{
  "url": "https://dantelabs.com/traits/decreased-circulating-complement-c8-concentration",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "decreased-circulating-complement-c8-concentration",
    "id": "HP:0004434",
    "name": "Decreased circulating complement C8 concentration",
    "definition": "Concentration of the complement component C8 in the blood circulation below the lower limit of normal.",
    "synonyms": [
      "C8 deficiency",
      "Decreased serum complement C8"
    ],
    "systems": [
      {
        "slug": "abnormality-of-the-immune-system",
        "name": "Abnormality of the immune system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-immune-system"
      }
    ],
    "broader": [
      {
        "slug": "decreased-circulating-terminal-complement-component-concentration",
        "name": "Decreased circulating terminal complement component concentration",
        "url": "https://dantelabs.com/traits/decreased-circulating-terminal-complement-component-concentration"
      }
    ],
    "narrower": [],
    "genes": [
      {
        "slug": "c8a",
        "symbol": "C8A",
        "hgnc": "HGNC:1352",
        "name": "complement C8 alpha chain",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/c8a"
      },
      {
        "slug": "c8b",
        "symbol": "C8B",
        "hgnc": "HGNC:1353",
        "name": "complement C8 beta chain",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/c8b"
      }
    ]
  }
}