{
  "url": "https://dantelabs.com/traits/colon-perforation",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "colon-perforation",
    "id": "HP:0031369",
    "name": "Colon perforation",
    "definition": "A hole (perforation) in the wall of the colon.",
    "synonyms": [
      "Perforation of the colon"
    ],
    "systems": [
      {
        "slug": "abnormality-of-the-digestive-system",
        "name": "Abnormality of the digestive system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-digestive-system"
      }
    ],
    "broader": [
      {
        "slug": "intestinal-perforation",
        "name": "Intestinal perforation",
        "url": "https://dantelabs.com/traits/intestinal-perforation"
      }
    ],
    "narrower": [],
    "genes": [
      {
        "slug": "col3a1",
        "symbol": "COL3A1",
        "hgnc": "HGNC:2201",
        "name": "collagen type III alpha 1 chain",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/col3a1"
      },
      {
        "slug": "abcd1",
        "symbol": "ABCD1",
        "hgnc": "HGNC:61",
        "name": "ATP binding cassette subfamily D member 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/abcd1"
      },
      {
        "slug": "atp7a",
        "symbol": "ATP7A",
        "hgnc": "HGNC:869",
        "name": "ATPase copper transporting alpha",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/atp7a"
      },
      {
        "slug": "ece1",
        "symbol": "ECE1",
        "hgnc": "HGNC:3146",
        "name": "endothelin converting enzyme 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ece1"
      },
      {
        "slug": "edn3",
        "symbol": "EDN3",
        "hgnc": "HGNC:3178",
        "name": "endothelin 3",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/edn3"
      },
      {
        "slug": "ednrb",
        "symbol": "EDNRB",
        "hgnc": "HGNC:3180",
        "name": "endothelin receptor type B",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ednrb"
      },
      {
        "slug": "erbb2",
        "symbol": "ERBB2",
        "hgnc": "HGNC:3430",
        "name": "erb-b2 receptor tyrosine kinase 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/erbb2"
      },
      {
        "slug": "erbb3",
        "symbol": "ERBB3",
        "hgnc": "HGNC:3431",
        "name": "erb-b2 receptor tyrosine kinase 3",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/erbb3"
      },
      {
        "slug": "gata6",
        "symbol": "GATA6",
        "hgnc": "HGNC:4174",
        "name": "GATA binding protein 6",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gata6"
      },
      {
        "slug": "gdnf",
        "symbol": "GDNF",
        "hgnc": "HGNC:4232",
        "name": "glial cell derived neurotrophic factor",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gdnf"
      },
      {
        "slug": "nrtn",
        "symbol": "NRTN",
        "hgnc": "HGNC:8007",
        "name": "neurturin",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nrtn"
      },
      {
        "slug": "ret",
        "symbol": "RET",
        "hgnc": "HGNC:9967",
        "name": "ret proto-oncogene",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ret"
      },
      {
        "slug": "sema3c",
        "symbol": "SEMA3C",
        "hgnc": "HGNC:10725",
        "name": "semaphorin 3C",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sema3c"
      },
      {
        "slug": "sema3d",
        "symbol": "SEMA3D",
        "hgnc": "HGNC:10726",
        "name": "semaphorin 3D",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sema3d"
      },
      {
        "slug": "smo",
        "symbol": "SMO",
        "hgnc": "HGNC:11119",
        "name": "smoothened, frizzled class receptor",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/smo"
      },
      {
        "slug": "srebf1",
        "symbol": "SREBF1",
        "hgnc": "HGNC:11289",
        "name": "sterol regulatory element binding transcription factor 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/srebf1"
      }
    ]
  }
}