{
  "url": "https://dantelabs.com/traits/flexural-reticulate-hyperpigmentation",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "flexural-reticulate-hyperpigmentation",
    "id": "HP:6000745",
    "name": "Flexural reticulate hyperpigmentation",
    "definition": "Hyperpigmented macules with a reticulate (net-like) pattern involving the neck, axillae, groins, and other flexures like the inframammary folds in females. Histopathology shows orthokeratosis or hyperkeratosis, thinning of the suprapapillary epithelium, elongation of the rete ridges, hyperpigmentation of the basal layer, and follicular cysts. A perivascular lymphohistiocytic infiltrate can be observed in the papillary dermis.",
    "synonyms": [
      "Reticular pigmented anomaly of the flexures",
      "Reticulate hyperpigmentation of the flexures"
    ],
    "systems": [
      {
        "slug": "abnormality-of-the-integument",
        "name": "Abnormality of the integument",
        "url": "https://dantelabs.com/traits/abnormality-of-the-integument"
      }
    ],
    "broader": [
      {
        "slug": "reticulated-skin-pigmentation",
        "name": "Reticulated skin pigmentation",
        "url": "https://dantelabs.com/traits/reticulated-skin-pigmentation"
      }
    ],
    "narrower": [],
    "genes": [
      {
        "slug": "rbm28",
        "symbol": "RBM28",
        "hgnc": "HGNC:21863",
        "name": "RNA binding motif protein 28",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rbm28"
      }
    ]
  }
}