{
  "url": "https://dantelabs.com/traits/glomerulonephritis",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "glomerulonephritis",
    "id": "HP:0000099",
    "name": "Glomerulonephritis",
    "definition": "Inflammation of the renal glomeruli.",
    "synonyms": [
      "Glomerular nephritis"
    ],
    "systems": [
      {
        "slug": "abnormality-of-the-genitourinary-system",
        "name": "Abnormality of the genitourinary system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-genitourinary-system"
      },
      {
        "slug": "abnormality-of-the-immune-system",
        "name": "Abnormality of the immune system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-immune-system"
      }
    ],
    "broader": [
      {
        "slug": "abnormal-renal-glomerulus-morphology",
        "name": "Abnormal renal glomerulus morphology",
        "url": "https://dantelabs.com/traits/abnormal-renal-glomerulus-morphology"
      },
      {
        "slug": "nephritis",
        "name": "Kidney inflammation",
        "url": "https://dantelabs.com/traits/nephritis"
      }
    ],
    "narrower": [
      {
        "slug": "minimal-change-glomerulonephritis",
        "name": "Minimal change glomerulonephritis",
        "genes": 40,
        "url": "https://dantelabs.com/traits/minimal-change-glomerulonephritis"
      },
      {
        "slug": "lupus-nephritis",
        "name": "Lupus nephritis",
        "genes": 33,
        "url": "https://dantelabs.com/traits/lupus-nephritis"
      },
      {
        "slug": "membranoproliferative-glomerulonephritis",
        "name": "Membranoproliferative glomerulonephritis",
        "genes": 9,
        "url": "https://dantelabs.com/traits/membranoproliferative-glomerulonephritis"
      },
      {
        "slug": "membranous-nephropathy",
        "name": "Membranous nephropathy",
        "genes": 4,
        "url": "https://dantelabs.com/traits/membranous-nephropathy"
      },
      {
        "slug": "crescentic-glomerulonephritis",
        "name": "Crescentic glomerulonephritis",
        "genes": 1,
        "url": "https://dantelabs.com/traits/crescentic-glomerulonephritis"
      }
    ],
    "genes": [
      {
        "slug": "cd81",
        "symbol": "CD81",
        "hgnc": "HGNC:1701",
        "name": "CD81 molecule",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cd81"
      },
      {
        "slug": "lamb2",
        "symbol": "LAMB2",
        "hgnc": "HGNC:6487",
        "name": "laminin subunit beta 2",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lamb2"
      },
      {
        "slug": "oas2",
        "symbol": "OAS2",
        "hgnc": "HGNC:8087",
        "name": "2'-5'-oligoadenylate synthetase 2",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/oas2"
      },
      {
        "slug": "tapbp",
        "symbol": "TAPBP",
        "hgnc": "HGNC:11566",
        "name": "TAP binding protein",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tapbp"
      },
      {
        "slug": "wdr19",
        "symbol": "WDR19",
        "hgnc": "HGNC:18340",
        "name": "WD repeat domain 19",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/wdr19"
      },
      {
        "slug": "mme",
        "symbol": "MME",
        "hgnc": "HGNC:7154",
        "name": "membrane metalloendopeptidase",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mme"
      },
      {
        "slug": "ctla4",
        "symbol": "CTLA4",
        "hgnc": "HGNC:2505",
        "name": "cytotoxic T-lymphocyte associated protein 4",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ctla4"
      },
      {
        "slug": "hla-dpa1",
        "symbol": "HLA-DPA1",
        "hgnc": "HGNC:4938",
        "name": "major histocompatibility complex, class II, DP alpha 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hla-dpa1"
      },
      {
        "slug": "hla-dpb1",
        "symbol": "HLA-DPB1",
        "hgnc": "HGNC:4940",
        "name": "major histocompatibility complex, class II, DP beta 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hla-dpb1"
      },
      {
        "slug": "prtn3",
        "symbol": "PRTN3",
        "hgnc": "HGNC:9495",
        "name": "proteinase 3",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/prtn3"
      },
      {
        "slug": "ptpn22",
        "symbol": "PTPN22",
        "hgnc": "HGNC:9652",
        "name": "protein tyrosine phosphatase non-receptor type 22",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ptpn22"
      },
      {
        "slug": "slc7a7",
        "symbol": "SLC7A7",
        "hgnc": "HGNC:11065",
        "name": "solute carrier family 7 member 7",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slc7a7"
      },
      {
        "slug": "alms1",
        "symbol": "ALMS1",
        "hgnc": "HGNC:428",
        "name": "ALMS1 centrosome and basal body associated protein",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/alms1"
      },
      {
        "slug": "casp10",
        "symbol": "CASP10",
        "hgnc": "HGNC:1500",
        "name": "caspase 10",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/casp10"
      },
      {
        "slug": "col7a1",
        "symbol": "COL7A1",
        "hgnc": "HGNC:2214",
        "name": "collagen type VII alpha 1 chain",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/col7a1"
      },
      {
        "slug": "fas",
        "symbol": "FAS",
        "hgnc": "HGNC:11920",
        "name": "Fas cell surface death receptor",
        "frequency": "occasional",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/fas"
      },
      {
        "slug": "faslg",
