{
  "url": "https://dantelabs.com/traits/optic-nerve-compression",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "optic-nerve-compression",
    "id": "HP:0007807",
    "name": "Optic nerve compression",
    "synonyms": [],
    "systems": [
      {
        "slug": "abnormality-of-the-eye",
        "name": "Abnormality of the eye",
        "url": "https://dantelabs.com/traits/abnormality-of-the-eye"
      },
      {
        "slug": "abnormality-of-the-nervous-system",
        "name": "Abnormality of the nervous system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-nervous-system"
      }
    ],
    "broader": [
      {
        "slug": "cranial-nerve-compression",
        "name": "Cranial nerve compression",
        "url": "https://dantelabs.com/traits/cranial-nerve-compression"
      },
      {
        "slug": "abnormal-optic-nerve-morphology",
        "name": "Optic nerve issue",
        "url": "https://dantelabs.com/traits/abnormal-optic-nerve-morphology"
      }
    ],
    "narrower": [],
    "genes": [
      {
        "slug": "clcn7",
        "symbol": "CLCN7",
        "hgnc": "HGNC:2025",
        "name": "Cl-/H+ antiporter 7",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/clcn7"
      },
      {
        "slug": "ostm1",
        "symbol": "OSTM1",
        "hgnc": "HGNC:21652",
        "name": "osteoclastogenesis associated transmembrane protein 1",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ostm1"
      },
      {
        "slug": "snx10",
        "symbol": "SNX10",
        "hgnc": "HGNC:14974",
        "name": "sorting nexin 10",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/snx10"
      },
      {
        "slug": "tcirg1",
        "symbol": "TCIRG1",
        "hgnc": "HGNC:11647",
        "name": "T cell immune regulator 1, ATPase H+ transporting V0 subunit a3",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tcirg1"
      },
      {
        "slug": "tnfsf11",
        "symbol": "TNFSF11",
        "hgnc": "HGNC:11926",
        "name": "TNF superfamily member 11",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tnfsf11"
      },
      {
        "slug": "tgfb1",
        "symbol": "TGFB1",
        "hgnc": "HGNC:11766",
        "name": "transforming growth factor beta 1",
        "frequency": "occasional",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/tgfb1"
      },
      {
        "slug": "tmem53",
        "symbol": "TMEM53",
        "hgnc": "HGNC:26186",
        "name": "transmembrane protein 53",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tmem53"
      },
      {
        "slug": "atrx",
        "symbol": "ATRX",
        "hgnc": "HGNC:886",
        "name": "ATRX chromatin remodeler",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/atrx"
      },
      {
        "slug": "braf",
        "symbol": "BRAF",
        "hgnc": "HGNC:1097",
        "name": "B-Raf proto-oncogene, serine/threonine kinase",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/braf"
      },
      {
        "slug": "cdh23",
        "symbol": "CDH23",
        "hgnc": "HGNC:13733",
        "name": "cadherin related 23",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cdh23"
      },
      {
        "slug": "nr3c1",
        "symbol": "NR3C1",
        "hgnc": "HGNC:7978",
        "name": "nuclear receptor subfamily 3 group C member 1",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nr3c1"
      },
      {
        "slug": "tp53",
        "symbol": "TP53",
        "hgnc": "HGNC:11998",
        "name": "tumor protein p53",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tp53"
      },
      {
        "slug": "usp48",
        "symbol": "USP48",
        "hgnc": "HGNC:18533",
        "name": "ubiquitin specific peptidase 48",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/usp48"
      },
      {
        "slug": "usp8",
        "symbol": "USP8",
        "hgnc": "HGNC:12631",
        "name": "ubiquitin specific peptidase 8",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/usp8"
      },
      {
        "slug": "ca2",
        "symbol": "CA2",
        "hgnc": "HGNC:1373",
        "name": "carbonic anhydrase 2",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ca2"
      },
      {
        "slug": "tnfrsf11a",
        "symbol": "TNFRSF11A",
        "hgnc": "HGNC:11908",
        "name": "TNF receptor superfamily member 11a",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tnfrsf11a"
      }
    ]
  }
}