{
  "url": "https://dantelabs.com/traits/hypoparathyroidism",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "hypoparathyroidism",
    "id": "HP:0000829",
    "name": "Decreased parathyroid hormone secretion",
    "label": "Hypoparathyroidism",
    "definition": "A condition caused by a deficiency of parathyroid hormone characterized by hypocalcemia and hyperphosphatemia.",
    "synonyms": [
      "Low parathyroid hormone"
    ],
    "systems": [
      {
        "slug": "abnormality-of-the-endocrine-system",
        "name": "Abnormality of the endocrine system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-endocrine-system"
      }
    ],
    "broader": [
      {
        "slug": "abnormality-of-the-parathyroid-physiology",
        "name": "Parathyroid dysfunction",
        "url": "https://dantelabs.com/traits/abnormality-of-the-parathyroid-physiology"
      }
    ],
    "narrower": [
      {
        "slug": "congenital-hypoparathyroidism",
        "name": "Congenital hypoparathyroidism",
        "genes": 3,
        "url": "https://dantelabs.com/traits/congenital-hypoparathyroidism"
      },
      {
        "slug": "autoimmune-hypoparathyroidism",
        "name": "Autoimmune hypoparathyroidism",
        "genes": 1,
        "url": "https://dantelabs.com/traits/autoimmune-hypoparathyroidism"
      }
    ],
    "genes": [
      {
        "slug": "gata3",
        "symbol": "GATA3",
        "hgnc": "HGNC:4172",
        "name": "GATA binding protein 3",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/gata3"
      },
      {
        "slug": "kdm6a",
        "symbol": "KDM6A",
        "hgnc": "HGNC:12637",
        "name": "lysine demethylase 6A",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/kdm6a"
      },
      {
        "slug": "kmt2d",
        "symbol": "KMT2D",
        "hgnc": "HGNC:7133",
        "name": "lysine methyltransferase 2D",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/kmt2d"
      },
      {
        "slug": "pth",
        "symbol": "PTH",
        "hgnc": "HGNC:9606",
        "name": "parathyroid hormone",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pth"
      },
      {
        "slug": "aire",
        "symbol": "AIRE",
        "hgnc": "HGNC:360",
        "name": "autoimmune regulator",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/aire"
      },
      {
        "slug": "tbce",
        "symbol": "TBCE",
        "hgnc": "HGNC:11582",
        "name": "tubulin folding cofactor E",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/tbce"
      },
      {
        "slug": "arvcf",
        "symbol": "ARVCF",
        "hgnc": "HGNC:728",
        "name": "ARVCF delta catenin family member",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/arvcf"
      },
      {
        "slug": "chd7",
        "symbol": "CHD7",
        "hgnc": "HGNC:20626",
        "name": "chromodomain helicase DNA binding protein 7",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/chd7"
      },
      {
        "slug": "comt",
        "symbol": "COMT",
        "hgnc": "HGNC:2228",
        "name": "catechol-O-methyltransferase",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/comt"
      },
      {
        "slug": "gp1bb",
        "symbol": "GP1BB",
        "hgnc": "HGNC:4440",
        "name": "glycoprotein Ib platelet subunit beta",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gp1bb"
      },
      {
        "slug": "hira",
        "symbol": "HIRA",
        "hgnc": "HGNC:4916",
        "name": "histone cell cycle regulator",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hira"
      },
      {
        "slug": "irx5",
        "symbol": "IRX5",
        "hgnc": "HGNC:14361",
        "name": "iroquois homeobox 5",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/irx5"
      },
      {
        "slug": "jmjd1c",
        "symbol": "JMJD1C",
        "hgnc": "HGNC:12313",
        "name": "jumonji domain containing 1C",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/jmjd1c"
      },
      {
        "slug": "rreb1",
        "symbol": "RREB1",
        "hgnc": "HGNC:10449",
        "name": "ras responsive element binding protein 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rreb1"
      },
      {
        "slug": "sec24c",
        "symbol": "SEC24C",
        "hgnc": "HGNC:10705",
        "name": "SEC24 homolog C, COPII component",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sec24c"
      },
      {
        "slug": "tbx1",
        "symbol": "TBX1",
        "hgnc": "HGNC:11592",
        "name": "T-box transcription factor 1",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/tbx1"
      },
      {
        "slug": "ufd1",
        "symbol": "UFD1",
        "hgnc": "HGNC:12520",
        "name": "ubiquitin recognition factor in ER associated degradation 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ufd1"
      },
      {
        "slug": "atp7b",
        "symbol": "ATP7B",
        "hgnc": "HGNC:870",
        "name": "ATPase copper transporting beta",
        "frequency": "occasional",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/atp7b"
      },
      {
        "slug": "dgcr2",
        "symbol": "DGCR2",
        "hgnc": "HGNC:2845",
        "name": "DiGeorge syndrome critical region gene 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dgcr2"
      },
      {
        "slug": "dgcr6",
        "symbol": "DGCR6",
        "hgnc": "HGNC:2846",
        "name": "DiGeorge syndrome critical region gene 6",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dgcr6"
      },
      {
        "slug": "dgcr8",
        "symbol": "DGCR8",
        "hgnc": "HGNC:2847",
        "name": "DGCR8 microprocessor complex subunit",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dgcr8"
      },
      {
        "slug": "ess2",
        "symbol": "ESS2",
        "hgnc": "HGNC:16817",
        "name": "ess-2 spliceosome associated protein",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ess2"
      },
      {
        "slug": "hadha",
        "symbol": "HADHA",
        "hgnc": "HGNC:4801",
