{
  "url": "https://dantelabs.com/pt/genes/ubb",
  "gene": {
    "slug": "ubb",
    "symbol": "UBB",
    "name": "ubiquitin B",
    "hgnc": "HGNC:12463",
    "summary": null,
    "location": "17p11.2",
    "locusType": "gene with protein product",
    "aliases": [
      "MGC8385",
      "FLJ25987"
    ],
    "previousSymbols": [],
    "ensemblId": "ENSG00000170315",
    "entrezId": 7314,
    "omim": [
      "191339"
    ],
    "uniprot": [
      "P0CG47"
    ],
    "model": {
      "build": "GRCh38",
      "release": "v1.5",
      "chrom": "17",
      "start": 16381091,
      "end": 16382740,
      "strand": "+",
      "ensemblTranscript": "ENST00000302182.8",
      "refseqTranscript": "NM_018955.4",
      "ensemblProtein": "ENSP00000304697.3",
      "refseqProtein": "NP_061828.1",
      "exons": [
        {
          "start": 16381091,
          "end": 16381184
        },
        {
          "start": 16381902,
          "end": 16382740
        }
      ],
      "cds": {
        "start": 16381908,
        "end": 16382597
      }
    },
    "grch37": {
      "build": "GRCh37",
      "release": "87",
      "chrom": "17",
      "start": 16284112,
      "end": 16286059,
      "strand": "+"
    },
    "neighbourhood": {
      "release": "116",
      "start": 15881916,
      "end": 16881915,
      "genes": [
        {
          "symbol": "ADORA2B",
          "ensemblId": "ENSG00000170425",
          "biotype": "protein_coding",
          "start": 15945093,
          "end": 15976467,
          "strand": "+",
          "slug": "adora2b"
        },
        {
          "symbol": "ZSWIM7",
          "ensemblId": "ENSG00000214941",
          "biotype": "protein_coding",
          "start": 15976219,
          "end": 15999717,
          "strand": "-",
          "slug": "zswim7"
        },
        {
          "symbol": "TTC19",
          "ensemblId": "ENSG00000011295",
          "biotype": "protein_coding",
          "start": 15999386,
          "end": 16068416,
          "strand": "+",
          "slug": "ttc19"
        },
        {
          "symbol": "NCOR1",
          "ensemblId": "ENSG00000141027",
          "biotype": "protein_coding",
          "start": 16029065,
          "end": 16218185,
          "strand": "-",
          "slug": "ncor1"
        },
        {
          "symbol": "PIGL",
          "ensemblId": "ENSG00000108474",
          "biotype": "protein_coding",
          "start": 16217181,
          "end": 16351797,
          "strand": "+",
          "slug": "pigl"
        },
        {
          "symbol": "CENPV",
          "ensemblId": "ENSG00000166582",
          "biotype": "protein_coding",
          "start": 16340011,
          "end": 16353661,
          "strand": "-",
          "slug": "cenpv"
        },
        {
          "symbol": "TRPV2",
          "ensemblId": "ENSG00000187688",
          "biotype": "protein_coding",
          "start": 16407465,
          "end": 16437861,
          "strand": "+",
          "slug": "trpv2"
        },
        {
          "symbol": "LRRC75A",
          "ensemblId": "ENSG00000181350",
          "biotype": "protein_coding",
          "start": 16441493,
          "end": 16492237,
          "strand": "-",
          "slug": "lrrc75a"
        },
        {
          "symbol": "ZNF287",
          "ensemblId": "ENSG00000141040",
          "biotype": "protein_coding",
          "start": 16546954,
          "end": 16569218,
          "strand": "-",
          "slug": "znf287"
        },
        {
          "symbol": "ZNF624",
          "ensemblId": "ENSG00000197566",
          "biotype": "protein_coding",
          "start": 16620734,
          "end": 16653860,
          "strand": "-",
          "slug": "znf624"
        },
        {
          "symbol": "CCDC144A",
          "ensemblId": "ENSG00000170160",
          "biotype": "protein_coding",
          "start": 16689537,
          "end": 16777974,
          "strand": "+",
          "slug": "ccdc144a"
        },
        {
          "symbol": "",
          "ensemblId": "ENSG00000266302",
          "biotype": "protein_coding",
          "start": 16690261,
          "end": 16804453,
          "strand": "+"
        }
      ],
      "truncated": false
    },
    "reports": [],
    "pharmacogenomics": [],
    "traits": [],
    "phenotypes": [
      {
        "slug": "abnormal-oral-cavity-morphology",
        "name": "Abnormality of the oral cavity",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/abnormal-oral-cavity-morphology"
      },
      {
        "slug": "aspiration-pneumonia",
        "name": "Aspiration pneumonia",
        "systems": [
          "abnormality-of-the-immune-system",
