{
  "url": "https://dantelabs.com/traits/erythroderma",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "erythroderma",
    "id": "HP:0001019",
    "name": "Red scaly skin caused by inflammatory skin disease",
    "label": "Erythroderma",
    "definition": "An inflammatory exfoliative dermatosis involving nearly all of the surface of the skin. Erythroderma develops suddenly. A patchy erythema may generalize and spread to affect most of the skin. Scaling may appear in 2-6 days and be accompanied by hot, red, dry skin, malaise, and fever.",
    "synonyms": [
      "Exfoliative dermititis",
      "Generalised erythroderma",
      "Generalised erythrodermia",
      "Generalized erythroderma",
      "Generalized erythrodermia"
    ],
    "systems": [
      {
        "slug": "abnormality-of-the-immune-system",
        "name": "Abnormality of the immune system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-immune-system"
      },
      {
        "slug": "abnormality-of-the-integument",
        "name": "Abnormality of the integument",
        "url": "https://dantelabs.com/traits/abnormality-of-the-integument"
      }
    ],
    "broader": [
      {
        "slug": "inflammatory-abnormality-of-the-skin",
        "name": "Inflammatory abnormality of the skin",
        "url": "https://dantelabs.com/traits/inflammatory-abnormality-of-the-skin"
      }
    ],
    "narrower": [
      {
        "slug": "congenital-exfoliative-erythroderma",
        "name": "Congenital exfoliative erythroderma",
        "genes": 14,
        "url": "https://dantelabs.com/traits/congenital-exfoliative-erythroderma"
      }
    ],
    "genes": [
      {
        "slug": "adam17",
        "symbol": "ADAM17",
        "hgnc": "HGNC:195",
        "name": "ADAM metallopeptidase domain 17",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/adam17"
      },
      {
        "slug": "ak2",
        "symbol": "AK2",
        "hgnc": "HGNC:362",
        "name": "adenylate kinase 2",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ak2"
      },
      {
        "slug": "ap1b1",
        "symbol": "AP1B1",
        "hgnc": "HGNC:554",
        "name": "adaptor related protein complex 1 subunit beta 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ap1b1"
      },
      {
        "slug": "cd247",
        "symbol": "CD247",
        "hgnc": "HGNC:1677",
        "name": "CD247 molecule",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/cd247"
      },
      {
        "slug": "cdsn",
        "symbol": "CDSN",
        "hgnc": "HGNC:1802",
        "name": "corneodesmosin",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cdsn"
      },
      {
        "slug": "cers3",
        "symbol": "CERS3",
        "hgnc": "HGNC:23752",
        "name": "ceramide synthase 3",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/cers3"
      },
      {
        "slug": "dsg1",
        "symbol": "DSG1",
        "hgnc": "HGNC:3048",
        "name": "desmoglein 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dsg1"
      },
      {
        "slug": "gjb2",
        "symbol": "GJB2",
        "hgnc": "HGNC:4284",
        "name": "gap junction protein beta 2",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gjb2"
      },
      {
        "slug": "gjb3",
        "symbol": "GJB3",
        "hgnc": "HGNC:4285",
        "name": "gap junction protein beta 3",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gjb3"
      },
      {
        "slug": "il2ra",
        "symbol": "IL2RA",
        "hgnc": "HGNC:6008",
        "name": "interleukin 2 receptor subunit alpha",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/il2ra"
      },
      {
        "slug": "klk11",
        "symbol": "KLK11",
        "hgnc": "HGNC:6359",
        "name": "kallikrein related peptidase 11",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/klk11"
      },
      {
        "slug": "krt10",
        "symbol": "KRT10",
        "hgnc": "HGNC:6413",
        "name": "keratin 10",
        "frequency": "obligate",
        "diseases": 4,
        "url": "https://dantelabs.com/genes/krt10"
      },
      {
        "slug": "pnpla1",
        "symbol": "PNPLA1",
        "hgnc": "HGNC:21246",
        "name": "patatin like domain 1, omega-hydroxyceramide transacylase",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/pnpla1"
      },
      {
        "slug": "pold3",
        "symbol": "POLD3",
        "hgnc": "HGNC:20932",
        "name": "DNA polymerase delta 3, accessory subunit",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pold3"
      },
      {
        "slug": "slc27a4",
        "symbol": "SLC27A4",
        "hgnc": "HGNC:10998",
        "name": "solute carrier family 27 member 4",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slc27a4"
      },
      {
        "slug": "abca12",
        "symbol": "ABCA12",
        "hgnc": "HGNC:14637",
        "name": "ATP binding cassette subfamily A member 12",
