{
  "url": "https://dantelabs.com/traits/erythroid-hyperplasia",
  "trait": {
    "bundleId": "2026.10.19-9814e911",
    "release": "2026-09-01",
    "slug": "erythroid-hyperplasia",
    "id": "HP:0012132",
    "name": "Erythroid hyperplasia",
    "definition": "Increased count of erythroid precursor cells, that is, erythroid lineage cells in the bone marrow.",
    "synonyms": [],
    "systems": [
      {
        "slug": "abnormality-of-blood-and-blood-forming-tissues",
        "name": "Abnormality of blood and blood-forming tissues",
        "url": "https://dantelabs.com/traits/abnormality-of-blood-and-blood-forming-tissues"
      }
    ],
    "broader": [
      {
        "slug": "abnormal-number-of-erythroid-precursors",
        "name": "Abnormal number of erythroid precursors",
        "url": "https://dantelabs.com/traits/abnormal-number-of-erythroid-precursors"
      }
    ],
    "narrower": [
      {
        "slug": "megaloblastic-erythroid-hyperplasia",
        "name": "Megaloblastic erythroid hyperplasia",
        "genes": 3,
        "url": "https://dantelabs.com/traits/megaloblastic-erythroid-hyperplasia"
      }
    ],
    "genes": [
      {
        "slug": "abcb7",
        "symbol": "ABCB7",
        "hgnc": "HGNC:48",
        "name": "ATP binding cassette subfamily B member 7",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/abcb7"
      },
      {
        "slug": "cdan1",
        "symbol": "CDAN1",
        "hgnc": "HGNC:1713",
        "name": "codanin 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cdan1"
      },
      {
        "slug": "gata1",
        "symbol": "GATA1",
        "hgnc": "HGNC:4170",
        "name": "GATA binding protein 1",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/gata1"
      },
      {
        "slug": "klf1",
        "symbol": "KLF1",
        "hgnc": "HGNC:6345",
        "name": "KLF transcription factor 1",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/klf1"
      },
      {
        "slug": "lars2",
        "symbol": "LARS2",
        "hgnc": "HGNC:17095",
        "name": "leucyl-tRNA synthetase 2, mitochondrial",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lars2"
      },
      {
        "slug": "lpin2",
        "symbol": "LPIN2",
        "hgnc": "HGNC:14450",
        "name": "lipin 2",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lpin2"
      },
      {
        "slug": "nhej1",
        "symbol": "NHEJ1",
        "hgnc": "HGNC:25737",
        "name": "non-homologous end joining factor 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nhej1"
      },
      {
        "slug": "pgk1",
        "symbol": "PGK1",
        "hgnc": "HGNC:8896",
        "name": "phosphoglycerate kinase 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pgk1"
      },
      {
        "slug": "pklr",
        "symbol": "PKLR",
        "hgnc": "HGNC:9020",
        "name": "pyruvate kinase L/R",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pklr"
      },
      {
        "slug": "slc11a2",
        "symbol": "SLC11A2",
        "hgnc": "HGNC:10908",
        "name": "solute carrier family 11 member 2",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slc11a2"
      },
      {
        "slug": "hbb",
        "symbol": "HBB",
        "hgnc": "HGNC:4827",
        "name": "hemoglobin subunit beta",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hbb"
      },
      {
        "slug": "sf3b1",
        "symbol": "SF3B1",
        "hgnc": "HGNC:10768",
        "name": "splicing factor 3b subunit 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sf3b1"
      },
      {
        "slug": "tet2",
        "symbol": "TET2",
        "hgnc": "HGNC:25941",
        "name": "tet methylcytosine dioxygenase 2",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tet2"
      },
      {
        "slug": "piga",
        "symbol": "PIGA",
        "hgnc": "HGNC:8957",
        "name": "phosphatidylinositol glycan anchor biosynthesis class A",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/piga"
      },
      {
        "slug": "urod",
        "symbol": "UROD",
        "hgnc": "HGNC:12591",
        "name": "uroporphyrinogen decarboxylase",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/urod"
      },
      {
        "slug": "uros",
        "symbol": "UROS",
        "hgnc": "HGNC:12592",
        "name": "uroporphyrinogen III synthase",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/uros"
      },
      {
        "slug": "cdin1",
        "symbol": "CDIN1",
        "hgnc": "HGNC:26929",
        "name": "CDAN1 interacting nuclease 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cdin1"
      },
      {
        "slug": "erbb3",
        "symbol": "ERBB3",
        "hgnc": "HGNC:3431",
        "name": "erb-b2 receptor tyrosine kinase 3",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/erbb3"
      },
      {
        "slug": "glrx5",
        "symbol": "GLRX5",
        "hgnc": "HGNC:20134",
        "name": "glutaredoxin 5",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/glrx5"
      },
      {
        "slug": "pus1",
        "symbol": "PUS1",
        "hgnc": "HGNC:15508",
        "name": "pseudouridine synthase 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pus1"
      }
    ]
  }
}