{
  "url": "https://dantelabs.com/traits/conotruncal-defect",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "conotruncal-defect",
    "id": "HP:0001710",
    "name": "Conotruncal defect",
    "definition": "A congenital malformation of the outflow tract of the heart. Conotruncal defects are thought to result from a disturbance of the outflow tract of the embryonic heart, and comprise truncus arteriosus, tetralogy of Fallot, interrupted aortic arch, transposition of the great arteries, and double outlet right ventricle.",
    "synonyms": [
      "Conotruncal heart defects"
    ],
    "systems": [
      {
        "slug": "abnormality-of-the-cardiovascular-system",
        "name": "Abnormality of the cardiovascular system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-cardiovascular-system"
      }
    ],
    "broader": [
      {
        "slug": "abnormal-ventriculoarterial-connection",
        "name": "Abnormal ventriculoarterial connection",
        "url": "https://dantelabs.com/traits/abnormal-ventriculoarterial-connection"
      },
      {
        "slug": "congenital-malformation-of-the-great-arteries",
        "name": "Congenital malformation of the great arteries",
        "url": "https://dantelabs.com/traits/congenital-malformation-of-the-great-arteries"
      }
    ],
    "narrower": [
      {
        "slug": "tetralogy-of-fallot",
        "name": "Tetralogy of Fallot",
        "genes": 190,
        "url": "https://dantelabs.com/traits/tetralogy-of-fallot"
      },
      {
        "slug": "double-outlet-right-ventricle",
        "name": "Double outlet right ventricle",
        "genes": 96,
        "url": "https://dantelabs.com/traits/double-outlet-right-ventricle"
      }
    ],
    "genes": [
      {
        "slug": "ehmt1",
        "symbol": "EHMT1",
        "hgnc": "HGNC:24650",
        "name": "euchromatic histone lysine methyltransferase 1",
        "frequency": "occasional",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/ehmt1"
      },
      {
        "slug": "wt1",
        "symbol": "WT1",
        "hgnc": "HGNC:12796",
        "name": "WT1 transcription factor",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/wt1"
      }
    ]
  }
}