{
  "url": "https://dantelabs.com/pt/genes/myh8",
  "gene": {
    "slug": "myh8",
    "symbol": "MYH8",
    "name": "myosin heavy chain 8",
    "hgnc": "HGNC:7578",
    "summary": null,
    "location": "17p13.1",
    "locusType": "gene with protein product",
    "aliases": [
      "MyHC-peri",
      "MyHC-pn"
    ],
    "previousSymbols": [],
    "ensemblId": "ENSG00000133020",
    "entrezId": 4626,
    "omim": [
      "160741"
    ],
    "uniprot": [
      "P13535"
    ],
    "model": {
      "build": "GRCh38",
      "release": "v1.5",
      "chrom": "17",
      "start": 10390322,
      "end": 10421950,
      "strand": "-",
      "ensemblTranscript": "ENST00000403437.2",
      "refseqTranscript": "NM_002472.3",
      "ensemblProtein": "ENSP00000384330.2",
      "refseqProtein": "NP_002463.2",
      "exons": [
        {
          "start": 10390322,
          "end": 10390603
        },
        {
          "start": 10391882,
          "end": 10391977
        },
        {
          "start": 10392542,
          "end": 10392646
        },
        {
          "start": 10392831,
          "end": 10393001
        },
        {
          "start": 10393085,
          "end": 10393210
        },
        {
          "start": 10394249,
          "end": 10394452
        },
        {
          "start": 10395133,
          "end": 10395441
        },
        {
          "start": 10396330,
          "end": 10396454
        },
        {
          "start": 10396553,
          "end": 10396718
        },
        {
          "start": 10396803,
          "end": 10396986
        },
        {
          "start": 10398444,
          "end": 10398640
        },
        {
          "start": 10398768,
          "end": 10398886
        },
        {
          "start": 10399543,
          "end": 10399669
        },
        {
          "start": 10400390,
          "end": 10400779
        },
        {
          "start": 10400869,
          "end": 10400959
        },
        {
          "start": 10401046,
          "end": 10401191
        },
        {
          "start": 10401275,
          "end": 10401451
        },
        {
          "start": 10401543,
          "end": 10401785
        },
        {
          "start": 10404330,
          "end": 10404585
        },
        {
          "start": 10406041,
          "end": 10406177
        },
        {
          "start": 10406274,
          "end": 10406397
        },
        {
          "start": 10406690,
          "end": 10406807
        },
        {
          "start": 10406892,
          "end": 10406979
        },
        {
          "start": 10409097,
          "end": 10409164
        },
        {
          "start": 10409279,
          "end": 10409588
        },
        {
          "start": 10410777,
          "end": 10410947
        },
        {
          "start": 10412370,
          "end": 10412519
        },
        {
          "start": 10412610,
          "end": 10412728
        },
        {
          "start": 10413902,
          "end": 10414040
        },
        {
          "start": 10414192,
          "end": 10414295
        },
        {
          "start": 10414386,
          "end": 10414484
        },
        {
          "start": 10415116,
          "end": 10415179
        },
        {
          "start": 10415292,
          "end": 10415384
        },
        {
          "start": 10415472,
          "end": 10415580
        },
        {
          "start": 10415681,
          "end": 10415708
        },
        {
          "start": 10418645,
          "end": 10418801
        },
        {
          "start": 10418887,
          "end": 10419030
        },
        {
          "start": 10420018,
          "end": 10420257
        },
        {
          "start": 10421663,
          "end": 10421706
        },
        {
          "start": 10421930,
          "end": 10421950
        }
      ],
      "cds": {
        "start": 10390454,
        "end": 10420227
      }
    },
    "grch37": {
      "build": "GRCh37",
      "release": "87",
      "chrom": "17",
      "start": 10293639,
      "end": 10325267,
      "strand": "-"
    },
    "neighbourhood": {
      "release": "116",
      "start": 9906136,
      "end": 10906135,
      "genes": [
        {
          "symbol": "GAS7",
          "ensemblId": "ENSG00000007237",
          "biotype": "protein_coding",
          "start": 9910606,
          "end": 10198912,
          "strand": "-",
          "slug": "gas7"
        },
        {
          "symbol": "MYH13",
          "ensemblId": "ENSG00000006788",
          "biotype": "protein_coding",
          "start": 10300865,
          "end": 10373130,
          "strand": "-",
          "slug": "myh13"
        },
        {
          "symbol": "MYH4",
          "ensemblId": "ENSG00000264424",
          "biotype": "protein_coding",
          "start": 10443290,
          "end": 10469559,
          "strand": "-",
          "slug": "myh4"
        },
        {
          "symbol": "MYH1",
          "ensemblId": "ENSG00000109061",
          "biotype": "protein_coding",
          "start": 10491027,
          "end": 10518719,
          "strand": "-",
          "slug": "myh1"
        },
        {
          "symbol": "MYH2",
          "ensemblId": "ENSG00000125414",
          "biotype": "protein_coding",
          "start": 10521147,
          "end": 10549700,
          "strand": "-",
          "slug": "myh2"
        },
        {
          "symbol": "MYH3",
          "ensemblId": "ENSG00000109063",
          "biotype": "protein_coding",
          "start": 10628526,
          "end": 10657309,
          "strand": "-",
          "slug": "myh3"
        },
        {
          "symbol": "SCO1",
          "ensemblId": "ENSG00000133028",
          "biotype": "protein_coding",
          "start": 10672474,
          "end": 10698375,
          "strand": "-",
          "slug": "sco1"
        },
        {
          "symbol": "ADPRM",
          "ensemblId": "ENSG00000170222",
          "biotype": "protein_coding",
          "start": 10697247,
          "end": 10713286,
