{
  "url": "https://dantelabs.com/traits/amelia",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "amelia",
    "id": "HP:0009827",
    "name": "Amelia",
    "definition": "Congenital absence (aplasia) of one or more limbs.",
    "synonyms": [],
    "systems": [
      {
        "slug": "abnormality-of-limbs",
        "name": "Abnormality of limbs",
        "url": "https://dantelabs.com/traits/abnormality-of-limbs"
      },
      {
        "slug": "abnormality-of-the-musculoskeletal-system",
        "name": "Abnormality of the musculoskeletal system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-musculoskeletal-system"
      }
    ],
    "broader": [
      {
        "slug": "aplasia-hypoplasia-of-the-extremities",
        "name": "Absent/small extremities",
        "url": "https://dantelabs.com/traits/aplasia-hypoplasia-of-the-extremities"
      }
    ],
    "narrower": [
      {
        "slug": "amelia-involving-the-upper-limbs",
        "name": "Amelia involving the upper limbs",
        "genes": 4,
        "url": "https://dantelabs.com/traits/amelia-involving-the-upper-limbs"
      },
      {
        "slug": "tetraamelia",
        "name": "Tetraamelia",
        "genes": 3,
        "url": "https://dantelabs.com/traits/tetraamelia"
      },
      {
        "slug": "amelia-involving-the-lower-limbs",
        "name": "Amelia involving the lower limbs",
        "genes": 1,
        "url": "https://dantelabs.com/traits/amelia-involving-the-lower-limbs"
      }
    ],
    "genes": [
      {
        "slug": "rspo2",
        "symbol": "RSPO2",
        "hgnc": "HGNC:28583",
        "name": "R-spondin 2",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rspo2"
      },
      {
        "slug": "nsdhl",
        "symbol": "NSDHL",
        "hgnc": "HGNC:13398",
        "name": "NAD(P) dependent 3-beta-hydroxysteroid dehydrogenase NSDHL",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nsdhl"
      },
      {
        "slug": "tbx4",
        "symbol": "TBX4",
        "hgnc": "HGNC:11603",
        "name": "T-box transcription factor 4",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tbx4"
      }
    ]
  }
}