{
  "url": "https://dantelabs.com/traits/duane-anomaly",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "duane-anomaly",
    "id": "HP:0009921",
    "name": "Duane anomaly",
    "definition": "A condition associated with a limitation of the horizontal ocular movement with retraction of the globe and narrowing of the palpebral fissure on adduction",
    "synonyms": [
      "Limited eye motility from Duane anomaly",
      "Limited eye movement from Duane anomaly"
    ],
    "systems": [
      {
        "slug": "abnormality-of-the-eye",
        "name": "Abnormality of the eye",
        "url": "https://dantelabs.com/traits/abnormality-of-the-eye"
      }
    ],
    "broader": [
      {
        "slug": "incomitant-strabismus",
        "name": "Incomitant strabismus",
        "url": "https://dantelabs.com/traits/incomitant-strabismus"
      }
    ],
    "narrower": [],
    "genes": [
      {
        "slug": "ccnq",
        "symbol": "CCNQ",
        "hgnc": "HGNC:28434",
        "name": "cyclin Q",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ccnq"
      },
      {
        "slug": "kdm2b",
        "symbol": "KDM2B",
        "hgnc": "HGNC:13610",
        "name": "lysine demethylase 2B",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/kdm2b"
      },
      {
        "slug": "piezo2",
        "symbol": "PIEZO2",
        "hgnc": "HGNC:26270",
        "name": "piezo type mechanosensitive ion channel component 2",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/piezo2"
      },
      {
        "slug": "polr1a",
        "symbol": "POLR1A",
        "hgnc": "HGNC:17264",
        "name": "RNA polymerase I subunit A",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/polr1a"
      },
      {
        "slug": "uba2",
        "symbol": "UBA2",
        "hgnc": "HGNC:30661",
        "name": "ubiquitin like modifier activating enzyme 2",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/uba2"
      },
      {
        "slug": "chn1",
        "symbol": "CHN1",
        "hgnc": "HGNC:1943",
        "name": "chimerin 1",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/chn1"
      },
      {
        "slug": "mafb",
        "symbol": "MAFB",
        "hgnc": "HGNC:6408",
        "name": "MAF bZIP transcription factor B",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/mafb"
      },
      {
        "slug": "sall4",
        "symbol": "SALL4",
        "hgnc": "HGNC:15924",
        "name": "spalt like transcription factor 4",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/sall4"
      },
      {
        "slug": "col25a1",
        "symbol": "COL25A1",
        "hgnc": "HGNC:18603",
        "name": "collagen type XXV alpha 1 chain",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/col25a1"
      },
      {
        "slug": "dcc",
        "symbol": "DCC",
        "hgnc": "HGNC:2701",
        "name": "DCC netrin 1 receptor",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dcc"
      },
      {
        "slug": "nsmf",
        "symbol": "NSMF",
        "hgnc": "HGNC:29843",
        "name": "NMDA receptor synaptonuclear signaling and neuronal migration factor",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nsmf"
      },
      {
        "slug": "robo3",
        "symbol": "ROBO3",
        "hgnc": "HGNC:13433",
        "name": "roundabout guidance receptor 3",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/robo3"
      },
      {
        "slug": "ackr3",
        "symbol": "ACKR3",
        "hgnc": "HGNC:23692",
        "name": "atypical chemokine receptor 3",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ackr3"
      },
      {
        "slug": "cep120",
        "symbol": "CEP120",
        "hgnc": "HGNC:26690",
        "name": "centrosomal protein 120",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cep120"
      },
      {
        "slug": "cspp1",
        "symbol": "CSPP1",
        "hgnc": "HGNC:26193",
        "name": "centrosome and spindle pole associated protein 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cspp1"
      },
      {
        "slug": "fbxo11",
        "symbol": "FBXO11",
        "hgnc": "HGNC:13590",
        "name": "F-box protein 11",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fbxo11"
      },
      {
        "slug": "kcnn2",
        "symbol": "KCNN2",
        "hgnc": "HGNC:6291",
        "name": "potassium calcium-activated channel subfamily N member 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/kcnn2"
      },
      {
        "slug": "kiaa0586",
        "symbol": "KIAA0586",
        "hgnc": "HGNC:19960",
        "name": "KIAA0586",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/kiaa0586"
      },
      {
        "slug": "med13",
        "symbol": "MED13",
        "hgnc": "HGNC:22474",
        "name": "mediator complex subunit 13",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/med13"
      },
      {
        "slug": "sall1",
        "symbol": "SALL1",
        "hgnc": "HGNC:10524",
        "name": "spalt like transcription factor 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sall1"
      },
      {
        "slug": "dnm1l",
        "symbol": "DNM1L",
        "hgnc": "HGNC:2973",
        "name": "dynamin 1L",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dnm1l"
      },
      {
        "slug": "gja5",
        "symbol": "GJA5",
        "hgnc": "HGNC:4279",
        "name": "gap junction protein alpha 5",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gja5"
      },
      {
        "slug": "gja8",
        "symbol": "GJA8",
        "hgnc": "HGNC:4281",
        "name": "gap junction protein alpha 8",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gja8"
      },
      {
        "slug": "opa1",
        "symbol": "OPA1",
        "hgnc": "HGNC:8140",
        "name": "OPA1 mitochondrial dynamin like GTPase",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/opa1"
      },
      {
        "slug": "ppib",
        "symbol": "PPIB",
        "hgnc": "HGNC:9255",
        "name": "peptidylprolyl isomerase B",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ppib"
      },
      {
        "slug": "arx",
        "symbol": "ARX",
        "hgnc": "HGNC:18060",
        "name": "aristaless related homeobox",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/arx"
      },
      {
        "slug": "hoxa1",
        "symbol": "HOXA1",
        "hgnc": "HGNC:5099",
        "name": "homeobox A1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hoxa1"
      },
      {
        "slug": "mn1",
        "symbol": "MN1",
        "hgnc": "HGNC:7180",
        "name": "MN1 proto-oncogene, transcriptional regulator",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mn1"
      },
      {
        "slug": "zmiz1",
        "symbol": "ZMIZ1",
        "hgnc": "HGNC:16493",
        "name": "zinc finger MIZ-type containing 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/zmiz1"
      }
    ]
  }
}