{
  "url": "https://dantelabs.com/pt/genes/defa1",
  "gene": {
    "slug": "defa1",
    "symbol": "DEFA1",
    "name": "defensin alpha 1",
    "hgnc": "HGNC:2761",
    "summary": null,
    "location": "8p23.1",
    "locusType": "gene with protein product",
    "aliases": [
      "HNP-1"
    ],
    "previousSymbols": [
      "DEF1",
      "MRS",
      "DEFA2"
    ],
    "ensemblId": "ENSG00000206047",
    "entrezId": 1667,
    "omim": [
      "125220"
    ],
    "uniprot": [
      "P59665"
    ],
    "model": {
      "build": "GRCh38",
      "release": "v1.5",
      "chrom": "8",
      "start": 6977649,
      "end": 6980092,
      "strand": "-",
      "ensemblTranscript": "ENST00000382692.3",
      "refseqTranscript": "NM_004084.4",
      "ensemblProtein": "ENSP00000372139.2",
      "refseqProtein": "NP_004075.1",
      "exons": [
        {
          "start": 6977649,
          "end": 6977879
        },
        {
          "start": 6978460,
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        },
        {
          "start": 6980013,
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        }
      ],
      "cds": {
        "start": 6977770,
        "end": 6978634
      }
    },
    "grch37": {
      "build": "GRCh37",
      "release": "87",
      "chrom": "8",
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      "end": 6837602,
      "strand": "-"
    },
    "neighbourhood": {
      "release": "116",
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      "end": 7478870,
      "genes": [
        {
          "symbol": "MCPH1",
          "ensemblId": "ENSG00000147316",
          "biotype": "protein_coding",
          "start": 6406592,
          "end": 6648508,
          "strand": "+",
          "slug": "mcph1"
        },
        {
          "symbol": "ANGPT2",
          "ensemblId": "ENSG00000091879",
          "biotype": "protein_coding",
          "start": 6499632,
          "end": 6563436,
          "strand": "-",
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        },
        {
          "symbol": "AGPAT5",
          "ensemblId": "ENSG00000155189",
          "biotype": "protein_coding",
          "start": 6708334,
          "end": 6761604,
          "strand": "+",
          "slug": "agpat5"
        },
        {
          "symbol": "XKR5",
          "ensemblId": "ENSG00000275591",
          "biotype": "protein_coding",
          "start": 6805013,
          "end": 6835536,
          "strand": "-",
          "slug": "xkr5"
        },
        {
          "symbol": "DEFB1",
          "ensemblId": "ENSG00000164825",
          "biotype": "protein_coding",
          "start": 6870592,
          "end": 6877943,
          "strand": "-",
          "slug": "defb1"
        },
        {
          "symbol": "DEFA6",
          "ensemblId": "ENSG00000164822",
          "biotype": "protein_coding",
          "start": 6924697,
          "end": 6926076,
          "strand": "-",
          "slug": "defa6"
        },
        {
          "symbol": "DEFA4",
          "ensemblId": "ENSG00000164821",
          "biotype": "protein_coding",
          "start": 6935820,
          "end": 6938313,
          "strand": "-",
          "slug": "defa4"
        },
        {
          "symbol": "DEFA1B",
          "ensemblId": "ENSG00000240247",
          "biotype": "protein_coding",
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          "end": 6999206,
          "strand": "-",
          "slug": "defa1b"
        },
        {
          "symbol": "DEFA3",
          "ensemblId": "ENSG00000239839",
          "biotype": "protein_coding",
          "start": 7015868,
          "end": 7018359,
          "strand": "-",
          "slug": "defa3"
        },
        {
          "symbol": "DEFA5",
          "ensemblId": "ENSG00000164816",
          "biotype": "protein_coding",
          "start": 7055251,
          "end": 7056740,
          "strand": "-",
          "slug": "defa5"
        },
        {
          "symbol": "FAM90A15",
          "ensemblId": "ENSG00000230045",
          "biotype": "protein_coding",
          "start": 7256904,
          "end": 7259914,
          "strand": "+",
          "slug": "fam90a15"
        },
        {
          "symbol": "FAM90A3",
          "ensemblId": "ENSG00000233132",
          "biotype": "protein_coding",
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        },
        {
          "symbol": "FAM90A13",
          "ensemblId": "ENSG00000223885",
          "biotype": "protein_coding",
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        {
          "symbol": "FAM90A5",
          "ensemblId": "ENSG00000215373",
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        },
        {
          "symbol": "FAM90A20",
          "ensemblId": "ENSG00000233295",
          "biotype": "protein_coding",
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        },
        {
          "symbol": "DEFB109B",
          "ensemblId": "ENSG00000206034",
          "biotype": "protein_coding",
          "start": 7312722,
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          "strand": "+",
          "slug": "defb109b"
        },
        {
          "symbol": "USP17L1",
          "ensemblId": "ENSG00000230549",
          "biotype": "protein_coding",
          "start": 7332387,
          "end": 7333979,
          "strand": "+",
          "slug": "usp17l1"
        },
        {
          "symbol": "USP17L4",
          "ensemblId": "ENSG00000236125",
          "biotype": "protein_coding",
          "start": 7337115,
          "end": 7338707,
          "strand": "+",
          "slug": "usp17l4"
        },
        {
          "symbol": "ZNF705G",
          "ensemblId": "ENSG00000215372",
          "biotype": "protein_coding",
          "start": 7355517,
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          "strand": "-",
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        },
        {
          "symbol": "DEFB108C",
          "ensemblId": "ENSG00000215371",
          "biotype": "protein_coding",
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          "strand": "+",
          "slug": "defb108c"
        },
        {
          "symbol": "DEFB4B",
          "ensemblId": "ENSG00000177257",
          "biotype": "protein_coding",
          "start": 7414855,
          "end": 7416863,
          "strand": "-",
          "slug": "defb4b"
        },
        {
          "symbol": "DEFB103B",
          "ensemblId": "ENSG00000177243",
          "biotype": "protein_coding",
          "start": 7428888,
          "end": 7430348,
          "strand": "-",
          "slug": "defb103b"
        },
        {
          "symbol": "SPAG11B",
          "ensemblId": "ENSG00000164871",
          "biotype": "protein_coding",
          "start": 7442684,
          "end": 7463674,
          "strand": "-",
          "slug": "spag11b"
        },
        {
          "symbol": "DEFB104B",
          "ensemblId": "ENSG00000177023",
          "biotype": "protein_coding",
          "start": 7470308,
          "end": 7475082,
          "strand": "-",
          "slug": "defb104b"
        }
      ],
      "truncated": false
    },
    "reports": [],
    "pharmacogenomics": [],
    "traits": [],
    "phenotypes": [],
    "related": [],
    "sources": null,
    "locusKind": "proteinCoding"
  },
  "variants": {
    "total": 0,
    "url": null,
    "items": []
  }
}