{
  "url": "https://dantelabs.com/traits/tachypnea",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "tachypnea",
    "id": "HP:0002789",
    "name": "Increased respiratory rate or depth of breathing",
    "label": "Tachypnea",
    "definition": "Very rapid breathing.",
    "synonyms": [
      "Polypnea"
    ],
    "systems": [
      {
        "slug": "abnormality-of-the-respiratory-system",
        "name": "Abnormality of the respiratory system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-respiratory-system"
      }
    ],
    "broader": [
      {
        "slug": "abnormal-pattern-of-respiration",
        "name": "Abnormal pattern of respiration",
        "url": "https://dantelabs.com/traits/abnormal-pattern-of-respiration"
      }
    ],
    "narrower": [
      {
        "slug": "episodic-tachypnea",
        "name": "Episodic tachypnea",
        "genes": 46,
        "url": "https://dantelabs.com/traits/episodic-tachypnea"
      }
    ],
    "genes": [
      {
        "slug": "atp5f1b",
        "symbol": "ATP5F1B",
        "hgnc": "HGNC:830",
        "name": "ATP synthase F1 subunit beta",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/atp5f1b"
      },
      {
        "slug": "bola3",
        "symbol": "BOLA3",
        "hgnc": "HGNC:24415",
        "name": "bolA family member 3",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/bola3"
      },
      {
        "slug": "coa6",
        "symbol": "COA6",
        "hgnc": "HGNC:18025",
        "name": "cytochrome c oxidase assembly factor 6",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/coa6"
      },
      {
        "slug": "dmrt2",
        "symbol": "DMRT2",
        "hgnc": "HGNC:2935",
        "name": "doublesex and mab-3 related transcription factor 2",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dmrt2"
      },
      {
        "slug": "farsb",
        "symbol": "FARSB",
        "hgnc": "HGNC:17800",
        "name": "phenylalanyl-tRNA synthetase subunit beta",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/farsb"
      },
      {
        "slug": "get3",
        "symbol": "GET3",
        "hgnc": "HGNC:752",
        "name": "guided entry of tail-anchored proteins factor 3, ATPase",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/get3"
      },
      {
        "slug": "lyrm7",
        "symbol": "LYRM7",
        "hgnc": "HGNC:28072",
        "name": "LYR motif containing 7",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lyrm7"
      },
      {
        "slug": "ptcra",
        "symbol": "PTCRA",
        "hgnc": "HGNC:21290",
        "name": "pre T cell antigen receptor alpha",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ptcra"
      },
      {
        "slug": "sco2",
        "symbol": "SCO2",
        "hgnc": "HGNC:10604",
        "name": "synthesis of cytochrome C oxidase 2",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sco2"
      },
      {
        "slug": "sftpc",
        "symbol": "SFTPC",
        "hgnc": "HGNC:10802",
        "name": "surfactant protein C",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/sftpc"
      },
      {
        "slug": "tm2d3",
        "symbol": "TM2D3",
        "hgnc": "HGNC:24128",
        "name": "TM2 domain containing 3",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tm2d3"
      },
      {
        "slug": "acat1",
        "symbol": "ACAT1",
        "hgnc": "HGNC:93",
        "name": "acetyl-CoA acetyltransferase 1",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/acat1"
      },
      {
        "slug": "acta2",
        "symbol": "ACTA2",
        "hgnc": "HGNC:130",
        "name": "actin alpha 2, smooth muscle",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/acta2"
      },
      {
        "slug": "cc2d2a",
        "symbol": "CC2D2A",
        "hgnc": "HGNC:29253",
        "name": "coiled-coil and C2 domain containing 2A",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cc2d2a"
      },
      {
        "slug": "cep290",
        "symbol": "CEP290",
        "hgnc": "HGNC:29021",
        "name": "centrosomal protein 290",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cep290"
      },
      {
        "slug": "sftpb",
        "symbol": "SFTPB",
        "hgnc": "HGNC:10801",
        "name": "surfactant protein B",
        "frequency": "very-frequent",
        "diseases": 3,
        "url": "https://dantelabs.com/genes/sftpb"
      },
      {