        "name": "hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hadha"
      },
      {
        "slug": "hadhb",
        "symbol": "HADHB",
        "hgnc": "HGNC:4803",
        "name": "hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hadhb"
      },
      {
        "slug": "hbb",
        "symbol": "HBB",
        "hgnc": "HGNC:4827",
        "name": "hemoglobin subunit beta",
        "frequency": "occasional",
        "diseases": 3,
        "url": "https://dantelabs.com/genes/hbb"
      },
      {
        "slug": "mpv17",
        "symbol": "MPV17",
        "hgnc": "HGNC:7224",
        "name": "mitochondrial inner membrane protein MPV17",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mpv17"
      },
      {
        "slug": "mt-atp8",
        "symbol": "MT-ATP8",
        "hgnc": "HGNC:7415",
        "name": "mitochondrially encoded ATP synthase membrane subunit 8",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mt-atp8"
      },
      {
        "slug": "mt-tl1",
        "symbol": "MT-TL1",
        "hgnc": "HGNC:7490",
        "name": "mitochondrially encoded tRNA-Leu (UUA/G) 1",
        "frequency": "occasional",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/mt-tl1"
      },
      {
        "slug": "pigt",
        "symbol": "PIGT",
        "hgnc": "HGNC:14938",
        "name": "phosphatidylinositol glycan anchor biosynthesis class T",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pigt"
      },
      {
        "slug": "rrm2b",
        "symbol": "RRM2B",
        "hgnc": "HGNC:17296",
        "name": "ribonucleotide reductase regulatory TP53 inducible subunit M2B",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rrm2b"
      },
      {
        "slug": "tbx2",
        "symbol": "TBX2",
        "hgnc": "HGNC:11597",
        "name": "T-box transcription factor 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tbx2"
      },
      {
        "slug": "mt-co1",
        "symbol": "MT-CO1",
        "hgnc": "HGNC:7419",
        "name": "mitochondrially encoded cytochrome c oxidase I",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mt-co1"
      },
      {
        "slug": "mt-co2",
        "symbol": "MT-CO2",
        "hgnc": "HGNC:7421",
        "name": "mitochondrially encoded cytochrome c oxidase II",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mt-co2"
      },
      {
        "slug": "mt-co3",
        "symbol": "MT-CO3",
        "hgnc": "HGNC:7422",
        "name": "mitochondrially encoded cytochrome c oxidase III",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mt-co3"
      },
      {
        "slug": "mt-nd1",
        "symbol": "MT-ND1",
        "hgnc": "HGNC:7455",
        "name": "mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 1",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mt-nd1"
      },
      {
        "slug": "mt-nd4",
        "symbol": "MT-ND4",
        "hgnc": "HGNC:7459",
        "name": "mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 4",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mt-nd4"
      },
      {
        "slug": "mt-nd5",
        "symbol": "MT-ND5",
        "hgnc": "HGNC:7461",
        "name": "mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 5",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mt-nd5"
      },
      {
        "slug": "mt-nd6",
        "symbol": "MT-ND6",
        "hgnc": "HGNC:7462",
        "name": "mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 6",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mt-nd6"
      },
      {
        "slug": "mt-tf",
        "symbol": "MT-TF",
        "hgnc": "HGNC:7481",
        "name": "mitochondrially encoded tRNA-Phe (UUU/C)",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mt-tf"
      },
      {
        "slug": "mt-th",
        "symbol": "MT-TH",
        "hgnc": "HGNC:7487",
        "name": "mitochondrially encoded tRNA-His (CAU/C)",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mt-th"
      },
      {
        "slug": "mt-tq",
        "symbol": "MT-TQ",
        "hgnc": "HGNC:7495",
        "name": "mitochondrially encoded tRNA-Gln (CAA/G)",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mt-tq"
      },
      {
        "slug": "mt-ts1",
        "symbol": "MT-TS1",
        "hgnc": "HGNC:7497",
        "name": "mitochondrially encoded tRNA-Ser (UCN) 1",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mt-ts1"
      },
      {
        "slug": "mt-ts2",
        "symbol": "MT-TS2",
        "hgnc": "HGNC:7498",
        "name": "mitochondrially encoded tRNA-Ser (AGU/C) 2",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mt-ts2"
      },
      {
        "slug": "mt-tw",
        "symbol": "MT-TW",
        "hgnc": "HGNC:7501",
        "name": "mitochondrially encoded tRNA-Trp (UGA/G)",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mt-tw"
      },
      {
        "slug": "nkx2-1",
        "symbol": "NKX2-1",
        "hgnc": "HGNC:11825",
        "name": "NK2 homeobox 1",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nkx2-1"
      },
      {
        "slug": "col4a3",
        "symbol": "COL4A3",
        "hgnc": "HGNC:2204",
        "name": "collagen type IV alpha 3 chain",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/col4a3"
      },
      {
        "slug": "col4a4",
        "symbol": "COL4A4",
        "hgnc": "HGNC:2206",
        "name": "collagen type IV alpha 4 chain",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/col4a4"
      },
      {
        "slug": "col4a5",
        "symbol": "COL4A5",
        "hgnc": "HGNC:2207",
        "name": "collagen type IV alpha 5 chain",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/col4a5"
      },
      {
        "slug": "fam111a",
        "symbol": "FAM111A",
        "hgnc": "HGNC:24725",
        "name": "FAM111 trypsin like peptidase A",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fam111a"
      },
      {
        "slug": "pth1r",
        "symbol": "PTH1R",
        "hgnc": "HGNC:9608",
        "name": "parathyroid hormone 1 receptor",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pth1r"
      }
    ]
  }
}