{
  "url": "https://dantelabs.com/traits/meconium-ileus",
  "trait": {
    "bundleId": "2026.10.19-9814e911",
    "release": "2026-09-01",
    "slug": "meconium-ileus",
    "id": "HP:0004401",
    "name": "Meconium ileus",
    "definition": "Obstruction of the intestine due to abnormally thick meconium.",
    "synonyms": [
      "Meconium ileus in neonates"
    ],
    "systems": [
      {
        "slug": "abnormality-of-the-digestive-system",
        "name": "Abnormality of the digestive system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-digestive-system"
      }
    ],
    "broader": [
      {
        "slug": "mechanical-ileus",
        "name": "Mechanical ileus",
        "url": "https://dantelabs.com/traits/mechanical-ileus"
      }
    ],
    "narrower": [],
    "genes": [
      {
        "slug": "gucy2c",
        "symbol": "GUCY2C",
        "hgnc": "HGNC:4688",
        "name": "guanylate cyclase 2C",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gucy2c"
      },
      {
        "slug": "slc18a3",
        "symbol": "SLC18A3",
        "hgnc": "HGNC:10936",
        "name": "solute carrier family 18 member A3",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slc18a3"
      },
      {
        "slug": "ceacam3",
        "symbol": "CEACAM3",
        "hgnc": "HGNC:1815",
        "name": "CEA cell adhesion molecule 3",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ceacam3"
      },
      {
        "slug": "ceacam6",
        "symbol": "CEACAM6",
        "hgnc": "HGNC:1818",
        "name": "CEA cell adhesion molecule 6",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ceacam6"
      },
      {
        "slug": "cftr",
        "symbol": "CFTR",
        "hgnc": "HGNC:1884",
        "name": "CF transmembrane conductance regulator",
        "frequency": "occasional",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/cftr"
      },
      {
        "slug": "clca4",
        "symbol": "CLCA4",
        "hgnc": "HGNC:2018",
        "name": "chloride channel accessory 4",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/clca4"
      },
      {
        "slug": "dctn4",
        "symbol": "DCTN4",
        "hgnc": "HGNC:15518",
        "name": "dynactin subunit 4",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dctn4"
      },
      {
        "slug": "ednra",
        "symbol": "EDNRA",
        "hgnc": "HGNC:3179",
        "name": "endothelin receptor type A",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ednra"
      },
      {
        "slug": "gclc",
        "symbol": "GCLC",
        "hgnc": "HGNC:4311",
        "name": "glutamate-cysteine ligase catalytic subunit",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gclc"
      },
      {
        "slug": "gstm3",
        "symbol": "GSTM3",
        "hgnc": "HGNC:4635",
        "name": "glutathione S-transferase mu 3",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gstm3"
      },
      {
        "slug": "hfe",
        "symbol": "HFE",
        "hgnc": "HGNC:4886",
        "name": "homeostatic iron regulator",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hfe"
      },
      {
        "slug": "hmox1",
        "symbol": "HMOX1",
        "hgnc": "HGNC:5013",
        "name": "heme oxygenase 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hmox1"
      },
      {
        "slug": "kcnn4",
        "symbol": "KCNN4",
        "hgnc": "HGNC:6293",
        "name": "potassium calcium-activated channel subfamily N member 4",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/kcnn4"
      },
      {
        "slug": "mif",
        "symbol": "MIF",
        "hgnc": "HGNC:7097",
        "name": "macrophage migration inhibitory factor",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mif"
      },
      {
        "slug": "serpina1",
        "symbol": "SERPINA1",
        "hgnc": "HGNC:8941",
        "name": "serpin family A member 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/serpina1"
      },
      {
        "slug": "slc11a1",
        "symbol": "SLC11A1",
        "hgnc": "HGNC:10907",
        "name": "solute carrier family 11 member 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slc11a1"
      },
      {
        "slug": "slc26a9",
        "symbol": "SLC26A9",
        "hgnc": "HGNC:14469",
        "name": "solute carrier family 26 member 9",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slc26a9"
      },
      {
        "slug": "slc6a14",
        "symbol": "SLC6A14",
        "hgnc": "HGNC:11047",
        "name": "solute carrier family 6 member 14",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slc6a14"
      },
      {
        "slug": "slc9a3",
        "symbol": "SLC9A3",
        "hgnc": "HGNC:11073",
        "name": "solute carrier family 9 member A3",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slc9a3"
      },
      {
        "slug": "stx1a",
        "symbol": "STX1A",
        "hgnc": "HGNC:11433",
        "name": "syntaxin 1A",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/stx1a"
      },
      {
        "slug": "tgfb1",
        "symbol": "TGFB1",
        "hgnc": "HGNC:11766",
        "name": "transforming growth factor beta 1",
        "frequency": "occasional",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/tgfb1"
      },
      {
        "slug": "fcgr2a",
        "symbol": "FCGR2A",
        "hgnc": "HGNC:3616",
        "name": "Fc gamma receptor IIa",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fcgr2a"
      }
    ]
  }
}