        "symbol": "FASLG",
        "hgnc": "HGNC:11936",
        "name": "Fas ligand",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/faslg"
      },
      {
        "slug": "foxp3",
        "symbol": "FOXP3",
        "hgnc": "HGNC:6106",
        "name": "forkhead box P3",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/foxp3"
      },
      {
        "slug": "hla-drb1",
        "symbol": "HLA-DRB1",
        "hgnc": "HGNC:4948",
        "name": "major histocompatibility complex, class II, DR beta 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hla-drb1"
      },
      {
        "slug": "il6",
        "symbol": "IL6",
        "hgnc": "HGNC:6018",
        "name": "interleukin 6",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/il6"
      },
      {
        "slug": "lacc1",
        "symbol": "LACC1",
        "hgnc": "HGNC:26789",
        "name": "laccase domain multifunctional purine nucleosidase 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lacc1"
      },
      {
        "slug": "mif",
        "symbol": "MIF",
        "hgnc": "HGNC:7097",
        "name": "macrophage migration inhibitory factor",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mif"
      },
      {
        "slug": "mmp1",
        "symbol": "MMP1",
        "hgnc": "HGNC:7155",
        "name": "matrix metallopeptidase 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mmp1"
      },
      {
        "slug": "socs1",
        "symbol": "SOCS1",
        "hgnc": "HGNC:19383",
        "name": "suppressor of cytokine signaling 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/socs1"
      },
      {
        "slug": "trim8",
        "symbol": "TRIM8",
        "hgnc": "HGNC:15579",
        "name": "tripartite motif containing 8",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/trim8"
      },
      {
        "slug": "c4a",
        "symbol": "C4A",
        "hgnc": "HGNC:1323",
        "name": "complement C4A (Chido/Rodgers blood group)",
        "frequency": "very-rare",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/c4a"
      },
      {
        "slug": "ccr1",
        "symbol": "CCR1",
        "hgnc": "HGNC:1602",
        "name": "C-C motif chemokine receptor 1",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ccr1"
      },
      {
        "slug": "erap1",
        "symbol": "ERAP1",
        "hgnc": "HGNC:18173",
        "name": "endoplasmic reticulum aminopeptidase 1",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/erap1"
      },
      {
        "slug": "hla-b",
        "symbol": "HLA-B",
        "hgnc": "HGNC:4932",
        "name": "major histocompatibility complex, class I, B",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hla-b"
      },
      {
        "slug": "ifngr1",
        "symbol": "IFNGR1",
        "hgnc": "HGNC:5439",
        "name": "interferon gamma receptor 1",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ifngr1"
      },
      {
        "slug": "il10",
        "symbol": "IL10",
        "hgnc": "HGNC:5962",
        "name": "interleukin 10",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/il10"
      },
      {
        "slug": "il12a",
        "symbol": "IL12A",
        "hgnc": "HGNC:5969",
        "name": "interleukin 12A",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/il12a"
      },
      {
        "slug": "il12a-as1",
        "symbol": "IL12A-AS1",
        "hgnc": "HGNC:49094",
        "name": "IL12A antisense RNA 1",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/il12a-as1"
      },
      {
        "slug": "il23r",
        "symbol": "IL23R",
        "hgnc": "HGNC:19100",
        "name": "interleukin 23 receptor",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/il23r"
      },
      {
        "slug": "klrc4",
        "symbol": "KLRC4",
        "hgnc": "HGNC:6377",
        "name": "killer cell lectin like receptor C4",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/klrc4"
      },
      {
        "slug": "mefv",
        "symbol": "MEFV",
        "hgnc": "HGNC:6998",
        "name": "MEFV innate immunity regulator, pyrin",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mefv"
      },
      {
        "slug": "stat4",
        "symbol": "STAT4",
        "hgnc": "HGNC:11365",
        "name": "signal transducer and activator of transcription 4",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/stat4"
      },
      {
        "slug": "tlr4",
        "symbol": "TLR4",
        "hgnc": "HGNC:11850",
        "name": "toll like receptor 4",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tlr4"
      },
      {
        "slug": "ubac2",
        "symbol": "UBAC2",
        "hgnc": "HGNC:20486",
        "name": "UBA domain containing 2",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ubac2"
      },
      {
        "slug": "cfhr5",
        "symbol": "CFHR5",
        "hgnc": "HGNC:24668",
        "name": "complement factor H related 5",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cfhr5"
      },
      {
        "slug": "cfi",
        "symbol": "CFI",
        "hgnc": "HGNC:5394",
        "name": "complement factor I",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cfi"
      },
      {
        "slug": "col4a3",
        "symbol": "COL4A3",
        "hgnc": "HGNC:2204",
        "name": "collagen type IV alpha 3 chain",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/col4a3"
      },
      {
        "slug": "lmx1b",
        "symbol": "LMX1B",
        "hgnc": "HGNC:6654",
        "name": "LIM homeobox transcription factor 1 beta",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lmx1b"
      }
    ]
  }
}