{
  "url": "https://dantelabs.com/traits/left-ventricular-systolic-dysfunction",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "left-ventricular-systolic-dysfunction",
    "id": "HP:0025169",
    "name": "Left ventricular systolic dysfunction",
    "definition": "Abnormality of left ventricular contraction, often defined operationally as an ejection fraction of less than 40 percent.",
    "synonyms": [],
    "systems": [
      {
        "slug": "abnormality-of-the-cardiovascular-system",
        "name": "Abnormality of the cardiovascular system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-cardiovascular-system"
      }
    ],
    "broader": [
      {
        "slug": "abnormal-left-ventricular-function",
        "name": "Abnormal left ventricular function",
        "url": "https://dantelabs.com/traits/abnormal-left-ventricular-function"
      }
    ],
    "narrower": [
      {
        "slug": "reduced-left-ventricular-ejection-fraction",
        "name": "Reduced left ventricular ejection fraction",
        "genes": 39,
        "url": "https://dantelabs.com/traits/reduced-left-ventricular-ejection-fraction"
      },
      {
        "slug": "abnormal-left-ventricular-endsystolic-diameter",
        "name": "Abnormal left ventricular endsystolic diameter",
        "genes": 0,
        "url": "https://dantelabs.com/traits/abnormal-left-ventricular-endsystolic-diameter"
      }
    ],
    "genes": [
      {
        "slug": "sdhd",
        "symbol": "SDHD",
        "hgnc": "HGNC:10683",
        "name": "succinate dehydrogenase complex subunit D",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sdhd"
      },
      {
        "slug": "slc6a6",
        "symbol": "SLC6A6",
        "hgnc": "HGNC:11052",
        "name": "solute carrier family 6 member 6",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slc6a6"
      },
      {
        "slug": "sox17",
        "symbol": "SOX17",
        "hgnc": "HGNC:18122",
        "name": "SRY-box transcription factor 17",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sox17"
      },
      {
        "slug": "abcc9",
        "symbol": "ABCC9",
        "hgnc": "HGNC:60",
        "name": "ATP binding cassette subfamily C member 9",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/abcc9"
      },
      {
        "slug": "actc1",
        "symbol": "ACTC1",
        "hgnc": "HGNC:143",
        "name": "actin alpha cardiac muscle 1",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/actc1"
      },
      {
        "slug": "actn2",
        "symbol": "ACTN2",
        "hgnc": "HGNC:164",
        "name": "actinin alpha 2",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/actn2"
      },
      {
        "slug": "ankrd1",
        "symbol": "ANKRD1",
        "hgnc": "HGNC:15819",
        "name": "ankyrin repeat domain 1",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ankrd1"
      },
      {
        "slug": "bag3",
        "symbol": "BAG3",
        "hgnc": "HGNC:939",
        "name": "BAG cochaperone 3",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/bag3"
      },
      {
        "slug": "bag5",
        "symbol": "BAG5",
        "hgnc": "HGNC:941",
        "name": "BAG cochaperone 5",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/bag5"
      },
      {
        "slug": "cap2",
        "symbol": "CAP2",
        "hgnc": "HGNC:20039",
        "name": "cyclase associated actin cytoskeleton regulatory protein 2",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cap2"
      },
      {
        "slug": "cryab",
        "symbol": "CRYAB",
        "hgnc": "HGNC:2389",
        "name": "crystallin alpha B",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cryab"
      },
      {
        "slug": "csrp3",
        "symbol": "CSRP3",
        "hgnc": "HGNC:2472",
        "name": "cysteine and glycine rich protein 3",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/csrp3"
      },
      {
        "slug": "des",
        "symbol": "DES",
        "hgnc": "HGNC:2770",
        "name": "desmin",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/des"
      },
      {
        "slug": "dmd",
        "symbol": "DMD",
        "hgnc": "HGNC:2928",
        "name": "dystrophin",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dmd"
      },
      {
        "slug": "dolk",
        "symbol": "DOLK",
        "hgnc": "HGNC:23406",
        "name": "dolichol kinase",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dolk"
      },
      {
        "slug": "dsg2",
        "symbol": "DSG2",
        "hgnc": "HGNC:3049",
        "name": "desmoglein 2",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dsg2"
      },
      {
        "slug": "dsp",
        "symbol": "DSP",
        "hgnc": "HGNC:3052",
        "name": "desmoplakin",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dsp"
