{
  "url": "https://dantelabs.com/pt/genes/slc2a9",
  "gene": {
    "slug": "slc2a9",
    "symbol": "SLC2A9",
    "name": "solute carrier family 2 member 9",
    "hgnc": "HGNC:13446",
    "summary": null,
    "location": "4p16.1",
    "locusType": "gene with protein product",
    "aliases": [
      "Glut9",
      "GLUTX",
      "URATv1"
    ],
    "previousSymbols": [],
    "ensemblId": "ENSG00000109667",
    "entrezId": 56606,
    "omim": [
      "606142"
    ],
    "uniprot": [
      "Q9NRM0"
    ],
    "model": {
      "build": "GRCh38",
      "release": "v1.5",
      "chrom": "4",
      "start": 9826224,
      "end": 10021497,
      "strand": "-",
      "ensemblTranscript": "ENST00000264784.8",
      "refseqTranscript": "NM_020041.3",
      "ensemblProtein": "ENSP00000264784.3",
      "refseqProtein": "NP_064425.2",
      "exons": [
        {
          "start": 9826224,
          "end": 9826600
        },
        {
          "start": 9834881,
          "end": 9835008
        },
        {
          "start": 9887567,
          "end": 9887642
        },
        {
          "start": 9890610,
          "end": 9890711
        },
        {
          "start": 9908235,
          "end": 9908345
        },
        {
          "start": 9920385,
          "end": 9920572
        },
        {
          "start": 9941913,
          "end": 9942045
        },
        {
          "start": 9980592,
          "end": 9980737
        },
        {
          "start": 9985669,
          "end": 9985793
        },
        {
          "start": 9996781,
          "end": 9996941
        },
        {
          "start": 10018975,
          "end": 10019073
        },
        {
          "start": 10021280,
          "end": 10021497
        }
      ],
      "cds": {
        "start": 9826397,
        "end": 10021429
      }
    },
    "grch37": {
      "build": "GRCh37",
      "release": "87",
      "chrom": "4",
      "start": 9772777,
      "end": 10056560,
      "strand": "-"
    },
    "neighbourhood": {
      "release": "116",
      "start": 9423861,
      "end": 10423860,
      "genes": [
        {
          "symbol": "DEFB131A",
          "ensemblId": "ENSG00000186146",
          "biotype": "protein_coding",
          "start": 9444413,
          "end": 9450672,
          "strand": "+",
          "slug": "defb131a"
        },
        {
          "symbol": "DRD5",
          "ensemblId": "ENSG00000169676",
          "biotype": "protein_coding",
          "start": 9781387,
          "end": 9784012,
          "strand": "+",
          "slug": "drd5"
        },
        {
          "symbol": "WDR1",
          "ensemblId": "ENSG00000071127",
          "biotype": "protein_coding",
          "start": 10068089,
          "end": 10116988,
          "strand": "-",
          "slug": "wdr1"
        }
      ],
      "truncated": false
    },
    "reports": [
      {
        "slug": "renal-hypouricemia",
        "name": "Hipouricemia Renal",
        "diseases": [
          {
            "mondoId": "MONDO:0009071",
            "name": "Hipouricemia Renal Hereditária",
            "genes": 2,
            "inheritance": "autosomal-recessive",
            "description": "Uma perturbação recessiva da reabsorção do ácido úrico causada por variantes em SLC22A12 ou SLC2A9, associada a lesão renal aguda induzida pelo exercício e a cálculos de ácido úrico.",
            "management": "Conhecer esta condição ajuda a manter uma boa hidratação e a evitar exercício anaeróbico extremo, reduzindo o risco de lesão renal.",
            "evidence": {
              "gencc": [
                "Labcorp Genetics (formerly Invitae)",
                "PanelApp Australia"
              ],
              "acmgSf": false,
              "inheritance": [
                "autosomal-recessive"
              ]
            },
            "sameAsReport": false,
            "broad": false
          }
        ],
        "url": "https://dantelabs.com/pt/conditions/renal-hypouricemia"
      }
    ],
    "pharmacogenomics": [],
    "traits": [],
    "phenotypes": [
      {
        "slug": "abnormal-renal-physiology",
        "name": "Abnormal kidney function",
        "systems": [
          "abnormality-of-the-genitourinary-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/abnormal-renal-physiology"
      },
      {
        "slug": "abnormal-renal-tubule-morphology",
        "name": "Abnormal renal tubule morphology",
