{
  "url": "https://dantelabs.com/pt/genes/smoc2",
  "gene": {
    "slug": "smoc2",
    "symbol": "SMOC2",
    "name": "SPARC related modular calcium binding 2",
    "hgnc": "HGNC:20323",
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    "location": "6q27",
    "locusType": "gene with protein product",
    "aliases": [
      "SMAP2"
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    "previousSymbols": [],
    "ensemblId": "ENSG00000112562",
    "entrezId": 64094,
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    "uniprot": [
      "Q9H3U7"
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      "release": "v1.5",
      "chrom": "6",
      "start": 168441184,
      "end": 168667992,
      "strand": "+",
      "ensemblTranscript": "ENST00000356284.7",
      "refseqTranscript": "NM_001166412.2",
      "ensemblProtein": "ENSP00000348630.3",
      "refseqProtein": "NP_001159884.1",
      "exons": [
        {
          "start": 168441184,
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        },
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        }
      ],
      "cds": {
        "start": 168441371,
        "end": 168666438
      }
    },
    "grch37": {
      "build": "GRCh37",
      "release": "87",
      "chrom": "6",
      "start": 168841831,
      "end": 169073984,
      "strand": "+"
    },
    "neighbourhood": {
      "release": "116",
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      "end": 169054587,
      "genes": [
        {
          "symbol": "FRMD1",
          "ensemblId": "ENSG00000153303",
          "biotype": "protein_coding",
          "start": 168053095,
          "end": 168101511,
          "strand": "-",
          "slug": "frmd1"
        },
        {
          "symbol": "DACT2",
          "ensemblId": "ENSG00000164488",
          "biotype": "protein_coding",
          "start": 168292830,
          "end": 168319783,
          "strand": "-",
          "slug": "dact2"
        }
      ],
      "truncated": false
    },
    "reports": [
      {
        "slug": "dentinogenesis-imperfecta",
        "name": "Dentinogénese Imperfeita",
        "diseases": [
          {
            "mondoId": "MONDO:0015613",
            "name": "Displasia da Dentina",
            "genes": 1,
            "inheritance": null,
            "description": "Defeitos hereditários da dentina que causam raízes curtas ou malformadas, câmaras pulpares anormais e perda precoce de dentes; o tipo II é causado por variantes em DSPP, no mesmo espetro da dentinogénese imperfeita.",
            "management": "Conhecer esta informação pode apoiar a vigilância dentária precoce e o planeamento para proteger os dentes afetados.",
            "evidence": {
              "gencc": [
                "G2P",
                "Labcorp Genetics (formerly Invitae)",
                "PanelApp Australia"
              ],
              "acmgSf": false,
              "inheritance": [
                "autosomal-recessive"
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            },
            "sameAsReport": false,
            "broad": false
          }
        ],
        "url": "https://dantelabs.com/pt/conditions/dentinogenesis-imperfecta"
      }
    ],
    "pharmacogenomics": [],
    "traits": [],
    "phenotypes": [
      {
        "slug": "periapical-bone-loss",
        "name": "Bone loss around tooth root",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "url": "https://dantelabs.com/traits/periapical-bone-loss"
      },
      {
        "slug": "short-dental-root",
        "name": "Decreased length of dental roots",
        "systems": [
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        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/short-dental-root"
      },
      {
        "slug": "microdontia",
        "name": "Decreased size of tooth",
        "systems": [
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        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/microdontia"
      },
      {
        "slug": "oligodontia",
        "name": "Failure of development of more than six teeth",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/oligodontia"
      },
      {
        "slug": "pulp-obliteration",
        "name": "Pulp obliteration",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "url": "https://dantelabs.com/traits/pulp-obliteration"
      },
      {
        "slug": "taurodontia",
        "name": "Taurodontia",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/taurodontia"
      },
      {
        "slug": "enamel-hypoplasia",
        "name": "Thin dental enamel",
        "systems": [
          "abnormality-of-head-or-neck",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/enamel-hypoplasia"
      }
    ],
    "related": [],
    "sources": {
      "bundleId": "2026.10.17-8666dff2",
      "panel": "2026-10-17",
      "acmgSf": "SF v3.2"
    },
    "locusKind": "proteinCoding"
  },
  "variants": {
    "total": 0,
    "url": null,
    "items": []
  }
}