      },
      {
        "slug": "fhl2",
        "symbol": "FHL2",
        "hgnc": "HGNC:3703",
        "name": "four and a half LIM domains 2",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fhl2"
      },
      {
        "slug": "fktn",
        "symbol": "FKTN",
        "hgnc": "HGNC:3622",
        "name": "fukutin",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fktn"
      },
      {
        "slug": "flnc",
        "symbol": "FLNC",
        "hgnc": "HGNC:3756",
        "name": "filamin C",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/flnc"
      },
      {
        "slug": "gatad1",
        "symbol": "GATAD1",
        "hgnc": "HGNC:29941",
        "name": "GATA zinc finger domain containing 1",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gatad1"
      },
      {
        "slug": "get3",
        "symbol": "GET3",
        "hgnc": "HGNC:752",
        "name": "guided entry of tail-anchored proteins factor 3, ATPase",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/get3"
      },
      {
        "slug": "hand2",
        "symbol": "HAND2",
        "hgnc": "HGNC:4808",
        "name": "heart and neural crest derivatives expressed 2",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hand2"
      },
      {
        "slug": "jph2",
        "symbol": "JPH2",
        "hgnc": "HGNC:14202",
        "name": "junctophilin 2",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/jph2"
      },
      {
        "slug": "lama4",
        "symbol": "LAMA4",
        "hgnc": "HGNC:6484",
        "name": "laminin subunit alpha 4",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lama4"
      },
      {
        "slug": "ldb3",
        "symbol": "LDB3",
        "hgnc": "HGNC:15710",
        "name": "LIM domain binding 3",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ldb3"
      },
      {
        "slug": "lmna",
        "symbol": "LMNA",
        "hgnc": "HGNC:6636",
        "name": "lamin A/C",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/lmna"
      },
      {
        "slug": "lmod2",
        "symbol": "LMOD2",
        "hgnc": "HGNC:6648",
        "name": "leiomodin 2",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lmod2"
      },
      {
        "slug": "mybpc3",
        "symbol": "MYBPC3",
        "hgnc": "HGNC:7551",
        "name": "myosin binding protein C3",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mybpc3"
      },
      {
        "slug": "myh6",
        "symbol": "MYH6",
        "hgnc": "HGNC:7576",
        "name": "myosin heavy chain 6",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/myh6"
      },
      {
        "slug": "myh7",
        "symbol": "MYH7",
        "hgnc": "HGNC:7577",
        "name": "myosin heavy chain 7",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/myh7"
      },
      {
        "slug": "mypn",
        "symbol": "MYPN",
        "hgnc": "HGNC:23246",
        "name": "myopalladin",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mypn"
      },
      {
        "slug": "nexn",
        "symbol": "NEXN",
        "hgnc": "HGNC:29557",
        "name": "nexilin F-actin binding protein",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nexn"
      },
      {
        "slug": "nrap",
        "symbol": "NRAP",
        "hgnc": "HGNC:7988",
        "name": "nebulin related anchoring protein",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nrap"
      },
      {
        "slug": "pln",
        "symbol": "PLN",
        "hgnc": "HGNC:9080",
        "name": "phospholamban",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pln"
      },
      {
        "slug": "ppcs",
        "symbol": "PPCS",
        "hgnc": "HGNC:25686",
        "name": "phosphopantothenoylcysteine synthetase",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ppcs"
      },
      {
        "slug": "ppp1r13l",
        "symbol": "PPP1R13L",
        "hgnc": "HGNC:18838",
        "name": "protein phosphatase 1 regulatory subunit 13 like",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ppp1r13l"
      },
      {
        "slug": "prdm16",
        "symbol": "PRDM16",
        "hgnc": "HGNC:14000",
        "name": "PR/SET domain 16",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/prdm16"
      },
      {
        "slug": "psen1",
        "symbol": "PSEN1",
        "hgnc": "HGNC:9508",
        "name": "presenilin 1",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/psen1"
      },
      {
        "slug": "psen2",
        "symbol": "PSEN2",
        "hgnc": "HGNC:9509",
        "name": "presenilin 2",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/psen2"
      },
      {
        "slug": "raf1",
        "symbol": "RAF1",
        "hgnc": "HGNC:9829",
        "name": "Raf-1 proto-oncogene, serine/threonine kinase",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/raf1"
      },