        "systems": [
          "abnormality-of-the-genitourinary-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/abnormal-renal-tubule-morphology"
      },
      {
        "slug": "acute-kidney-injury",
        "name": "Acute kidney injury",
        "systems": [
          "abnormality-of-the-genitourinary-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/acute-kidney-injury"
      },
      {
        "slug": "back-pain",
        "name": "Back pain",
        "systems": [
          "abnormality-of-the-musculoskeletal-system",
          "constitutional-symptom"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/back-pain"
      },
      {
        "slug": "hematuria",
        "name": "Blood in urine",
        "systems": [
          "abnormality-of-metabolism-homeostasis",
          "abnormality-of-the-genitourinary-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/hematuria"
      },
      {
        "slug": "chronic-kidney-disease",
        "name": "Chronic kidney disease",
        "systems": [
          "abnormality-of-the-genitourinary-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/chronic-kidney-disease"
      },
      {
        "slug": "decreased-glomerular-filtration-rate",
        "name": "Decreased glomerular filtration rate",
        "systems": [
          "abnormality-of-the-genitourinary-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/decreased-glomerular-filtration-rate"
      },
      {
        "slug": "hypercalciuria",
        "name": "Elevated urine calcium levels",
        "systems": [
          "abnormality-of-metabolism-homeostasis",
          "abnormality-of-the-genitourinary-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/hypercalciuria"
      },
      {
        "slug": "hyperuricosuria",
        "name": "High urine uric acid level",
        "systems": [
          "abnormality-of-metabolism-homeostasis",
          "abnormality-of-the-genitourinary-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/hyperuricosuria"
      },
      {
        "slug": "increased-blood-urea-nitrogen",
        "name": "Increased blood urea nitrogen",
        "systems": [
          "abnormality-of-metabolism-homeostasis"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/increased-blood-urea-nitrogen"
      },
      {
        "slug": "kidney-stone",
        "name": "Kidney stone",
        "systems": [
          "abnormality-of-the-genitourinary-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/kidney-stone"
      },
      {
        "slug": "hypouricemia",
        "name": "Low blood uric acid levels",
        "systems": [
          "abnormality-of-metabolism-homeostasis"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/hypouricemia"
      },
      {
        "slug": "mild-proteinuria",
        "name": "Mild proteinuria",
        "systems": [
          "abnormality-of-metabolism-homeostasis",
          "abnormality-of-the-genitourinary-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/mild-proteinuria"
      },
      {
        "slug": "nausea",
        "name": "Nausea",
        "systems": [
          "abnormality-of-the-digestive-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/nausea"
      },
      {
        "slug": "postexertional-symptom-exacerbation",
        "name": "Postexertional symptom exacerbation",
        "systems": [
          "constitutional-symptom"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/postexertional-symptom-exacerbation"
      },
      {
        "slug": "uric-acid-urolithiasis-independent-of-gout",
        "name": "Uric acid urolithiasis independent of gout",
        "systems": [
          "abnormality-of-the-genitourinary-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/uric-acid-urolithiasis-independent-of-gout"
      },
      {
        "slug": "vomiting",
        "name": "Vomiting",
        "systems": [
          "abnormality-of-the-digestive-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/vomiting"
      }
    ],
    "related": [
      {
        "slug": "slc22a12",
        "symbol": "SLC22A12",
        "name": "solute carrier family 22 member 12",
        "shared": 1,
        "url": "https://dantelabs.com/pt/genes/slc22a12"
      }
    ],
    "sources": {
      "bundleId": "2026.10.17-8666dff2",
      "panel": "2026-10-17",
      "acmgSf": "SF v3.2"
    },
    "locusKind": "proteinCoding"
  },
  "variants": {
    "total": 0,
    "url": null,
    "items": []
  }
}