        "slug": "tmem138",
        "symbol": "TMEM138",
        "hgnc": "HGNC:26944",
        "name": "transmembrane protein 138",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tmem138"
      },
      {
        "slug": "tmem216",
        "symbol": "TMEM216",
        "hgnc": "HGNC:25018",
        "name": "transmembrane protein 216",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tmem216"
      },
      {
        "slug": "tmem231",
        "symbol": "TMEM231",
        "hgnc": "HGNC:37234",
        "name": "transmembrane protein 231",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tmem231"
      },
      {
        "slug": "tmem237",
        "symbol": "TMEM237",
        "hgnc": "HGNC:14432",
        "name": "transmembrane protein 237",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tmem237"
      },
      {
        "slug": "znf423",
        "symbol": "ZNF423",
        "hgnc": "HGNC:16762",
        "name": "zinc finger protein 423",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/znf423"
      },
      {
        "slug": "abca3",
        "symbol": "ABCA3",
        "hgnc": "HGNC:33",
        "name": "ATP binding cassette subfamily A member 3",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/abca3"
      },
      {
        "slug": "asl",
        "symbol": "ASL",
        "hgnc": "HGNC:746",
        "name": "argininosuccinate lyase",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/asl"
      },
      {
        "slug": "ca5a",
        "symbol": "CA5A",
        "hgnc": "HGNC:1377",
        "name": "carbonic anhydrase 5A",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ca5a"
      },
      {
        "slug": "cacna1s",
        "symbol": "CACNA1S",
        "hgnc": "HGNC:1397",
        "name": "calcium voltage-gated channel subunit alpha1 S",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cacna1s"
      },
      {
        "slug": "cspp1",
        "symbol": "CSPP1",
        "hgnc": "HGNC:26193",
        "name": "centrosome and spindle pole associated protein 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cspp1"
      },
      {
        "slug": "hlcs",
        "symbol": "HLCS",
        "hgnc": "HGNC:4976",
        "name": "holocarboxylase synthetase",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/hlcs"
      },
      {
        "slug": "hmgcl",
        "symbol": "HMGCL",
        "hgnc": "HGNC:5005",
        "name": "3-hydroxy-3-methylglutaryl-CoA lyase",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hmgcl"
      },
      {
        "slug": "kiaa0586",
        "symbol": "KIAA0586",
        "hgnc": "HGNC:19960",
        "name": "KIAA0586",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/kiaa0586"
      },
      {
        "slug": "nags",
        "symbol": "NAGS",
        "hgnc": "HGNC:17996",
        "name": "N-acetylglutamate synthase",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nags"
      },
      {
        "slug": "nkx2-1",
        "symbol": "NKX2-1",
        "hgnc": "HGNC:11825",
        "name": "NK2 homeobox 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nkx2-1"
      },
      {
        "slug": "oxct1",
        "symbol": "OXCT1",
        "hgnc": "HGNC:8527",
        "name": "3-oxoacid CoA-transferase 1",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/oxct1"
      },
      {
        "slug": "plxnd1",
        "symbol": "PLXND1",
        "hgnc": "HGNC:9107",
        "name": "plexin D1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/plxnd1"
      },
      {
        "slug": "ryr1",
        "symbol": "RYR1",
        "hgnc": "HGNC:10483",
        "name": "ryanodine receptor 1",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/ryr1"
      },
      {
        "slug": "slc25a15",
        "symbol": "SLC25A15",
        "hgnc": "HGNC:10985",
        "name": "solute carrier family 25 member 15",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slc25a15"
      },
      {
        "slug": "sting1",
        "symbol": "STING1",
        "hgnc": "HGNC:27962",
        "name": "stimulator of interferon response cGAMP interactor 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sting1"
      },
      {
        "slug": "armc9",
        "symbol": "ARMC9",
        "hgnc": "HGNC:20730",
        "name": "armadillo repeat containing 9",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/armc9"
      },
      {
        "slug": "arsl",
        "symbol": "ARSL",
