{
  "url": "https://dantelabs.com/traits/synovitis",
  "trait": {
    "bundleId": "2026.10.18-8b139e39",
    "release": "2026-09-01",
    "slug": "synovitis",
    "id": "HP:0100769",
    "name": "Synovitis",
    "synonyms": [],
    "systems": [
      {
        "slug": "abnormality-of-the-musculoskeletal-system",
        "name": "Abnormality of the musculoskeletal system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-musculoskeletal-system"
      }
    ],
    "broader": [
      {
        "slug": "abnormal-synovial-membrane-morphology",
        "name": "Abnormal synovial membrane morphology",
        "url": "https://dantelabs.com/traits/abnormal-synovial-membrane-morphology"
      }
    ],
    "narrower": [],
    "genes": [
      {
        "slug": "hyal1",
        "symbol": "HYAL1",
        "hgnc": "HGNC:5320",
        "name": "hyaluronidase 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hyal1"
      },
      {
        "slug": "nod2",
        "symbol": "NOD2",
        "hgnc": "HGNC:5331",
        "name": "nucleotide binding oligomerization domain containing 2",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/nod2"
      },
      {
        "slug": "ankrd55",
        "symbol": "ANKRD55",
        "hgnc": "HGNC:25681",
        "name": "ankyrin repeat domain 55",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ankrd55"
      },
      {
        "slug": "cd247",
        "symbol": "CD247",
        "hgnc": "HGNC:1677",
        "name": "CD247 molecule",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cd247"
      },
      {
        "slug": "il2ra",
        "symbol": "IL2RA",
        "hgnc": "HGNC:6008",
        "name": "interleukin 2 receptor subunit alpha",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/il2ra"
      },
      {
        "slug": "il2rb",
        "symbol": "IL2RB",
        "hgnc": "HGNC:6009",
        "name": "interleukin 2 receptor subunit beta",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/il2rb"
      },
      {
        "slug": "lpin2",
        "symbol": "LPIN2",
        "hgnc": "HGNC:14450",
        "name": "lipin 2",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lpin2"
      },
      {
        "slug": "polr3a",
        "symbol": "POLR3A",
        "hgnc": "HGNC:30074",
        "name": "RNA polymerase III subunit A",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/polr3a"
      },
      {
        "slug": "ptpn2",
        "symbol": "PTPN2",
        "hgnc": "HGNC:9650",
        "name": "protein tyrosine phosphatase non-receptor type 2",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ptpn2"
      },
      {
        "slug": "ptpn22",
        "symbol": "PTPN22",
        "hgnc": "HGNC:9652",
        "name": "protein tyrosine phosphatase non-receptor type 22",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ptpn22"
      },
      {
        "slug": "stat4",
        "symbol": "STAT4",
        "hgnc": "HGNC:11365",
        "name": "signal transducer and activator of transcription 4",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/stat4"
      },
      {
        "slug": "ankh",
        "symbol": "ANKH",
        "hgnc": "HGNC:15492",
        "name": "ANKH inorganic pyrophosphate transport regulator",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ankh"
      },
      {
        "slug": "f8",
        "symbol": "F8",
        "hgnc": "HGNC:3546",
        "name": "coagulation factor VIII",
        "frequency": "occasional",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/f8"
      },
      {
        "slug": "tnfrsf11b",
        "symbol": "TNFRSF11B",
        "hgnc": "HGNC:11909",
        "name": "TNF receptor superfamily member 11b",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tnfrsf11b"
      },
      {
        "slug": "braf",
        "symbol": "BRAF",
        "hgnc": "HGNC:1097",
        "name": "B-Raf proto-oncogene, serine/threonine kinase",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/braf"
      },
      {
        "slug": "map2k1",
        "symbol": "MAP2K1",
        "hgnc": "HGNC:6840",
        "name": "mitogen-activated protein kinase kinase 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/map2k1"
      },
      {
        "slug": "ptpn11",
        "symbol": "PTPN11",
        "hgnc": "HGNC:9644",
        "name": "protein tyrosine phosphatase non-receptor type 11",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ptpn11"
      },
      {
        "slug": "trappc2",
        "symbol": "TRAPPC2",
        "hgnc": "HGNC:23068",
        "name": "trafficking protein particle complex subunit 2",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/trappc2"
      }
    ]
  }
}