{
  "url": "https://dantelabs.com/traits/abnormal-circulating-enzyme-concentration",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "abnormal-circulating-enzyme-concentration",
    "id": "HP:0011021",
    "name": "Abnormal circulating enzyme concentration",
    "definition": "Any deviation from the normal concentration of an enzyme in the blood circulation.",
    "synonyms": [
      "Abnormality of circulating enzyme level"
    ],
    "systems": [
      {
        "slug": "abnormality-of-metabolism-homeostasis",
        "name": "Laboratory abnormality",
        "url": "https://dantelabs.com/traits/abnormality-of-metabolism-homeostasis"
      }
    ],
    "broader": [
      {
        "slug": "abnormal-circulating-protein-concentration",
        "name": "Blood protein disease",
        "url": "https://dantelabs.com/traits/abnormal-circulating-protein-concentration"
      }
    ],
    "narrower": [
      {
        "slug": "abnormal-circulating-creatine-kinase-activity",
        "name": "Abnormal levels of creatine kinase in blood",
        "genes": 30,
        "url": "https://dantelabs.com/traits/abnormal-circulating-creatine-kinase-activity"
      },
      {
        "slug": "elevated-circulating-beta-hexosaminidase-activity",
        "name": "Elevated circulating beta-hexosaminidase activity",
        "genes": 2,
        "url": "https://dantelabs.com/traits/elevated-circulating-beta-hexosaminidase-activity"
      }
    ],
    "genes": [
      {
        "slug": "aass",
        "symbol": "AASS",
        "hgnc": "HGNC:17366",
        "name": "aminoadipate-semialdehyde synthase",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/aass"
      },
      {
        "slug": "agxt",
        "symbol": "AGXT",
        "hgnc": "HGNC:341",
        "name": "alanine--glyoxylate aminotransferase",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/agxt"
      },
      {
        "slug": "dcxr",
        "symbol": "DCXR",
        "hgnc": "HGNC:18985",
        "name": "dicarbonyl and L-xylulose reductase",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dcxr"
      },
      {
        "slug": "sugct",
        "symbol": "SUGCT",
        "hgnc": "HGNC:16001",
        "name": "succinyl-CoA:glutarate-CoA transferase",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sugct"
      }
    ]
  }
}