{
  "url": "https://dantelabs.com/pt/genes/lhx1",
  "gene": {
    "slug": "lhx1",
    "symbol": "LHX1",
    "name": "LIM homeobox 1",
    "hgnc": "HGNC:6593",
    "summary": null,
    "location": "17q12",
    "locusType": "gene with protein product",
    "aliases": [
      "LIM-1",
      "LIM1"
    ],
    "previousSymbols": [],
    "ensemblId": "ENSG00000273706",
    "entrezId": 3975,
    "omim": [
      "601999"
    ],
    "uniprot": [
      "P48742"
    ],
    "model": {
      "build": "GRCh38",
      "release": "v1.5",
      "chrom": "17",
      "start": 36937475,
      "end": 36944612,
      "strand": "+",
      "ensemblTranscript": "ENST00000614239.1",
      "refseqTranscript": "NM_005568.5",
      "ensemblProtein": "ENSP00000477829.1",
      "refseqProtein": "NP_005559.2",
      "exons": [
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          "start": 36937475,
          "end": 36938367
        },
        {
          "start": 36940290,
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        },
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          "start": 36940610,
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          "end": 36942365
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        {
          "start": 36942752,
          "end": 36944612
        }
      ],
      "cds": {
        "start": 36938198,
        "end": 36943131
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    },
    "grch37": {
      "build": "GRCh37",
      "release": "87",
      "chrom": "17",
      "start": 35294084,
      "end": 35301917,
      "strand": "+"
    },
    "neighbourhood": {
      "release": "116",
      "start": 36441044,
      "end": 37441043,
      "genes": [
        {
          "symbol": "ZNHIT3",
          "ensemblId": "ENSG00000273611",
          "biotype": "protein_coding",
          "start": 36486629,
          "end": 36499310,
          "strand": "+",
          "slug": "znhit3"
        },
        {
          "symbol": "MYO19",
          "ensemblId": "ENSG00000278259",
          "biotype": "protein_coding",
          "start": 36495118,
          "end": 36545889,
          "strand": "-",
          "slug": "myo19"
        },
        {
          "symbol": "PIGW",
          "ensemblId": "ENSG00000277161",
          "biotype": "protein_coding",
          "start": 36534981,
          "end": 36542354,
          "strand": "+",
          "slug": "pigw"
        },
        {
          "symbol": "GGNBP2",
          "ensemblId": "ENSG00000278311",
          "biotype": "protein_coding",
          "start": 36544888,
          "end": 36589866,
          "strand": "+",
          "slug": "ggnbp2"
        },
        {
          "symbol": "DHRS11",
          "ensemblId": "ENSG00000278535",
          "biotype": "protein_coding",
          "start": 36591782,
          "end": 36600809,
          "strand": "+",
          "slug": "dhrs11"
        },
        {
          "symbol": "MRM1",
          "ensemblId": "ENSG00000278619",
          "biotype": "protein_coding",
          "start": 36601571,
          "end": 36621636,
          "strand": "+",
          "slug": "mrm1"
        },
        {
          "symbol": "AATF",
          "ensemblId": "ENSG00000275700",
          "biotype": "protein_coding",
          "start": 36948925,
          "end": 37056874,
          "strand": "+",
          "slug": "aatf"
        },
        {
          "symbol": "ACACA",
          "ensemblId": "ENSG00000278540",
          "biotype": "protein_coding",
          "start": 37084992,
          "end": 37406853,
          "strand": "-",
          "slug": "acaca"
        },
        {
          "symbol": "C17orf78",
          "ensemblId": "ENSG00000278505",
          "biotype": "protein_coding",
          "start": 37375985,
          "end": 37392708,
          "strand": "+",
          "slug": "c17orf78"
        },
        {
          "symbol": "TADA2A",
          "ensemblId": "ENSG00000276234",
          "biotype": "protein_coding",
          "start": 37406731,
          "end": 37479807,
          "strand": "+",
          "slug": "tada2a"
        }
      ],
      "truncated": false
    },
    "reports": [],
    "pharmacogenomics": [],
    "traits": [],
    "phenotypes": [
      {
        "slug": "pancreatic-aplasia",
        "name": "Absent pancreas",
        "systems": [
          "abnormality-of-the-digestive-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/pancreatic-aplasia"