        "frequency": "very-frequent",
        "diseases": 3,
        "url": "https://dantelabs.com/genes/abca12"
      },
      {
        "slug": "ada",
        "symbol": "ADA",
        "hgnc": "HGNC:186",
        "name": "adenosine deaminase",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ada"
      },
      {
        "slug": "alox12b",
        "symbol": "ALOX12B",
        "hgnc": "HGNC:430",
        "name": "arachidonate 12-lipoxygenase, 12R type",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/alox12b"
      },
      {
        "slug": "aloxe3",
        "symbol": "ALOXE3",
        "hgnc": "HGNC:13743",
        "name": "arachidonate epidermal lipoxygenase 3",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/aloxe3"
      },
      {
        "slug": "ap1s3",
        "symbol": "AP1S3",
        "hgnc": "HGNC:18971",
        "name": "adaptor related protein complex 1 subunit sigma 3",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ap1s3"
      },
      {
        "slug": "card14",
        "symbol": "CARD14",
        "hgnc": "HGNC:16446",
        "name": "caspase recruitment domain family member 14",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/card14"
      },
      {
        "slug": "cd28",
        "symbol": "CD28",
        "hgnc": "HGNC:1653",
        "name": "CD28 molecule",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/cd28"
      },
      {
        "slug": "chd7",
        "symbol": "CHD7",
        "hgnc": "HGNC:20626",
        "name": "chromodomain helicase DNA binding protein 7",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/chd7"
      },
      {
        "slug": "ctla4",
        "symbol": "CTLA4",
        "hgnc": "HGNC:2505",
        "name": "cytotoxic T-lymphocyte associated protein 4",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/ctla4"
      },
      {
        "slug": "dclre1c",
        "symbol": "DCLRE1C",
        "hgnc": "HGNC:17642",
        "name": "DNA cross-link repair 1C",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/dclre1c"
      },
      {
        "slug": "il2rg",
        "symbol": "IL2RG",
        "hgnc": "HGNC:6010",
        "name": "interleukin 2 receptor subunit gamma",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/il2rg"
      },
      {
        "slug": "il36rn",
        "symbol": "IL36RN",
        "hgnc": "HGNC:15561",
        "name": "interleukin 36 receptor antagonist",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/il36rn"
      },
      {
        "slug": "il7r",
        "symbol": "IL7R",
        "hgnc": "HGNC:6024",
        "name": "interleukin 7 receptor",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/il7r"
      },
      {
        "slug": "kit",
        "symbol": "KIT",
        "hgnc": "HGNC:6342",
        "name": "KIT proto-oncogene, receptor tyrosine kinase",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/kit"
      },
      {
        "slug": "krt1",
        "symbol": "KRT1",
        "hgnc": "HGNC:6412",
        "name": "keratin 1",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/krt1"
      },
      {
        "slug": "nipal4",
        "symbol": "NIPAL4",
        "hgnc": "HGNC:28018",
        "name": "NIPA like domain containing 4",
        "frequency": "very-frequent",
        "diseases": 3,
        "url": "https://dantelabs.com/genes/nipal4"
      },
      {
        "slug": "nudcd3",
        "symbol": "NUDCD3",
        "hgnc": "HGNC:22208",
        "name": "NudC domain containing 3",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nudcd3"
      },
      {
        "slug": "psmb10",
        "symbol": "PSMB10",
        "hgnc": "HGNC:9538",
        "name": "proteasome 20S subunit beta 10",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/psmb10"
      },
      {
        "slug": "rag1",
        "symbol": "RAG1",
        "hgnc": "HGNC:9831",
        "name": "recombination activating 1",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/rag1"
      },
      {
        "slug": "rag2",
        "symbol": "RAG2",
        "hgnc": "HGNC:9832",
        "name": "recombination activating 2",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/rag2"
      },
      {
        "slug": "rmrp",
        "symbol": "RMRP",
        "hgnc": "HGNC:10031",
        "name": "RNA component of mitochondrial RNA processing endoribonuclease",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rmrp"
      },
      {
        "slug": "sdr9c7",
        "symbol": "SDR9C7",
        "hgnc": "HGNC:29958",
        "name": "short chain dehydrogenase/reductase family 9C member 7",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/sdr9c7"
      },
      {
        "slug": "spink5",
        "symbol": "SPINK5",
        "hgnc": "HGNC:15464",
        "name": "serine peptidase inhibitor Kazal type 5",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/spink5"
      },
      {
        "slug": "sult2b1",
