{
  "url": "https://dantelabs.com/traits/increased-circulating-t4-concentration",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "increased-circulating-t4-concentration",
    "id": "HP:0031506",
    "name": "Increased circulating T4 concentration",
    "definition": "An elevation above the normal concentration of thyroxine in the blood. Thyroxine (also known as T4) is the main hormone secreted by the thyroid gland into the blood. It can be converted into the active form triiodothyronine (also known as T3).",
    "synonyms": [
      "Increased circulating T4 level",
      "Increased circulating thyroxine level"
    ],
    "systems": [
      {
        "slug": "abnormality-of-the-endocrine-system",
        "name": "Abnormality of the endocrine system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-endocrine-system"
      }
    ],
    "broader": [
      {
        "slug": "abnormal-circulating-t4-concentration",
        "name": "Abnormal circulating T4 concentration",
        "url": "https://dantelabs.com/traits/abnormal-circulating-t4-concentration"
      }
    ],
    "narrower": [],
    "genes": [
      {
        "slug": "kcnj18",
        "symbol": "KCNJ18",
        "hgnc": "HGNC:39080",
        "name": "potassium inwardly rectifying channel subfamily J member 18",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/kcnj18"
      },
      {
        "slug": "secisbp2",
        "symbol": "SECISBP2",
        "hgnc": "HGNC:30972",
        "name": "SECIS binding protein 2",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/secisbp2"
      },
      {
        "slug": "thrb",
        "symbol": "THRB",
        "hgnc": "HGNC:11799",
        "name": "thyroid hormone receptor beta",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/thrb"
      },
      {
        "slug": "tshr",
        "symbol": "TSHR",
        "hgnc": "HGNC:12373",
        "name": "thyroid stimulating hormone receptor",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/tshr"
      }
    ]
  }
}