      {
        "slug": "rbm20",
        "symbol": "RBM20",
        "hgnc": "HGNC:27424",
        "name": "RNA binding motif protein 20",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/rbm20"
      },
      {
        "slug": "rpl3l",
        "symbol": "RPL3L",
        "hgnc": "HGNC:10351",
        "name": "ribosomal protein L3 like",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rpl3l"
      },
      {
        "slug": "scn5a",
        "symbol": "SCN5A",
        "hgnc": "HGNC:10593",
        "name": "sodium voltage-gated channel alpha subunit 5",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/scn5a"
      },
      {
        "slug": "sdha",
        "symbol": "SDHA",
        "hgnc": "HGNC:10680",
        "name": "succinate dehydrogenase complex flavoprotein subunit A",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sdha"
      },
      {
        "slug": "sgcd",
        "symbol": "SGCD",
        "hgnc": "HGNC:10807",
        "name": "sarcoglycan delta",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sgcd"
      },
      {
        "slug": "taf1a",
        "symbol": "TAF1A",
        "hgnc": "HGNC:11532",
        "name": "TATA-box binding protein associated factor, RNA polymerase I subunit A",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/taf1a"
      },
      {
        "slug": "tafazzin",
        "symbol": "TAFAZZIN",
        "hgnc": "HGNC:11577",
        "name": "tafazzin, phospholipid-lysophospholipid transacylase",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tafazzin"
      },
      {
        "slug": "tcap",
        "symbol": "TCAP",
        "hgnc": "HGNC:11610",
        "name": "titin-cap",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tcap"
      },
      {
        "slug": "tmpo",
        "symbol": "TMPO",
        "hgnc": "HGNC:11875",
        "name": "thymopoietin",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tmpo"
      },
      {
        "slug": "tnnc1",
        "symbol": "TNNC1",
        "hgnc": "HGNC:11943",
        "name": "troponin C1, slow skeletal and cardiac type",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tnnc1"
      },
      {
        "slug": "tnni3",
        "symbol": "TNNI3",
        "hgnc": "HGNC:11947",
        "name": "troponin I3, cardiac type",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tnni3"
      },
      {
        "slug": "tnnt2",
        "symbol": "TNNT2",
        "hgnc": "HGNC:11949",
        "name": "troponin T2, cardiac type",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tnnt2"
      },
      {
        "slug": "tpm1",
        "symbol": "TPM1",
        "hgnc": "HGNC:12010",
        "name": "tropomyosin 1",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tpm1"
      },
      {
        "slug": "ttn",
        "symbol": "TTN",
        "hgnc": "HGNC:12403",
        "name": "titin",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ttn"
      },
      {
        "slug": "txnrd2",
        "symbol": "TXNRD2",
        "hgnc": "HGNC:18155",
        "name": "thioredoxin reductase 2",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/txnrd2"
      },
      {
        "slug": "vcl",
        "symbol": "VCL",
        "hgnc": "HGNC:12665",
        "name": "vinculin",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/vcl"
      },
      {
        "slug": "vezf1",
        "symbol": "VEZF1",
        "hgnc": "HGNC:12949",
        "name": "vascular endothelial zinc finger 1",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/vezf1"
      },
      {
        "slug": "abcc6",
        "symbol": "ABCC6",
        "hgnc": "HGNC:57",
        "name": "ATP binding cassette subfamily C member 6",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/abcc6"
      },
      {
        "slug": "enpp1",
        "symbol": "ENPP1",
        "hgnc": "HGNC:3356",
        "name": "ectonucleotide pyrophosphatase/phosphodiesterase 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/enpp1"
      },
      {
        "slug": "pomt2",
        "symbol": "POMT2",
        "hgnc": "HGNC:19743",
        "name": "protein O-mannosyltransferase 2",
        "frequency": "occasional",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/pomt2"
      },
      {
        "slug": "popdc2",
        "symbol": "POPDC2",
        "hgnc": "HGNC:17648",
        "name": "popeye domain cAMP effector 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/popdc2"
      },
      {
        "slug": "sgcg",
        "symbol": "SGCG",
        "hgnc": "HGNC:10809",
        "name": "sarcoglycan gamma",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sgcg"
      },
      {
        "slug": "zmpste24",
        "symbol": "ZMPSTE24",
        "hgnc": "HGNC:12877",
        "name": "zinc metallopeptidase STE24",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/zmpste24"
      }
    ]
  }
}