        "symbol": "SULT2B1",
        "hgnc": "HGNC:11459",
        "name": "sulfotransferase family 2B member 1",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/sult2b1"
      },
      {
        "slug": "tgm1",
        "symbol": "TGM1",
        "hgnc": "HGNC:11777",
        "name": "transglutaminase 1",
        "frequency": "very-frequent",
        "diseases": 4,
        "url": "https://dantelabs.com/genes/tgm1"
      },
      {
        "slug": "tnfrsf1b",
        "symbol": "TNFRSF1B",
        "hgnc": "HGNC:11917",
        "name": "TNF receptor superfamily member 1B",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/tnfrsf1b"
      },
      {
        "slug": "ebp",
        "symbol": "EBP",
        "hgnc": "HGNC:3133",
        "name": "EBP cholestenol delta-isomerase",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/ebp"
      },
      {
        "slug": "elovl4",
        "symbol": "ELOVL4",
        "hgnc": "HGNC:14415",
        "name": "ELOVL fatty acid elongase 4",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/elovl4"
      },
      {
        "slug": "prf1",
        "symbol": "PRF1",
        "hgnc": "HGNC:9360",
        "name": "perforin 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/prf1"
      },
      {
        "slug": "rbck1",
        "symbol": "RBCK1",
        "hgnc": "HGNC:15864",
        "name": "RANBP2-type and C3HC4-type zinc finger containing 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rbck1"
      },
      {
        "slug": "stx11",
        "symbol": "STX11",
        "hgnc": "HGNC:11429",
        "name": "syntaxin 11",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/stx11"
      },
      {
        "slug": "stxbp2",
        "symbol": "STXBP2",
        "hgnc": "HGNC:11445",
        "name": "syntaxin binding protein 2",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/stxbp2"
      },
      {
        "slug": "tom1",
        "symbol": "TOM1",
        "hgnc": "HGNC:11982",
        "name": "target of myb1 membrane trafficking protein",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tom1"
      },
      {
        "slug": "unc13d",
        "symbol": "UNC13D",
        "hgnc": "HGNC:23147",
        "name": "unc-13 homolog D",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/unc13d"
      },
      {
        "slug": "asprv1",
        "symbol": "ASPRV1",
        "hgnc": "HGNC:26321",
        "name": "aspartic peptidase retroviral like 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/asprv1"
      },
      {
        "slug": "cd3d",
        "symbol": "CD3D",
        "hgnc": "HGNC:1673",
        "name": "CD3 delta subunit of T-cell receptor complex",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cd3d"
      },
      {
        "slug": "cd3e",
        "symbol": "CD3E",
        "hgnc": "HGNC:1674",
        "name": "CD3 epsilon subunit of T-cell receptor complex",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cd3e"
      },
      {
        "slug": "cyp4f22",
        "symbol": "CYP4F22",
        "hgnc": "HGNC:26820",
        "name": "cytochrome P450 family 4 subfamily F member 22",
        "frequency": "occasional",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/cyp4f22"
      },
      {
        "slug": "dip2b",
        "symbol": "DIP2B",
        "hgnc": "HGNC:29284",
        "name": "DIP2 acetate--CoA ligase B (putative)",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dip2b"
      },
      {
        "slug": "extl3",
        "symbol": "EXTL3",
        "hgnc": "HGNC:3518",
        "name": "exostosin like glycosyltransferase 3",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/extl3"
      },
      {
        "slug": "foxp3",
        "symbol": "FOXP3",
        "hgnc": "HGNC:6106",
        "name": "forkhead box P3",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/foxp3"
      },
      {
        "slug": "lipn",
        "symbol": "LIPN",
        "hgnc": "HGNC:23452",
        "name": "lipase family member N",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lipn"
      },
      {
        "slug": "ercc2",
        "symbol": "ERCC2",
        "hgnc": "HGNC:3434",
        "name": "ERCC excision repair 2, TFIIH core complex helicase subunit",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ercc2"
      },
      {
        "slug": "lss",
        "symbol": "LSS",
        "hgnc": "HGNC:6708",
        "name": "lanosterol synthase",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lss"
      },
      {
        "slug": "mbtps2",
        "symbol": "MBTPS2",
        "hgnc": "HGNC:15455",
        "name": "membrane bound transcription factor peptidase, site 2",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mbtps2"
      },
      {
        "slug": "mpdu1",
        "symbol": "MPDU1",
        "hgnc": "HGNC:7207",
        "name": "mannose-P-dolichol utilization defect 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mpdu1"
      }
    ]
  }
}