{
  "url": "https://dantelabs.com/traits/periorificial-hyperkeratosis",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "periorificial-hyperkeratosis",
    "id": "HP:0034521",
    "name": "Periorificial hyperkeratosis",
    "definition": "Scaling and overgrowth of horny tissue of the skin surrounding body orifices (including peri-auricular, peri-oral, peri-anal areas.",
    "synonyms": [],
    "systems": [
      {
        "slug": "abnormality-of-the-integument",
        "name": "Abnormality of the integument",
        "url": "https://dantelabs.com/traits/abnormality-of-the-integument"
      }
    ],
    "broader": [
      {
        "slug": "hyperkeratosis",
        "name": "Hyperkeratosis",
        "url": "https://dantelabs.com/traits/hyperkeratosis"
      }
    ],
    "narrower": [
      {
        "slug": "perioral-hyperkeratosis",
        "name": "Perioral hyperkeratosis",
        "genes": 2,
        "url": "https://dantelabs.com/traits/perioral-hyperkeratosis"
      }
    ],
    "genes": [
      {
        "slug": "trpv3",
        "symbol": "TRPV3",
        "hgnc": "HGNC:18084",
        "name": "transient receptor potential cation channel subfamily V member 3",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/trpv3"
      }
    ]
  }
}