{
  "url": "https://dantelabs.com/traits/abnormal-circulating-hormone-concentration",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "abnormal-circulating-hormone-concentration",
    "id": "HP:0003117",
    "name": "Abnormality of circulating hormone level",
    "label": "Abnormal circulating hormone concentration",
    "definition": "Concentration of a hormone in the blood circulation outside of normal limits.",
    "synonyms": [
      "Abnormal circulating hormone level"
    ],
    "systems": [
      {
        "slug": "abnormality-of-the-endocrine-system",
        "name": "Abnormality of the endocrine system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-endocrine-system"
      }
    ],
    "broader": [
      {
        "slug": "abnormality-of-the-endocrine-system",
        "name": "Abnormality of the endocrine system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-endocrine-system"
      }
    ],
    "narrower": [
      {
        "slug": "abnormal-circulating-insulin-concentration",
        "name": "Abnormal circulating insulin concentration",
        "genes": 16,
        "url": "https://dantelabs.com/traits/abnormal-circulating-insulin-concentration"
      },
      {
        "slug": "increased-serum-serotonin",
        "name": "Increased serum serotonin",
        "genes": 11,
        "url": "https://dantelabs.com/traits/increased-serum-serotonin"
      },
      {
        "slug": "abnormal-circulating-calcium-phosphate-regulating-hormone-concentration",
        "name": "Abnormal circulating calcium-phosphate regulating hormone concentration",
        "genes": 7,
        "url": "https://dantelabs.com/traits/abnormal-circulating-calcium-phosphate-regulating-hormone-concentration"
      },
      {
        "slug": "abnormal-circulating-adrenocorticotropin-concentration",
        "name": "Abnormal circulating adrenocorticotropin concentration",
        "genes": 5,
        "url": "https://dantelabs.com/traits/abnormal-circulating-adrenocorticotropin-concentration"
      },
      {
        "slug": "abnormal-circulating-osteocalcin-level",
        "name": "Abnormal circulating osteocalcin level",
        "genes": 2,
        "url": "https://dantelabs.com/traits/abnormal-circulating-osteocalcin-level"
      },
      {
        "slug": "abnormal-circulating-thyroid-hormone-concentration",
        "name": "Abnormal circulating thyroid hormone concentration",
        "genes": 2,
        "url": "https://dantelabs.com/traits/abnormal-circulating-thyroid-hormone-concentration"
      },
      {
        "slug": "abnormal-circulating-leptin-concentration",
        "name": "Abnormal circulating leptin concentration",
        "genes": 1,
        "url": "https://dantelabs.com/traits/abnormal-circulating-leptin-concentration"
      },
      {
        "slug": "decreased-circulating-thrombopoietin-concentration",
        "name": "Decreased circulating thrombopoietin concentration",
        "genes": 1,
        "url": "https://dantelabs.com/traits/decreased-circulating-thrombopoietin-concentration"
      },
      {
        "slug": "elevated-circulating-proinsulin-concentration",
        "name": "Elevated circulating proinsulin concentration",
        "genes": 1,
        "url": "https://dantelabs.com/traits/elevated-circulating-proinsulin-concentration"
      },
      {
        "slug": "reduced-circulating-insulin-like-growth-factor-2-concentration",
        "name": "Reduced circulating insulin-like growth factor 2 concentration",
        "genes": 1,
        "url": "https://dantelabs.com/traits/reduced-circulating-insulin-like-growth-factor-2-concentration"
      },
      {
        "slug": "abnormal-adiponectin-level",
        "name": "Abnormal adiponectin level",
        "genes": 0,
        "url": "https://dantelabs.com/traits/abnormal-adiponectin-level"
      },
      {
        "slug": "abnormal-circulating-antimullerian-hormone-concentration",
        "name": "Abnormal circulating antimullerian hormone concentration",
        "genes": 0,
        "url": "https://dantelabs.com/traits/abnormal-circulating-antimullerian-hormone-concentration"
      },
      {
        "slug": "abnormal-circulating-catecholamine-concentration",
