{
  "url": "https://dantelabs.com/traits/abnormal-sperm-motility",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "abnormal-sperm-motility",
    "id": "HP:0012206",
    "name": "Abnormal sperm motility",
    "definition": "An anomaly of the mobility of ejaculated sperm.",
    "synonyms": [],
    "systems": [
      {
        "slug": "abnormality-of-the-genitourinary-system",
        "name": "Abnormality of the genitourinary system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-genitourinary-system"
      }
    ],
    "broader": [
      {
        "slug": "abnormal-sperm-physiology",
        "name": "Abnormal sperm physiology",
        "url": "https://dantelabs.com/traits/abnormal-sperm-physiology"
      }
    ],
    "narrower": [
      {
        "slug": "reduced-sperm-motility",
        "name": "Reduced sperm motility",
        "genes": 67,
        "url": "https://dantelabs.com/traits/reduced-sperm-motility"
      },
      {
        "slug": "reduced-progressive-sperm-motility",
        "name": "Reduced progressive sperm motility",
        "genes": 27,
        "url": "https://dantelabs.com/traits/reduced-progressive-sperm-motility"
      }
    ],
    "genes": [
      {
        "slug": "brwd1",
        "symbol": "BRWD1",
        "hgnc": "HGNC:12760",
        "name": "bromodomain and WD repeat domain containing 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/brwd1"
      },
      {
        "slug": "ccdc39",
        "symbol": "CCDC39",
        "hgnc": "HGNC:25244",
        "name": "coiled-coil domain 39 molecular ruler complex subunit",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ccdc39"
      },
      {
        "slug": "ccdc40",
        "symbol": "CCDC40",
        "hgnc": "HGNC:26090",
        "name": "coiled-coil domain 40 molecular ruler complex subunit",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ccdc40"
      },
      {
        "slug": "ccno",
        "symbol": "CCNO",
        "hgnc": "HGNC:18576",
        "name": "cyclin O",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ccno"
      },
      {
        "slug": "cfap221",
        "symbol": "CFAP221",
        "hgnc": "HGNC:33720",
        "name": "cilia and flagella associated protein 221",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cfap221"
      },
      {
        "slug": "cfap298",
        "symbol": "CFAP298",
        "hgnc": "HGNC:1301",
        "name": "cilia and flagella associated protein 298",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cfap298"
      },
      {
        "slug": "cfap300",
        "symbol": "CFAP300",
        "hgnc": "HGNC:28188",
        "name": "cilia and flagella associated protein 300",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cfap300"
      },
      {
        "slug": "cfap74",
        "symbol": "CFAP74",
        "hgnc": "HGNC:29368",
        "name": "cilia and flagella associated protein 74",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cfap74"
      },
      {
        "slug": "clxn",
        "symbol": "CLXN",
        "hgnc": "HGNC:25678",
        "name": "calaxin",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/clxn"
      },
      {
        "slug": "daw1",
        "symbol": "DAW1",
        "hgnc": "HGNC:26383",
        "name": "dynein assembly factor with WD repeats 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/daw1"
      },
      {
        "slug": "dnaaf1",
        "symbol": "DNAAF1",
        "hgnc": "HGNC:30539",
        "name": "dynein axonemal assembly factor 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dnaaf1"
      },
      {
        "slug": "dnaaf11",
        "symbol": "DNAAF11",
        "hgnc": "HGNC:16725",
        "name": "dynein axonemal assembly factor 11",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dnaaf11"
      },
      {
        "slug": "dnaaf19",
        "symbol": "DNAAF19",
        "hgnc": "HGNC:32700",
        "name": "dynein axonemal assembly factor 19",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dnaaf19"
      },
      {
        "slug": "dnaaf2",
        "symbol": "DNAAF2",
        "hgnc": "HGNC:20188",
        "name": "dynein axonemal assembly factor 2",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dnaaf2"
      },
      {
        "slug": "dnaaf3",
        "symbol": "DNAAF3",
        "hgnc": "HGNC:30492",