        "hgnc": "HGNC:719",
        "name": "arylsulfatase L",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/arsl"
      },
      {
        "slug": "btd",
        "symbol": "BTD",
        "hgnc": "HGNC:1122",
        "name": "biotinidase",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/btd"
      },
      {
        "slug": "copa",
        "symbol": "COPA",
        "hgnc": "HGNC:2230",
        "name": "coat protein complex I subunit alpha",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/copa"
      },
      {
        "slug": "csf2ra",
        "symbol": "CSF2RA",
        "hgnc": "HGNC:2435",
        "name": "colony stimulating factor 2 receptor subunit alpha",
        "frequency": "occasional",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/csf2ra"
      },
      {
        "slug": "csf2rb",
        "symbol": "CSF2RB",
        "hgnc": "HGNC:2436",
        "name": "colony stimulating factor 2 receptor subunit beta",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/csf2rb"
      },
      {
        "slug": "mt-cyb",
        "symbol": "MT-CYB",
        "hgnc": "HGNC:7427",
        "name": "mitochondrially encoded cytochrome b",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mt-cyb"
      },
      {
        "slug": "nek1",
        "symbol": "NEK1",
        "hgnc": "HGNC:7744",
        "name": "NIMA related kinase 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nek1"
      },
      {
        "slug": "rhag",
        "symbol": "RHAG",
        "hgnc": "HGNC:10006",
        "name": "Rh associated glycoprotein",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rhag"
      },
      {
        "slug": "rhce",
        "symbol": "RHCE",
        "hgnc": "HGNC:10008",
        "name": "Rh blood group CcEe antigens",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rhce"
      },
      {
        "slug": "rhd",
        "symbol": "RHD",
        "hgnc": "HGNC:10009",
        "name": "Rh blood group D antigen",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rhd"
      },
      {
        "slug": "slc34a2",
        "symbol": "SLC34A2",
        "hgnc": "HGNC:11020",
        "name": "solute carrier family 34 member 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slc34a2"
      },
      {
        "slug": "tll1",
        "symbol": "TLL1",
        "hgnc": "HGNC:11843",
        "name": "tolloid like 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tll1"
      },
      {
        "slug": "acadvl",
        "symbol": "ACADVL",
        "hgnc": "HGNC:92",
        "name": "acyl-CoA dehydrogenase very long chain",
        "frequency": "very-rare",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/acadvl"
      },
      {
        "slug": "abcd4",
        "symbol": "ABCD4",
        "hgnc": "HGNC:68",
        "name": "ATP binding cassette subfamily D member 4",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/abcd4"
      },
      {
        "slug": "casr",
        "symbol": "CASR",
        "hgnc": "HGNC:1514",
        "name": "calcium sensing receptor",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/casr"
      },
      {
        "slug": "ighmbp2",
        "symbol": "IGHMBP2",
        "hgnc": "HGNC:5542",
        "name": "immunoglobulin mu DNA binding protein 2",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ighmbp2"
      },
      {
        "slug": "lrpprc",
        "symbol": "LRPPRC",
        "hgnc": "HGNC:15714",
        "name": "leucine rich pentatricopeptide repeat containing",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lrpprc"
      },
      {
        "slug": "pam16",
        "symbol": "PAM16",
        "hgnc": "HGNC:29679",
        "name": "presequence translocase associated motor 16",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pam16"
      },
      {
        "slug": "pcca",
        "symbol": "PCCA",
        "hgnc": "HGNC:8653",
        "name": "propionyl-CoA carboxylase subunit alpha",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pcca"
      },
      {
        "slug": "pccb",
        "symbol": "PCCB",
        "hgnc": "HGNC:8654",
        "name": "propionyl-CoA carboxylase subunit beta",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pccb"
      },
      {
        "slug": "rpgrip1l",
        "symbol": "RPGRIP1L",
        "hgnc": "HGNC:29168",
        "name": "RPGRIP1 like",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rpgrip1l"
      }
    ]
  }
}