        "name": "Abnormal circulating catecholamine concentration",
        "genes": 0,
        "url": "https://dantelabs.com/traits/abnormal-circulating-catecholamine-concentration"
      },
      {
        "slug": "abnormal-circulating-erythropoietin-concentration",
        "name": "Abnormal circulating erythropoietin concentration",
        "genes": 0,
        "url": "https://dantelabs.com/traits/abnormal-circulating-erythropoietin-concentration"
      },
      {
        "slug": "abnormal-circulating-fibroblast-growth-factor-23-concentration",
        "name": "Abnormal circulating fibroblast growth factor 23 concentration",
        "genes": 0,
        "url": "https://dantelabs.com/traits/abnormal-circulating-fibroblast-growth-factor-23-concentration"
      },
      {
        "slug": "abnormal-circulating-gastrin-concentration",
        "name": "Abnormal circulating gastrin concentration",
        "genes": 0,
        "url": "https://dantelabs.com/traits/abnormal-circulating-gastrin-concentration"
      },
      {
        "slug": "abnormal-circulating-glucagon-concentration",
        "name": "Abnormal circulating glucagon concentration",
        "genes": 0,
        "url": "https://dantelabs.com/traits/abnormal-circulating-glucagon-concentration"
      },
      {
        "slug": "abnormal-circulating-gonadotropin-concentration",
        "name": "Abnormal circulating gonadotropin concentration",
        "genes": 0,
        "url": "https://dantelabs.com/traits/abnormal-circulating-gonadotropin-concentration"
      },
      {
        "slug": "abnormal-circulating-growth-hormone-concentration",
        "name": "Abnormal circulating growth hormone concentration",
        "genes": 0,
        "url": "https://dantelabs.com/traits/abnormal-circulating-growth-hormone-concentration"
      },
      {
        "slug": "abnormal-circulating-inhibin-level",
        "name": "Abnormal circulating inhibin level",
        "genes": 0,
        "url": "https://dantelabs.com/traits/abnormal-circulating-inhibin-level"
      },
      {
        "slug": "abnormal-circulating-insulin-like-growth-factor-1-concentration",
        "name": "Abnormal circulating insulin-like growth factor 1 concentration",
        "genes": 0,
        "url": "https://dantelabs.com/traits/abnormal-circulating-insulin-like-growth-factor-1-concentration"
      },
      {
        "slug": "abnormal-circulating-sex-hormone-concentration",
        "name": "Abnormal circulating sex hormone concentration",
        "genes": 0,
        "url": "https://dantelabs.com/traits/abnormal-circulating-sex-hormone-concentration"
      },
      {
        "slug": "abnormal-circulating-thyroid-stimulating-hormone-concentration",
        "name": "Abnormal circulating thyroid-stimulating hormone concentration",
        "genes": 0,
        "url": "https://dantelabs.com/traits/abnormal-circulating-thyroid-stimulating-hormone-concentration"
      },
      {
        "slug": "abnormal-gonadotropin-releasing-hormone-concentration",
        "name": "Abnormal gonadotropin-releasing hormone concentration",
        "genes": 0,
        "url": "https://dantelabs.com/traits/abnormal-gonadotropin-releasing-hormone-concentration"
      },
      {
        "slug": "abnormal-pituitary-glycoprotein-hormone-alpha-subunit-level",
        "name": "Abnormal pituitary glycoprotein hormone alpha subunit level",
        "genes": 0,
        "url": "https://dantelabs.com/traits/abnormal-pituitary-glycoprotein-hormone-alpha-subunit-level"
      },
      {
        "slug": "abnormality-of-circulating-glucocorticoid-level",
        "name": "Abnormality of circulating glucocorticoid level",
        "genes": 0,
        "url": "https://dantelabs.com/traits/abnormality-of-circulating-glucocorticoid-level"
      }
    ],
    "genes": [
      {
        "slug": "esr1",
        "symbol": "ESR1",
        "hgnc": "HGNC:3467",
        "name": "estrogen receptor 1",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/esr1"
      },
      {
        "slug": "plin1",
        "symbol": "PLIN1",
        "hgnc": "HGNC:9076",
        "name": "perilipin 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/plin1"
      }
    ]
  }
}