        "name": "dynein axonemal assembly factor 3",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dnaaf3"
      },
      {
        "slug": "dnaaf4",
        "symbol": "DNAAF4",
        "hgnc": "HGNC:21493",
        "name": "dynein axonemal assembly factor 4",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dnaaf4"
      },
      {
        "slug": "dnaaf5",
        "symbol": "DNAAF5",
        "hgnc": "HGNC:26013",
        "name": "dynein axonemal assembly factor 5",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dnaaf5"
      },
      {
        "slug": "dnaaf6",
        "symbol": "DNAAF6",
        "hgnc": "HGNC:28570",
        "name": "dynein axonemal assembly factor 6",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dnaaf6"
      },
      {
        "slug": "dnah1",
        "symbol": "DNAH1",
        "hgnc": "HGNC:2940",
        "name": "dynein axonemal heavy chain 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dnah1"
      },
      {
        "slug": "dnah11",
        "symbol": "DNAH11",
        "hgnc": "HGNC:2942",
        "name": "dynein axonemal heavy chain 11",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dnah11"
      },
      {
        "slug": "dnah5",
        "symbol": "DNAH5",
        "hgnc": "HGNC:2950",
        "name": "dynein axonemal heavy chain 5",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dnah5"
      },
      {
        "slug": "dnah7",
        "symbol": "DNAH7",
        "hgnc": "HGNC:18661",
        "name": "dynein axonemal heavy chain 7",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dnah7"
      },
      {
        "slug": "dnah9",
        "symbol": "DNAH9",
        "hgnc": "HGNC:2953",
        "name": "dynein axonemal heavy chain 9",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dnah9"
      },
      {
        "slug": "dnai1",
        "symbol": "DNAI1",
        "hgnc": "HGNC:2954",
        "name": "dynein axonemal intermediate chain 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dnai1"
      },
      {
        "slug": "dnai2",
        "symbol": "DNAI2",
        "hgnc": "HGNC:18744",
        "name": "dynein axonemal intermediate chain 2",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dnai2"
      },
      {
        "slug": "dnajb13",
        "symbol": "DNAJB13",
        "hgnc": "HGNC:30718",
        "name": "DnaJ heat shock protein family (Hsp40) member B13",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dnajb13"
      },
      {
        "slug": "dnal1",
        "symbol": "DNAL1",
        "hgnc": "HGNC:23247",
        "name": "dynein axonemal light chain 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dnal1"
      },
      {
        "slug": "drc1",
        "symbol": "DRC1",
        "hgnc": "HGNC:24245",
        "name": "dynein regulatory complex subunit 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/drc1"
      },
      {
        "slug": "drc2",
        "symbol": "DRC2",
        "hgnc": "HGNC:29937",
        "name": "dynein regulatory complex subunit 2",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/drc2"
      },
      {
        "slug": "drc4",
        "symbol": "DRC4",
        "hgnc": "HGNC:4166",
        "name": "dynein regulatory complex subunit 4",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/drc4"
      },
      {
        "slug": "foxj1",
        "symbol": "FOXJ1",
        "hgnc": "HGNC:3816",
        "name": "forkhead box J1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/foxj1"
      },
      {
        "slug": "gas2l2",
        "symbol": "GAS2L2",
        "hgnc": "HGNC:24846",
        "name": "growth arrest specific 2 like 2",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gas2l2"
      },
      {
        "slug": "hydin",
        "symbol": "HYDIN",
        "hgnc": "HGNC:19368",
        "name": "HYDIN axonemal central pair apparatus protein",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hydin"
      },
      {
        "slug": "lrrc56",
        "symbol": "LRRC56",
        "hgnc": "HGNC:25430",
        "name": "leucine rich repeat containing 56",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lrrc56"
      },
      {
        "slug": "mcidas",
        "symbol": "MCIDAS",
        "hgnc": "HGNC:40050",
        "name": "multiciliate differentiation and DNA synthesis associated cell cycle protein",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mcidas"
