{
  "url": "https://dantelabs.com/traits/periorbital-hyperpigmentation",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "periorbital-hyperpigmentation",
    "id": "HP:0001106",
    "name": "Dark circles around the eyes",
    "label": "Periorbital hyperpigmentation",
    "definition": "Increased pigmentation of the skin in the region surrounding the orbit of the eye.",
    "synonyms": [
      "Dark circles under the eyes",
      "Darkening around the eyes",
      "Pigmentation around the eyes",
      "Idiopathic cutaneous hyperchromia at the orbital region",
      "Infraorbital pigmentation",
      "Periorbital melanosis"
    ],
    "systems": [
      {
        "slug": "abnormality-of-head-or-neck",
        "name": "Abnormality of head or neck",
        "url": "https://dantelabs.com/traits/abnormality-of-head-or-neck"
      },
      {
        "slug": "abnormality-of-the-integument",
        "name": "Abnormality of the integument",
        "url": "https://dantelabs.com/traits/abnormality-of-the-integument"
      }
    ],
    "broader": [
      {
        "slug": "abnormal-skin-pigmentation",
        "name": "Abnormal skin pigmentation",
        "url": "https://dantelabs.com/traits/abnormal-skin-pigmentation"
      },
      {
        "slug": "abnormality-of-the-periorbital-region",
        "name": "Abnormality of the region around the eye",
        "url": "https://dantelabs.com/traits/abnormality-of-the-periorbital-region"
      }
    ],
    "narrower": [],
    "genes": [
      {
        "slug": "eda",
        "symbol": "EDA",
        "hgnc": "HGNC:3157",
        "name": "ectodysplasin A",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/eda"
      },
      {
        "slug": "edar",
        "symbol": "EDAR",
        "hgnc": "HGNC:2895",
        "name": "ectodysplasin A receptor",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/edar"
      },
      {
        "slug": "edaradd",
        "symbol": "EDARADD",
        "hgnc": "HGNC:14341",
        "name": "EDAR associated via death domain",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/edaradd"
      },
      {
        "slug": "kif15",
        "symbol": "KIF15",
        "hgnc": "HGNC:17273",
        "name": "kinesin family member 15",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/kif15"
      }
    ]
  }
}