          "strand": "+",
          "slug": "adprm"
        },
        {
          "symbol": "TMEM220",
          "ensemblId": "ENSG00000187824",
          "biotype": "protein_coding",
          "start": 10699015,
          "end": 10730380,
          "strand": "-",
          "slug": "tmem220"
        },
        {
          "symbol": "TMEM238L",
          "ensemblId": "ENSG00000263429",
          "biotype": "protein_coding",
          "start": 10794908,
          "end": 10804104,
          "strand": "-",
          "slug": "tmem238l"
        },
        {
          "symbol": "PIRT",
          "ensemblId": "ENSG00000233670",
          "biotype": "protein_coding",
          "start": 10822470,
          "end": 10838106,
          "strand": "-",
          "slug": "pirt"
        }
      ],
      "truncated": false
    },
    "reports": [],
    "pharmacogenomics": [],
    "traits": [],
    "phenotypes": [
      {
        "slug": "arthrogryposis-multiplex-congenita",
        "name": "Arthrogryposis multiplex congenita",
        "systems": [
          "abnormality-of-the-musculoskeletal-system"
        ],
        "url": "https://dantelabs.com/traits/arthrogryposis-multiplex-congenita"
      },
      {
        "slug": "macrocephaly",
        "name": "Big calvaria",
        "systems": [
          "abnormality-of-head-or-neck",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/macrocephaly"
      },
      {
        "slug": "mandibular-prognathia",
        "name": "Big lower jaw",
        "systems": [
          "abnormality-of-head-or-neck",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/mandibular-prognathia"
      },
      {
        "slug": "cardiac-myxoma",
        "name": "Cardiac myxoma",
        "systems": [
          "abnormality-of-the-cardiovascular-system",
          "neoplasm"
        ],
        "url": "https://dantelabs.com/traits/cardiac-myxoma"
      },
      {
        "slug": "talipes-equinovarus",
        "name": "Club feet",
        "systems": [
          "abnormality-of-limbs"
        ],
        "url": "https://dantelabs.com/traits/talipes-equinovarus"
      },
      {
        "slug": "trismus",
        "name": "Decrease in jaw mobility",
        "systems": [
          "abnormality-of-head-or-neck",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/trismus"
      },
      {
        "slug": "deep-philtrum",
        "name": "Deep philtrum",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/deep-philtrum"
      },
      {
        "slug": "distal-arthrogryposis",
        "name": "Distal arthrogryposis",
        "systems": [
          "abnormality-of-the-musculoskeletal-system"
        ],
        "url": "https://dantelabs.com/traits/distal-arthrogryposis"
      },
      {
        "slug": "ptosis",
        "name": "Drooping upper eyelid",
        "systems": [
          "abnormality-of-the-eye"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/ptosis"
      },
      {
        "slug": "facial-asymmetry",
        "name": "Facial asymmetry",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "url": "https://dantelabs.com/traits/facial-asymmetry"
      },
      {
        "slug": "feeding-difficulties",
        "name": "Feeding difficulties",
        "systems": [
          "abnormality-of-the-digestive-system"
        ],
        "url": "https://dantelabs.com/traits/feeding-difficulties"
      },
      {
        "slug": "metatarsus-adductus",
        "name": "Front half of foot turns inward",
        "systems": [
          "abnormality-of-limbs",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "url": "https://dantelabs.com/traits/metatarsus-adductus"
      },
      {
        "slug": "finger-symphalangism",
        "name": "Fused finger bones",
        "systems": [
          "abnormality-of-limbs",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/finger-symphalangism"
      },
      {
        "slug": "hammertoe",
        "name": "Hammertoe",
        "systems": [
          "abnormality-of-limbs",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "url": "https://dantelabs.com/traits/hammertoe"
      },
      {
        "slug": "hip-dislocation",
        "name": "Hip dislocation",
        "systems": [
          "abnormality-of-limbs",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/hip-dislocation"
      },
      {
        "slug": "limitation-of-joint-mobility",
        "name": "Limitation of joint mobility",
        "systems": [
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/limitation-of-joint-mobility"
      },
      {
        "slug": "micrognathia",
        "name": "Little lower jaw",
        "systems": [
          "abnormality-of-head-or-neck",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "url": "https://dantelabs.com/traits/micrognathia"
      },
      {
        "slug": "abnormality-of-the-musculature",
        "name": "Muscular abnormality",
        "systems": [
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/abnormality-of-the-musculature"
      },
      {
        "slug": "dysphagia",
        "name": "Poor swallowing",
        "systems": [
          "abnormality-of-the-digestive-system",
          "abnormality-of-the-nervous-system"
        ],
        "url": "https://dantelabs.com/traits/dysphagia"
      },
      {
        "slug": "short-stature",
        "name": "Short stature",
        "systems": [
          "growth-abnormality"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/short-stature"
      },
      {
        "slug": "tall-chin",
        "name": "Tall chin",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/tall-chin"
      },
      {
        "slug": "cutaneous-syndactyly-of-toes",
        "name": "Webbed skin of toes",
        "systems": [
          "abnormality-of-limbs",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "url": "https://dantelabs.com/traits/cutaneous-syndactyly-of-toes"
      }
    ],
    "related": [],
    "sources": null,
    "locusKind": "proteinCoding"
  },
  "variants": {
    "total": 0,
    "url": null,
    "items": []
  }
}