{
  "url": "https://dantelabs.com/traits/hypoplastic-spleen",
  "trait": {
    "bundleId": "2026.10.19-9814e911",
    "release": "2026-09-01",
    "slug": "hypoplastic-spleen",
    "id": "HP:0006270",
    "name": "Underdeveloped spleen",
    "label": "Hypoplastic spleen",
    "definition": "Underdevelopment of the spleen.",
    "synonyms": [],
    "systems": [
      {
        "slug": "abnormality-of-the-cardiovascular-system",
        "name": "Abnormality of the cardiovascular system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-cardiovascular-system"
      },
      {
        "slug": "abnormality-of-the-digestive-system",
        "name": "Abnormality of the digestive system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-digestive-system"
      },
      {
        "slug": "abnormality-of-the-immune-system",
        "name": "Abnormality of the immune system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-immune-system"
      }
    ],
    "broader": [
      {
        "slug": "aplasia-hypoplasia-of-the-spleen",
        "name": "Absent/small spleen",
        "url": "https://dantelabs.com/traits/aplasia-hypoplasia-of-the-spleen"
      }
    ],
    "narrower": [],
    "genes": [
      {
        "slug": "mcm10",
        "symbol": "MCM10",
        "hgnc": "HGNC:18043",
        "name": "minichromosome maintenance 10 replication initiation factor",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mcm10"
      },
      {
        "slug": "clxn",
        "symbol": "CLXN",
        "hgnc": "HGNC:25678",
        "name": "calaxin",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/clxn"
      },
      {
        "slug": "stim1",
        "symbol": "STIM1",
        "hgnc": "HGNC:11386",
        "name": "stromal interaction molecule 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/stim1"
      },
      {
        "slug": "aire",
        "symbol": "AIRE",
        "hgnc": "HGNC:360",
        "name": "autoimmune regulator",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/aire"
      },
      {
        "slug": "hmox1",
        "symbol": "HMOX1",
        "hgnc": "HGNC:5013",
        "name": "heme oxygenase 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hmox1"
      },
      {
        "slug": "katnb1",
        "symbol": "KATNB1",
        "hgnc": "HGNC:6217",
        "name": "katanin regulatory subunit B1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/katnb1"
      },
      {
        "slug": "nde1",
        "symbol": "NDE1",
        "hgnc": "HGNC:17619",
        "name": "nudE neurodevelopment protein 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nde1"
      },
      {
        "slug": "reln",
        "symbol": "RELN",
        "hgnc": "HGNC:9957",
        "name": "reelin",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/reln"
      },
      {
        "slug": "samd9",
        "symbol": "SAMD9",
        "hgnc": "HGNC:1348",
        "name": "sterile alpha motif domain containing 9",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/samd9"
      },
      {
        "slug": "fam111a",
        "symbol": "FAM111A",
        "hgnc": "HGNC:24725",
        "name": "FAM111 trypsin like peptidase A",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fam111a"
      },
      {
        "slug": "stra6",
        "symbol": "STRA6",
        "hgnc": "HGNC:30650",
        "name": "signaling receptor and transporter of retinol STRA6",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/stra6"
      }
    ]
  }
}