{
  "url": "https://dantelabs.com/traits/limb-pain",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "limb-pain",
    "id": "HP:0009763",
    "name": "Limb pain",
    "definition": "Chronic pain in the limbs with no clear focal etiology.",
    "synonyms": [
      "Pain in extremities"
    ],
    "systems": [
      {
        "slug": "abnormality-of-the-musculoskeletal-system",
        "name": "Abnormality of the musculoskeletal system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-musculoskeletal-system"
      },
      {
        "slug": "constitutional-symptom",
        "name": "Constitutional symptom",
        "url": "https://dantelabs.com/traits/constitutional-symptom"
      }
    ],
    "broader": [
      {
        "slug": "abnormal-musculoskeletal-physiology",
        "name": "Abnormal musculoskeletal physiology",
        "url": "https://dantelabs.com/traits/abnormal-musculoskeletal-physiology"
      },
      {
        "slug": "pain",
        "name": "Pain",
        "url": "https://dantelabs.com/traits/pain"
      }
    ],
    "narrower": [
      {
        "slug": "lower-limb-pain",
        "name": "Lower limb pain",
        "genes": 22,
        "url": "https://dantelabs.com/traits/lower-limb-pain"
      },
      {
        "slug": "upper-limb-pain",
        "name": "Upper limb pain",
        "genes": 6,
        "url": "https://dantelabs.com/traits/upper-limb-pain"
      }
    ],
    "genes": [
      {
        "slug": "gys1",
        "symbol": "GYS1",
        "hgnc": "HGNC:4706",
        "name": "glycogen synthase 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gys1"
      },
      {
        "slug": "atl1",
        "symbol": "ATL1",
        "hgnc": "HGNC:11231",
        "name": "atlastin GTPase 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/atl1"
      },
      {
        "slug": "atl3",
        "symbol": "ATL3",
        "hgnc": "HGNC:24526",
        "name": "atlastin GTPase 3",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/atl3"
      },
      {
        "slug": "col2a1",
        "symbol": "COL2A1",
        "hgnc": "HGNC:2200",
        "name": "collagen type II alpha 1 chain",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/col2a1"
      },
      {
        "slug": "cpox",
        "symbol": "CPOX",
        "hgnc": "HGNC:2321",
        "name": "coproporphyrinogen oxidase",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cpox"
      },
      {
        "slug": "fn1",
        "symbol": "FN1",
        "hgnc": "HGNC:3778",
        "name": "fibronectin 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fn1"
      },
      {
        "slug": "hmbs",
        "symbol": "HMBS",
        "hgnc": "HGNC:4982",
        "name": "hydroxymethylbilane synthase",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hmbs"
      },
      {
        "slug": "sptlc1",
        "symbol": "SPTLC1",
        "hgnc": "HGNC:11277",
        "name": "serine palmitoyltransferase long chain base subunit 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sptlc1"
      },
      {
        "slug": "sptlc2",
        "symbol": "SPTLC2",
        "hgnc": "HGNC:11278",
        "name": "serine palmitoyltransferase long chain base subunit 2",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sptlc2"
      },
      {
        "slug": "tgfb1",
        "symbol": "TGFB1",
        "hgnc": "HGNC:11766",
        "name": "transforming growth factor beta 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tgfb1"
      },
      {
        "slug": "ccnd1",
        "symbol": "CCND1",
        "hgnc": "HGNC:1582",
        "name": "cyclin D1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ccnd1"
      },
      {
        "slug": "col1a1",
        "symbol": "COL1A1",
        "hgnc": "HGNC:2197",
        "name": "collagen type I alpha 1 chain",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/col1a1"
      },
      {
        "slug": "col5a1",
        "symbol": "COL5A1",
        "hgnc": "HGNC:2209",
        "name": "collagen type V alpha 1 chain",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/col5a1"
      },
      {
        "slug": "col5a2",
        "symbol": "COL5A2",
        "hgnc": "HGNC:2210",
        "name": "collagen type V alpha 2 chain",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/col5a2"
      },
      {
        "slug": "trappc2",
        "symbol": "TRAPPC2",
        "hgnc": "HGNC:23068",
        "name": "trafficking protein particle complex subunit 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/trappc2"
      },
      {
        "slug": "vhl",
        "symbol": "VHL",
        "hgnc": "HGNC:12687",
        "name": "von Hippel-Lindau tumor suppressor",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/vhl"
      },
      {
        "slug": "prkra",
        "symbol": "PRKRA",
        "hgnc": "HGNC:9438",
        "name": "protein activator of interferon induced protein kinase EIF2AK2",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/prkra"
      },
      {
        "slug": "trex1",
        "symbol": "TREX1",
        "hgnc": "HGNC:12269",
        "name": "three prime repair exonuclease 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/trex1"
      }
    ]
  }
}