{
  "url": "https://dantelabs.com/traits/frontotemporal-dementia",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "frontotemporal-dementia",
    "id": "HP:0002145",
    "name": "Frontotemporal dementia",
    "definition": "A dementia associated with degeneration of the frontotemporal lobe and clinically associated with personality and behavioral changes such as disinhibition, apathy, and lack of insight. The hallmark feature of frontotemporal dementia is the presentation with focal syndromes such as progressive language dysfunction, or aphasia, or behavioral changes characteristic of frontal lobe disorders.",
    "synonyms": [],
    "systems": [
      {
        "slug": "abnormality-of-the-nervous-system",
        "name": "Abnormality of the nervous system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-nervous-system"
      }
    ],
    "broader": [
      {
        "slug": "dementia",
        "name": "Dementia",
        "url": "https://dantelabs.com/traits/dementia"
      }
    ],
    "narrower": [
      {
        "slug": "semantic-dementia",
        "name": "Trouble remembering words",
        "genes": 6,
        "url": "https://dantelabs.com/traits/semantic-dementia"
      }
    ],
    "genes": [
      {
        "slug": "chchd10",
        "symbol": "CHCHD10",
        "hgnc": "HGNC:15559",
        "name": "coiled-coil-helix-coiled-coil-helix domain containing 10",
        "frequency": "obligate",
        "diseases": 3,
        "url": "https://dantelabs.com/genes/chchd10"
      },
      {
        "slug": "chmp2b",
        "symbol": "CHMP2B",
        "hgnc": "HGNC:24537",
        "name": "charged multivesicular body protein 2B",
        "frequency": "very-frequent",
        "diseases": 4,
        "url": "https://dantelabs.com/genes/chmp2b"
      },
      {
        "slug": "fus",
        "symbol": "FUS",
        "hgnc": "HGNC:4010",
        "name": "FUS RNA binding protein",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/fus"
      },
      {
        "slug": "grn",
        "symbol": "GRN",
        "hgnc": "HGNC:4601",
        "name": "granulin precursor",
        "frequency": "very-frequent",
        "diseases": 3,
        "url": "https://dantelabs.com/genes/grn"
      },
      {
        "slug": "mapt",
        "symbol": "MAPT",
        "hgnc": "HGNC:6893",
        "name": "microtubule associated protein tau",
        "frequency": "very-frequent",
        "diseases": 4,
        "url": "https://dantelabs.com/genes/mapt"
      },
      {
        "slug": "prkar1b",
        "symbol": "PRKAR1B",
        "hgnc": "HGNC:9390",
        "name": "protein kinase cAMP-dependent type I regulatory subunit beta",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/prkar1b"
      },
      {
        "slug": "psen1",
        "symbol": "PSEN1",
        "hgnc": "HGNC:9508",
        "name": "presenilin 1",
        "frequency": "very-frequent",
        "diseases": 4,
        "url": "https://dantelabs.com/genes/psen1"
      },
      {
        "slug": "sqstm1",
        "symbol": "SQSTM1",
        "hgnc": "HGNC:11280",
        "name": "sequestosome 1",
        "frequency": "very-frequent",
        "diseases": 4,
        "url": "https://dantelabs.com/genes/sqstm1"
      },
      {
        "slug": "tardbp",
        "symbol": "TARDBP",
        "hgnc": "HGNC:11571",
        "name": "TAR DNA binding protein",
        "frequency": "very-frequent",
        "diseases": 3,
        "url": "https://dantelabs.com/genes/tardbp"
      },
      {
        "slug": "tbk1",
        "symbol": "TBK1",
        "hgnc": "HGNC:11584",
        "name": "TANK binding kinase 1",
        "frequency": "very-frequent",
        "diseases": 3,
        "url": "https://dantelabs.com/genes/tbk1"
      },
      {
        "slug": "tmem106b",
        "symbol": "TMEM106B",
        "hgnc": "HGNC:22407",
        "name": "transmembrane protein 106B",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/tmem106b"
      },
      {
        "slug": "trem2",
        "symbol": "TREM2",
        "hgnc": "HGNC:17761",
        "name": "triggering receptor expressed on myeloid cells 2",
        "frequency": "very-frequent",
        "diseases": 3,
        "url": "https://dantelabs.com/genes/trem2"
      },
      {
        "slug": "vcp",
        "symbol": "VCP",
        "hgnc": "HGNC:12666",
        "name": "valosin containing protein",
        "frequency": "very-frequent",
        "diseases": 6,
        "url": "https://dantelabs.com/genes/vcp"
      },
      {
        "slug": "hnrnpa1",
        "symbol": "HNRNPA1",
        "hgnc": "HGNC:5031",
        "name": "heterogeneous nuclear ribonucleoprotein A1",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/hnrnpa1"
      },
      {
        "slug": "hnrnpa2b1",
        "symbol": "HNRNPA2B1",
        "hgnc": "HGNC:5033",
        "name": "heterogeneous nuclear ribonucleoprotein A2/B1",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/hnrnpa2b1"
      },
      {
        "slug": "pla2g6",
        "symbol": "PLA2G6",
        "hgnc": "HGNC:9039",
        "name": "phospholipase A2 group VI",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/pla2g6"
      },
      {
        "slug": "tia1",
        "symbol": "TIA1",
        "hgnc": "HGNC:11802",
        "name": "TIA1 cytotoxic granule associated RNA binding protein",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tia1"
      },
      {
        "slug": "ang",
        "symbol": "ANG",