      },
      {
        "slug": "renal-hypoplasia-aplasia",
        "name": "Absent/small kidney",
        "systems": [
          "abnormality-of-the-genitourinary-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/renal-hypoplasia-aplasia"
      },
      {
        "slug": "autism",
        "name": "Autism",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/autism"
      },
      {
        "slug": "cerebral-atrophy",
        "name": "Degeneration of cerebrum",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/cerebral-atrophy"
      },
      {
        "slug": "diabetes-mellitus",
        "name": "Diabetes mellitus",
        "systems": [
          "abnormality-of-metabolism-homeostasis",
          "abnormality-of-the-endocrine-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/diabetes-mellitus"
      },
      {
        "slug": "seizure",
        "name": "Epilepsy",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/seizure"
      },
      {
        "slug": "feeding-difficulties",
        "name": "Feeding difficulties",
        "systems": [
          "abnormality-of-the-digestive-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/feeding-difficulties"
      },
      {
        "slug": "global-developmental-delay",
        "name": "Global developmental delay",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/global-developmental-delay"
      },
      {
        "slug": "hearing-impairment",
        "name": "Hearing impairment",
        "systems": [
          "abnormality-of-the-ear"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/hearing-impairment"
      },
      {
        "slug": "elevated-circulating-hepatic-transaminase-concentration",
        "name": "High liver enzymes",
        "systems": [
          "abnormality-of-metabolism-homeostasis"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/elevated-circulating-hepatic-transaminase-concentration"
      },
      {
        "slug": "intellectual-disability",
        "name": "Intellectual disability",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/intellectual-disability"
      },
      {
        "slug": "language-impairment",
        "name": "Language impairment",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/language-impairment"
      },
      {
        "slug": "oligohydramnios",
        "name": "Low levels of amniotic fluid",
        "systems": [
          "abnormality-of-prenatal-development-or-birth"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/oligohydramnios"
      },
      {
        "slug": "multicystic-kidney-dysplasia",
        "name": "Multicystic kidney dysplasia",
        "systems": [
          "abnormality-of-the-genitourinary-system"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/multicystic-kidney-dysplasia"
      },
      {
        "slug": "renal-insufficiency",
        "name": "Renal failure",
        "systems": [
          "abnormality-of-the-genitourinary-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/renal-insufficiency"
      },
      {
        "slug": "shawl-scrotum",
        "name": "Scrotum surrounds penis",
        "systems": [
          "abnormality-of-the-genitourinary-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/shawl-scrotum"
      },
      {
        "slug": "short-stature",
        "name": "Short stature",
        "systems": [
          "growth-abnormality"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/short-stature"
      },
      {
        "slug": "subcortical-cerebral-atrophy",
        "name": "Subcortical cerebral atrophy",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/subcortical-cerebral-atrophy"
      },
      {
        "slug": "cryptorchidism",
        "name": "Undescended testes",
        "systems": [
          "abnormality-of-the-genitourinary-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/cryptorchidism"
      },
      {
        "slug": "ureterocele",
        "name": "Ureterocele",
        "systems": [
          "abnormality-of-the-genitourinary-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/ureterocele"
      },
      {
        "slug": "large-fontanelles",
        "name": "Wide fontanelles",
        "systems": [
          "abnormality-of-head-or-neck",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/large-fontanelles"
      }
    ],
    "related": [],
    "sources": null,
    "locusKind": "proteinCoding"
  },
  "variants": {
    "total": 0,
    "url": null,
    "items": []
  }
}