{
  "url": "https://dantelabs.com/traits/dyspareunia",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "dyspareunia",
    "id": "HP:0030016",
    "name": "Dyspareunia",
    "definition": "Recurrent or persistent genital pain associated with sexual intercourse.",
    "synonyms": [],
    "systems": [
      {
        "slug": "abnormality-of-the-genitourinary-system",
        "name": "Abnormality of the genitourinary system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-genitourinary-system"
      }
    ],
    "broader": [
      {
        "slug": "abnormality-of-reproductive-system-physiology",
        "name": "Abnormality of reproductive system physiology",
        "url": "https://dantelabs.com/traits/abnormality-of-reproductive-system-physiology"
      }
    ],
    "narrower": [],
    "genes": [
      {
        "slug": "aip",
        "symbol": "AIP",
        "hgnc": "HGNC:358",
        "name": "AHR interacting HSP90 co-chaperone",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/aip"
      },
      {
        "slug": "cav1",
        "symbol": "CAV1",
        "hgnc": "HGNC:1527",
        "name": "caveolin 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cav1"
      },
      {
        "slug": "ccn2",
        "symbol": "CCN2",
        "hgnc": "HGNC:2500",
        "name": "cellular communication network factor 2",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ccn2"
      },
      {
        "slug": "ccr6",
        "symbol": "CCR6",
        "hgnc": "HGNC:1607",
        "name": "C-C motif chemokine receptor 6",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ccr6"
      },
      {
        "slug": "cdh23",
        "symbol": "CDH23",
        "hgnc": "HGNC:13733",
        "name": "cadherin related 23",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cdh23"
      },
      {
        "slug": "clec7a",
        "symbol": "CLEC7A",
        "hgnc": "HGNC:14558",
        "name": "C-type lectin domain containing 7A",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/clec7a"
      },
      {
        "slug": "fzd2",
        "symbol": "FZD2",
        "hgnc": "HGNC:4040",
        "name": "frizzled class receptor 2",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fzd2"
      },
      {
        "slug": "hla-drb1",
        "symbol": "HLA-DRB1",
        "hgnc": "HGNC:4948",
        "name": "major histocompatibility complex, class II, DR beta 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hla-drb1"
      },
      {
        "slug": "il17f",
        "symbol": "IL17F",
        "hgnc": "HGNC:16404",
        "name": "interleukin 17F",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/il17f"
      },
      {
        "slug": "il17ra",
        "symbol": "IL17RA",
        "hgnc": "HGNC:5985",
        "name": "interleukin 17 receptor A",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/il17ra"
      },
      {
        "slug": "il17rc",
        "symbol": "IL17RC",
        "hgnc": "HGNC:18358",
        "name": "interleukin 17 receptor C",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/il17rc"
      },
      {
        "slug": "irf5",
        "symbol": "IRF5",
        "hgnc": "HGNC:6120",
        "name": "interferon regulatory factor 5",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/irf5"
      },
      {
        "slug": "men1",
        "symbol": "MEN1",
        "hgnc": "HGNC:7010",
        "name": "menin 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/men1"
      },
      {
        "slug": "traf3ip2",
        "symbol": "TRAF3IP2",
        "hgnc": "HGNC:1343",
        "name": "TRAF3 interacting protein 2",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/traf3ip2"
      },
      {
        "slug": "anos1",
        "symbol": "ANOS1",
        "hgnc": "HGNC:6211",
        "name": "anosmin 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/anos1"
      },
      {
        "slug": "ccdc141",
        "symbol": "CCDC141",
        "hgnc": "HGNC:26821",
        "name": "coiled-coil domain containing 141",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ccdc141"
      },
      {
        "slug": "chd7",
        "symbol": "CHD7",
        "hgnc": "HGNC:20626",
        "name": "chromodomain helicase DNA binding protein 7",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/chd7"
      },
      {
        "slug": "dcc",
        "symbol": "DCC",
        "hgnc": "HGNC:2701",
        "name": "DCC netrin 1 receptor",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dcc"
      },
      {
        "slug": "dusp6",
        "symbol": "DUSP6",
        "hgnc": "HGNC:3072",
        "name": "dual specificity phosphatase 6",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dusp6"
      },
      {
        "slug": "emx2",
        "symbol": "EMX2",
        "hgnc": "HGNC:3341",
        "name": "empty spiracles homeobox 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/emx2"
      },
      {
        "slug": "fezf1",
        "symbol": "FEZF1",
        "hgnc": "HGNC:22788",
        "name": "FEZ family zinc finger 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fezf1"
      },
      {
        "slug": "fgf17",
        "symbol": "FGF17",
        "hgnc": "HGNC:3673",
        "name": "fibroblast growth factor 17",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fgf17"
      },
      {
        "slug": "fgf8",
        "symbol": "FGF8",
        "hgnc": "HGNC:3686",
        "name": "fibroblast growth factor 8",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fgf8"
      },
      {
        "slug": "fgfr1",
        "symbol": "FGFR1",
        "hgnc": "HGNC:3688",
        "name": "fibroblast growth factor receptor 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fgfr1"
      },
      {
        "slug": "flrt3",
        "symbol": "FLRT3",
        "hgnc": "HGNC:3762",
        "name": "fibronectin leucine rich transmembrane protein 3",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/flrt3"
      },
      {
        "slug": "hesx1",
        "symbol": "HESX1",
        "hgnc": "HGNC:4877",
        "name": "HESX homeobox 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hesx1"
      },
      {
        "slug": "hla-b",
        "symbol": "HLA-B",
        "hgnc": "HGNC:4932",
        "name": "major histocompatibility complex, class I, B",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hla-b"
      },
      {
        "slug": "hs6st1",
        "symbol": "HS6ST1",
        "hgnc": "HGNC:5201",
        "name": "heparan sulfate 6-O-sulfotransferase 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hs6st1"
      },
      {
        "slug": "ikzf1",
        "symbol": "IKZF1",
        "hgnc": "HGNC:13176",
        "name": "IKAROS family zinc finger 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ikzf1"
      },
      {
        "slug": "il17rd",
        "symbol": "IL17RD",
        "hgnc": "HGNC:17616",
        "name": "interleukin 17 receptor D",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/il17rd"
      },
      {
        "slug": "ndnf",
        "symbol": "NDNF",
        "hgnc": "HGNC:26256",
        "name": "neuron derived neurotrophic factor",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ndnf"
      },
      {
        "slug": "prok2",
        "symbol": "PROK2",
        "hgnc": "HGNC:18455",
        "name": "prokineticin 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/prok2"
      },
      {
        "slug": "prokr2",
        "symbol": "PROKR2",
        "hgnc": "HGNC:15836",
        "name": "prokineticin receptor 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/prokr2"
      },
      {
        "slug": "sema3a",
        "symbol": "SEMA3A",
        "hgnc": "HGNC:10723",
        "name": "semaphorin 3A",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sema3a"
      },
      {
        "slug": "sox10",
        "symbol": "SOX10",
        "hgnc": "HGNC:11190",
        "name": "SRY-box transcription factor 10",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sox10"
      },
      {
        "slug": "spry4",
        "symbol": "SPRY4",
        "hgnc": "HGNC:15533",
        "name": "sprouty RTK signaling antagonist 4",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/spry4"
      },
      {
        "slug": "tacr3",
        "symbol": "TACR3",
        "hgnc": "HGNC:11528",
        "name": "tachykinin receptor 3",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tacr3"
      },
      {
        "slug": "wdr11",
        "symbol": "WDR11",
        "hgnc": "HGNC:13831",
        "name": "WD repeat domain 11",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/wdr11"
      }
    ]
  }
}