          "abnormality-of-the-respiratory-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/aspiration-pneumonia"
      },
      {
        "slug": "bifid-uvula",
        "name": "Bifid uvula",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/bifid-uvula"
      },
      {
        "slug": "nasal-dysarthria",
        "name": "Breathy speech",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/nasal-dysarthria"
      },
      {
        "slug": "cleft-lip",
        "name": "Cleft lip",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/cleft-lip"
      },
      {
        "slug": "cleft-soft-palate",
        "name": "Cleft soft palate",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/cleft-soft-palate"
      },
      {
        "slug": "conductive-hearing-impairment",
        "name": "Conductive deafness",
        "systems": [
          "abnormality-of-the-ear"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/conductive-hearing-impairment"
      },
      {
        "slug": "hypoplasia-of-the-maxilla",
        "name": "Decreased size of maxilla",
        "systems": [
          "abnormality-of-head-or-neck",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/hypoplasia-of-the-maxilla"
      },
      {
        "slug": "feeding-difficulties-in-infancy",
        "name": "Feeding difficulties in infancy",
        "systems": [
          "abnormality-of-the-digestive-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/feeding-difficulties-in-infancy"
      },
      {
        "slug": "hearing-impairment",
        "name": "Hearing impairment",
        "systems": [
          "abnormality-of-the-ear"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/hearing-impairment"
      },
      {
        "slug": "language-impairment",
        "name": "Language impairment",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/language-impairment"
      },
      {
        "slug": "nasal-regurgitation",
        "name": "Nasal regurgitation",
        "systems": [
          "abnormality-of-the-digestive-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/nasal-regurgitation"
      },
      {
        "slug": "hypernasal-speech",
        "name": "Nasal speech",
        "systems": [
          "abnormality-of-the-voice"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/hypernasal-speech"
      },
      {
        "slug": "obstructive-sleep-apnea",
        "name": "Obstructive sleep apnea",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/obstructive-sleep-apnea"
      },
      {
        "slug": "oral-pharyngeal-dysphagia",
        "name": "Oral-pharyngeal dysphagia",
        "systems": [
          "abnormality-of-the-digestive-system",
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/oral-pharyngeal-dysphagia"
      },
      {
        "slug": "poor-suck",
        "name": "Poor suck",
        "systems": [
          "abnormality-of-the-digestive-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/poor-suck"
      },
      {
        "slug": "receptive-language-delay",
        "name": "Receptive language delay",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/receptive-language-delay"
      },
      {
        "slug": "recurrent-otitis-media",
        "name": "Recurrent middle ear infection",
        "systems": [
          "abnormality-of-the-ear",
          "abnormality-of-the-immune-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/recurrent-otitis-media"
      },
      {
        "slug": "short-face",
        "name": "Short face",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/short-face"
      },
      {
        "slug": "speech-articulation-difficulties",
        "name": "Speech articulation difficulties",
        "systems": [
          "abnormality-of-the-nervous-system",
          "abnormality-of-the-voice"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/speech-articulation-difficulties"
      },
      {
        "slug": "submucous-cleft-palate",
        "name": "Submucous cleft palate",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/submucous-cleft-palate"
      },
      {
        "slug": "submucous-cleft-soft-palate",
        "name": "Submucous cleft soft palate",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/submucous-cleft-soft-palate"
      },
      {
        "slug": "velopharyngeal-insufficiency",
        "name": "Velopharyngeal incompetence",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/velopharyngeal-insufficiency"
      }
    ],
    "related": [],
    "sources": null,
    "locusKind": "proteinCoding"
  },
  "variants": {
    "total": 0,
    "url": null,
    "items": []
  }
}