{
  "url": "https://dantelabs.com/traits/decreased-circulating-terminal-complement-component-concentration",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "decreased-circulating-terminal-complement-component-concentration",
    "id": "HP:0033057",
    "name": "Decreased circulating terminal complement component concentration",
    "definition": "Concentration below the lower limit of normal of one or more components of the the terminal membrane attack complex (MAC) portion of complement, which represents the lytic, pore-forming part of the system. The MAC comprises seven components: C5b, C6, C7, C8 (a heterotrimer composed of C8alpha, C8beta and C8gamma) and multiple copies of C9.",
    "synonyms": [
      "Decreased serum terminal complement component"
    ],
    "systems": [
      {
        "slug": "abnormality-of-the-immune-system",
        "name": "Abnormality of the immune system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-immune-system"
      }
    ],
    "broader": [
      {
        "slug": "reduced-circulating-complement-concentration",
        "name": "Reduced circulating complement concentration",
        "url": "https://dantelabs.com/traits/reduced-circulating-complement-concentration"
      }
    ],
    "narrower": [
      {
        "slug": "decreased-circulating-complement-c8-concentration",
        "name": "Decreased circulating complement C8 concentration",
        "genes": 2,
        "url": "https://dantelabs.com/traits/decreased-circulating-complement-c8-concentration"
      },
      {
        "slug": "decreased-circulating-complement-c5-concentration",
        "name": "Decreased circulating complement C5 concentration",
        "genes": 1,
        "url": "https://dantelabs.com/traits/decreased-circulating-complement-c5-concentration"
      },
      {
        "slug": "decreased-circulating-complement-c6-concentration",
        "name": "Decreased circulating complement C6 concentration",
        "genes": 1,
        "url": "https://dantelabs.com/traits/decreased-circulating-complement-c6-concentration"
      },
      {
        "slug": "decreased-circulating-complement-c7-concentration",
        "name": "Decreased circulating complement C7 concentration",
        "genes": 1,
        "url": "https://dantelabs.com/traits/decreased-circulating-complement-c7-concentration"
      },
      {
        "slug": "decreased-circulating-complement-c9-concentration",
        "name": "Decreased circulating complement C9 concentration",
        "genes": 1,
        "url": "https://dantelabs.com/traits/decreased-circulating-complement-c9-concentration"
      }
    ],
    "genes": []
  }
}