BTB domain containing 16",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/zbtb16"
      },
      {
        "slug": "c3",
        "symbol": "C3",
        "hgnc": "HGNC:1318",
        "name": "complement C3",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/c3"
      },
      {
        "slug": "cd2ap",
        "symbol": "CD2AP",
        "hgnc": "HGNC:14258",
        "name": "CD2 associated protein",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cd2ap"
      },
      {
        "slug": "cd46",
        "symbol": "CD46",
        "hgnc": "HGNC:6953",
        "name": "CD46 molecule",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cd46"
      },
      {
        "slug": "cfb",
        "symbol": "CFB",
        "hgnc": "HGNC:1037",
        "name": "complement factor B",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cfb"
      },
      {
        "slug": "cfh",
        "symbol": "CFH",
        "hgnc": "HGNC:4883",
        "name": "complement factor H",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cfh"
      },
      {
        "slug": "cfi",
        "symbol": "CFI",
        "hgnc": "HGNC:5394",
        "name": "complement factor I",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cfi"
      },
      {
        "slug": "cldn16",
        "symbol": "CLDN16",
        "hgnc": "HGNC:2037",
        "name": "claudin 16",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cldn16"
      },
      {
        "slug": "fga",
        "symbol": "FGA",
        "hgnc": "HGNC:3661",
        "name": "fibrinogen alpha chain",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fga"
      },
      {
        "slug": "gata3",
        "symbol": "GATA3",
        "hgnc": "HGNC:4172",
        "name": "GATA binding protein 3",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gata3"
      },
      {
        "slug": "grhpr",
        "symbol": "GRHPR",
        "hgnc": "HGNC:4570",
        "name": "glyoxylate and hydroxypyruvate reductase",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/grhpr"
      },
      {
        "slug": "hbb",
        "symbol": "HBB",
        "hgnc": "HGNC:4827",
        "name": "hemoglobin subunit beta",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hbb"
      },
      {
        "slug": "lmnb2",
        "symbol": "LMNB2",
        "hgnc": "HGNC:6638",
        "name": "lamin B2",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lmnb2"
      },
      {
        "slug": "mmachc",
        "symbol": "MMACHC",
        "hgnc": "HGNC:24525",
        "name": "metabolism of cobalamin associated C",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mmachc"
      },
      {
        "slug": "notch2",
        "symbol": "NOTCH2",
        "hgnc": "HGNC:7882",
        "name": "notch receptor 2",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/notch2"
      },
      {
        "slug": "nup133",
        "symbol": "NUP133",
        "hgnc": "HGNC:18016",
        "name": "nucleoporin 133",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nup133"
      },
      {
        "slug": "nup93",
        "symbol": "NUP93",
        "hgnc": "HGNC:28958",
        "name": "nucleoporin 93",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nup93"
      },
      {
        "slug": "prdx1",
        "symbol": "PRDX1",
        "hgnc": "HGNC:9352",
        "name": "peroxiredoxin 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/prdx1"
      },
      {
        "slug": "slc37a4",
        "symbol": "SLC37A4",
        "hgnc": "HGNC:4061",
        "name": "solute carrier family 37 member 4",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slc37a4"
      },
      {
        "slug": "thbd",
        "symbol": "THBD",
        "hgnc": "HGNC:11784",
        "name": "thrombomodulin",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/thbd"
      },
      {
        "slug": "umps",
        "symbol": "UMPS",
        "hgnc": "HGNC:12563",
        "name": "uridine monophosphate synthetase",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/umps"
      }
    ]
  }
}