        "hgnc": "HGNC:483",
        "name": "angiogenin",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ang"
      },
      {
        "slug": "anxa11",
        "symbol": "ANXA11",
        "hgnc": "HGNC:535",
        "name": "annexin A11",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/anxa11"
      },
      {
        "slug": "atxn2",
        "symbol": "ATXN2",
        "hgnc": "HGNC:10555",
        "name": "ataxin 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/atxn2"
      },
      {
        "slug": "ccnf",
        "symbol": "CCNF",
        "hgnc": "HGNC:1591",
        "name": "cyclin F",
        "frequency": "occasional",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/ccnf"
      },
      {
        "slug": "cfap410",
        "symbol": "CFAP410",
        "hgnc": "HGNC:1260",
        "name": "cilia and flagella associated protein 410",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cfap410"
      },
      {
        "slug": "dao",
        "symbol": "DAO",
        "hgnc": "HGNC:2671",
        "name": "D-amino acid oxidase",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dao"
      },
      {
        "slug": "dctn1",
        "symbol": "DCTN1",
        "hgnc": "HGNC:2711",
        "name": "dynactin subunit 1",
        "frequency": "occasional",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/dctn1"
      },
      {
        "slug": "erbb4",
        "symbol": "ERBB4",
        "hgnc": "HGNC:3432",
        "name": "erb-b2 receptor tyrosine kinase 4",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/erbb4"
      },
      {
        "slug": "fig4",
        "symbol": "FIG4",
        "hgnc": "HGNC:16873",
        "name": "FIG4 phosphoinositide 5-phosphatase",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fig4"
      },
      {
        "slug": "gle1",
        "symbol": "GLE1",
        "hgnc": "HGNC:4315",
        "name": "GLE1 RNA export mediator",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gle1"
      },
      {
        "slug": "glt8d1",
        "symbol": "GLT8D1",
        "hgnc": "HGNC:24870",
        "name": "glycosyltransferase 8 domain containing 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/glt8d1"
      },
      {
        "slug": "lrp12",
        "symbol": "LRP12",
        "hgnc": "HGNC:31708",
        "name": "LDL receptor related protein 12",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lrp12"
      },
      {
        "slug": "matr3",
        "symbol": "MATR3",
        "hgnc": "HGNC:6912",
        "name": "matrin 3",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/matr3"
      },
      {
        "slug": "nefh",
        "symbol": "NEFH",
        "hgnc": "HGNC:7737",
        "name": "neurofilament heavy chain",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nefh"
      },
      {
        "slug": "nek1",
        "symbol": "NEK1",
        "hgnc": "HGNC:7744",
        "name": "NIMA related kinase 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nek1"
      },
      {
        "slug": "optn",
        "symbol": "OPTN",
        "hgnc": "HGNC:17142",
        "name": "optineurin",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/optn"
      },
      {
        "slug": "pfn1",
        "symbol": "PFN1",
        "hgnc": "HGNC:8881",
        "name": "profilin 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pfn1"
      },
      {
        "slug": "prph",
        "symbol": "PRPH",
        "hgnc": "HGNC:9461",
        "name": "peripherin",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/prph"
      },
      {
        "slug": "sod1",
        "symbol": "SOD1",
        "hgnc": "HGNC:11179",
        "name": "superoxide dismutase 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sod1"
      },
      {
        "slug": "taf15",
        "symbol": "TAF15",
        "hgnc": "HGNC:11547",
        "name": "TATA-box binding protein associated factor 15",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/taf15"
      },
      {
        "slug": "tuba4a",
        "symbol": "TUBA4A",
        "hgnc": "HGNC:12407",
        "name": "tubulin alpha 4a",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tuba4a"
      },
      {
        "slug": "ubqln2",
        "symbol": "UBQLN2",
        "hgnc": "HGNC:12509",
        "name": "ubiquilin 2",
        "frequency": "occasional",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/ubqln2"
      },
      {
        "slug": "unc13a",
        "symbol": "UNC13A",
        "hgnc": "HGNC:23150",
        "name": "unc-13 homolog A",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/unc13a"
      },
      {
        "slug": "vapb",
        "symbol": "VAPB",
        "hgnc": "HGNC:12649",
        "name": "VAMP associated protein B and C",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/vapb"
      },
      {
        "slug": "zfyve26",
        "symbol": "ZFYVE26",
        "hgnc": "HGNC:20761",
        "name": "zinc finger FYVE-type containing 26",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/zfyve26"
      },
      {
        "slug": "c9orf72",
        "symbol": "C9orf72",
        "hgnc": "HGNC:28337",
        "name": "C9orf72-SMCR8 complex subunit",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/c9orf72"
      },
      {
        "slug": "cyld",
        "symbol": "CYLD",
        "hgnc": "HGNC:2584",
        "name": "CYLD lysine 63 deubiquitinase",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cyld"
      }
    ]
  }
}