      },
      {
        "slug": "nek10",
        "symbol": "NEK10",
        "hgnc": "HGNC:18592",
        "name": "NIMA related kinase 10",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nek10"
      },
      {
        "slug": "nme5",
        "symbol": "NME5",
        "hgnc": "HGNC:7853",
        "name": "NME/NM23 family member 5",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nme5"
      },
      {
        "slug": "nme8",
        "symbol": "NME8",
        "hgnc": "HGNC:16473",
        "name": "NME/NM23 family member 8",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nme8"
      },
      {
        "slug": "odad1",
        "symbol": "ODAD1",
        "hgnc": "HGNC:26560",
        "name": "outer dynein arm docking complex subunit 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/odad1"
      },
      {
        "slug": "odad2",
        "symbol": "ODAD2",
        "hgnc": "HGNC:25583",
        "name": "outer dynein arm docking complex subunit 2",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/odad2"
      },
      {
        "slug": "odad3",
        "symbol": "ODAD3",
        "hgnc": "HGNC:28303",
        "name": "outer dynein arm docking complex subunit 3",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/odad3"
      },
      {
        "slug": "odad4",
        "symbol": "ODAD4",
        "hgnc": "HGNC:25280",
        "name": "outer dynein arm docking complex subunit 4",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/odad4"
      },
      {
        "slug": "ofd1",
        "symbol": "OFD1",
        "hgnc": "HGNC:2567",
        "name": "OFD1 centriole and centriolar satellite protein",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ofd1"
      },
      {
        "slug": "rpgr",
        "symbol": "RPGR",
        "hgnc": "HGNC:10295",
        "name": "retinitis pigmentosa GTPase regulator",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rpgr"
      },
      {
        "slug": "rsph1",
        "symbol": "RSPH1",
        "hgnc": "HGNC:12371",
        "name": "radial spoke head component 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rsph1"
      },
      {
        "slug": "rsph3",
        "symbol": "RSPH3",
        "hgnc": "HGNC:21054",
        "name": "radial spoke head 3",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rsph3"
      },
      {
        "slug": "rsph4a",
        "symbol": "RSPH4A",
        "hgnc": "HGNC:21558",
        "name": "radial spoke head component 4A",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rsph4a"
      },
      {
        "slug": "rsph9",
        "symbol": "RSPH9",
        "hgnc": "HGNC:21057",
        "name": "radial spoke head component 9",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rsph9"
      },
      {
        "slug": "spag1",
        "symbol": "SPAG1",
        "hgnc": "HGNC:11212",
        "name": "sperm associated antigen 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/spag1"
      },
      {
        "slug": "spef2",
        "symbol": "SPEF2",
        "hgnc": "HGNC:26293",
        "name": "sperm flagellar and cilia associated 2",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/spef2"
      },
      {
        "slug": "stk36",
        "symbol": "STK36",
        "hgnc": "HGNC:17209",
        "name": "serine/threonine kinase 36",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/stk36"
      },
      {
        "slug": "ttc12",
        "symbol": "TTC12",
        "hgnc": "HGNC:23700",
        "name": "tetratricopeptide repeat domain 12",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ttc12"
      },
      {
        "slug": "zmynd10",
        "symbol": "ZMYND10",
        "hgnc": "HGNC:19412",
        "name": "zinc finger MYND-type containing 10",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/zmynd10"
      },
      {
        "slug": "pde11a",
        "symbol": "PDE11A",
        "hgnc": "HGNC:8773",
        "name": "phosphodiesterase 11A",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pde11a"
      },
      {
        "slug": "prkar1a",
        "symbol": "PRKAR1A",
        "hgnc": "HGNC:9388",
        "name": "protein kinase cAMP-dependent type I regulatory subunit alpha",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/prkar1a"
      }
    ]
  }
}