{
  "url": "https://dantelabs.com/pt/genes/syne4",
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    "symbol": "SYNE4",
    "name": "spectrin repeat containing nuclear envelope family member 4",
    "hgnc": "HGNC:26703",
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    "locusType": "gene with protein product",
    "aliases": [
      "FLJ36445",
      "Nesprin-4",
      "Nesp4"
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      "C19orf46",
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    ],
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    "entrezId": 163183,
    "omim": [
      "615535"
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      "Q8N205"
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      ],
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        {
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        {
          "symbol": "KIRREL2",
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        {
          "symbol": "APLP1",
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        {
          "symbol": "NFKBID",
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        {
          "symbol": "HCST",
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          "symbol": "TYROBP",
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        {
          "symbol": "LRFN3",
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        {
          "symbol": "SDHAF1",
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        {
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        {
          "symbol": "OVOL3",
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        {
          "symbol": "POLR2I",
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        {
          "symbol": "TBCB",
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          "biotype": "protein_coding",
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        },
        {
          "symbol": "CAPNS1",
          "ensemblId": "ENSG00000126247",
          "biotype": "protein_coding",
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        {
          "symbol": "COX7A1",
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        },
        {
          "symbol": "ZNF565",
          "ensemblId": "ENSG00000196357",
          "biotype": "protein_coding",
          "start": 36181542,
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          "strand": "-",
          "slug": "znf565"
        },
        {
          "symbol": "ZNF146",
          "ensemblId": "ENSG00000167635",
          "biotype": "protein_coding",
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        },
        {
          "symbol": "ZFP14",
          "ensemblId": "ENSG00000142065",
          "biotype": "protein_coding",
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        },
        {
          "symbol": "ZFP82",
          "ensemblId": "ENSG00000181007",
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          "slug": "zfp82"
        },
        {
          "symbol": "ZNF566",
          "ensemblId": "ENSG00000186017",
          "biotype": "protein_coding",
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        }
      ],
      "truncated": false
    },
    "reports": [
      {
        "slug": "hearing-loss-and-deafness",
        "name": "Perda Auditiva e Surdez",
        "diseases": [
          {
            "mondoId": "MONDO:0019497",
            "name": "Perda Auditiva Genética Não Sindrómica",
            "genes": 97,
            "inheritance": null,
            "description": "Perda auditiva hereditária sem outras manifestações clínicas, incluindo as formas recessivas mais comuns causadas por GJB2, OTOF, SLC26A4, STRC e muitos outros genes, bem como as formas dominantes, ligadas ao cromossoma X e mitocondriais.",
            "management": "Conhecer a causa genética pode orientar o apoio auditivo e as decisões sobre implante coclear, a elegibilidade para ensaios de terapia genética (por exemplo, OTOF) e o aconselhamento familiar.",
            "evidence": {
              "gencc": [
                "Labcorp Genetics (formerly Invitae)",
                "PanelApp Australia"
              ],
              "clingen": "Moderate",
              "acmgSf": false,
              "inheritance": [
                "autosomal-recessive"
              ]
            },
            "sameAsReport": false,
            "broad": true
          }
        ],
        "url": "https://dantelabs.com/pt/conditions/hearing-loss-and-deafness"
      }
    ],
    "pharmacogenomics": [],
    "traits": [],
    "phenotypes": [
      {
        "slug": "progressive-sensorineural-hearing-impairment",
        "name": "Progressive sensorineural hearing impairment",
        "systems": [
          "abnormality-of-the-ear"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/progressive-sensorineural-hearing-impairment"
      }
    ],
    "related": [
      {
        "slug": "actg1",
        "symbol": "ACTG1",
        "name": "actin gamma 1",
        "shared": 1,
        "url": "https://dantelabs.com/pt/genes/actg1"
      },
      {
        "slug": "afg2b",
        "symbol": "AFG2B",
        "name": "AAA ATPase AFG2B",
        "shared": 1,
        "url": "https://dantelabs.com/pt/genes/afg2b"
      },
      {
        "slug": "aifm1",
        "symbol": "AIFM1",
        "name": "apoptosis inducing factor mitochondria associated 1",
        "shared": 1,
        "url": "https://dantelabs.com/pt/genes/aifm1"
      },
      {
        "slug": "atp11a",
        "symbol": "ATP11A",
        "name": "ATPase phospholipid transporting 11A",
        "shared": 1,
        "url": "https://dantelabs.com/pt/genes/atp11a"
      },
      {
        "slug": "atp2b2",
        "symbol": "ATP2B2",
        "name": "ATPase plasma membrane Ca2+ transporting 2",
        "shared": 1,
        "url": "https://dantelabs.com/pt/genes/atp2b2"
      },
      {
        "slug": "cabp2",
        "symbol": "CABP2",
        "name": "calcium binding protein 2",
        "shared": 1,
        "url": "https://dantelabs.com/pt/genes/cabp2"
      },
      {
        "slug": "cd164",
        "symbol": "CD164",
        "name": "CD164 molecule",
        "shared": 1,
        "url": "https://dantelabs.com/pt/genes/cd164"
      },
      {
        "slug": "cdc14a",
        "symbol": "CDC14A",
        "name": "cell division cycle 14A",
        "shared": 1,
        "url": "https://dantelabs.com/pt/genes/cdc14a"
      },
      {
        "slug": "cdh23",
        "symbol": "CDH23",
        "name": "cadherin related 23",
        "shared": 1,
        "url": "https://dantelabs.com/pt/genes/cdh23"
      },
      {
        "slug": "ceacam16",
        "symbol": "CEACAM16",
        "name": "CEA cell adhesion molecule 16, tectorial membrane component",
        "shared": 1,
        "url": "https://dantelabs.com/pt/genes/ceacam16"
      },
      {
        "slug": "cib2",
        "symbol": "CIB2",
        "name": "calcium and integrin binding family member 2",
        "shared": 1,
        "url": "https://dantelabs.com/pt/genes/cib2"
      },
      {
        "slug": "cldn14",
        "symbol": "CLDN14",
        "name": "claudin 14",
        "shared": 1,
        "url": "https://dantelabs.com/pt/genes/cldn14"
      }
    ],
    "sources": {
      "bundleId": "2026.10.16-c6eea6bf",
      "panel": "2026-10-16",
      "acmgSf": "SF v3.2"
    },
    "locusKind": "proteinCoding"
  },
  "variants": {
    "total": 0,
    "url": null,
    "items": []
  }
}