{
  "url": "https://dantelabs.com/traits/cirrhosis",
  "trait": {
    "bundleId": "2026.10.19-9814e911",
    "release": "2026-09-01",
    "slug": "cirrhosis",
    "id": "HP:0001394",
    "name": "Scar tissue replaces healthy tissue in the liver",
    "label": "Cirrhosis",
    "definition": "A chronic disorder of the liver in which liver tissue becomes scarred and is partially replaced by regenerative nodules and fibrotic tissue resulting in loss of liver function.",
    "synonyms": [
      "Hepatic cirrhosis"
    ],
    "systems": [
      {
        "slug": "abnormality-of-the-digestive-system",
        "name": "Abnormality of the digestive system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-digestive-system"
      }
    ],
    "broader": [
      {
        "slug": "abnormal-liver-morphology",
        "name": "Abnormal liver morphology",
        "url": "https://dantelabs.com/traits/abnormal-liver-morphology"
      }
    ],
    "narrower": [
      {
        "slug": "micronodular-cirrhosis",
        "name": "Micronodular cirrhosis",
        "genes": 23,
        "url": "https://dantelabs.com/traits/micronodular-cirrhosis"
      },
      {
        "slug": "macronodular-cirrhosis",
        "name": "Macronodular cirrhosis",
        "genes": 2,
        "url": "https://dantelabs.com/traits/macronodular-cirrhosis"
      }
    ],
    "genes": [
      {
        "slug": "abcb11",
        "symbol": "ABCB11",
        "hgnc": "HGNC:42",
        "name": "ATP binding cassette subfamily B member 11",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/abcb11"
      },
      {
        "slug": "abcb4",
        "symbol": "ABCB4",
        "hgnc": "HGNC:45",
        "name": "ATP binding cassette subfamily B member 4",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/abcb4"
      },
      {
        "slug": "arid2",
        "symbol": "ARID2",
        "hgnc": "HGNC:18037",
        "name": "AT-rich interaction domain 2",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/arid2"
      },
      {
        "slug": "atp7b",
        "symbol": "ATP7B",
        "hgnc": "HGNC:870",
        "name": "ATPase copper transporting beta",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/atp7b"
      },
      {
        "slug": "atp8b1",
        "symbol": "ATP8B1",
        "hgnc": "HGNC:3706",
        "name": "ATPase phospholipid transporting 8B1",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/atp8b1"
      },
      {
        "slug": "cyp7b1",
        "symbol": "CYP7B1",
        "hgnc": "HGNC:2652",
        "name": "cytochrome P450 family 7 subfamily B member 1",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/cyp7b1"
      },
      {
        "slug": "dhcr7",
        "symbol": "DHCR7",
        "hgnc": "HGNC:2860",
        "name": "7-dehydrocholesterol reductase",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dhcr7"
      },
      {
        "slug": "hamp",
        "symbol": "HAMP",
        "hgnc": "HGNC:15598",
        "name": "hepcidin antimicrobial peptide",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hamp"
      },
      {
        "slug": "mpi",
        "symbol": "MPI",
        "hgnc": "HGNC:7216",
        "name": "mannose phosphate isomerase",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mpi"
      },
      {
        "slug": "nphp3",
        "symbol": "NPHP3",
        "hgnc": "HGNC:7907",
        "name": "nephrocystin 3",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/nphp3"
      },
      {
        "slug": "nr1h4",
        "symbol": "NR1H4",
        "hgnc": "HGNC:7967",
        "name": "nuclear receptor subfamily 1 group H member 4",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nr1h4"
      },
      {
        "slug": "phkg2",
        "symbol": "PHKG2",
        "hgnc": "HGNC:8931",
        "name": "phosphorylase kinase catalytic subunit gamma 2",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/phkg2"
      },
      {
        "slug": "pskh1",
        "symbol": "PSKH1",
        "hgnc": "HGNC:9529",
        "name": "protein serine kinase H1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pskh1"
      },
      {
        "slug": "serpina1",
        "symbol": "SERPINA1",
        "hgnc": "HGNC:8941",
        "name": "serpin family A member 1",
        "frequency": "obligate",
        "diseases": 3,
        "url": "https://dantelabs.com/genes/serpina1"
      },
      {
        "slug": "tjp2",
        "symbol": "TJP2",
        "hgnc": "HGNC:11828",
        "name": "tight junction protein 2",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tjp2"
      },
      {
        "slug": "trmt5",
        "symbol": "TRMT5",
        "hgnc": "HGNC:23141",
        "name": "tRNA methyltransferase 5",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/trmt5"
      },
      {
        "slug": "bcs1l",
        "symbol": "BCS1L",
        "hgnc": "HGNC:1020",
        "name": "BCS1 ubiquinol-cytochrome c reductase complex chaperone",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/bcs1l"
      },
      {
        "slug": "il12a",
        "symbol": "IL12A",
        "hgnc": "HGNC:5969",
        "name": "interleukin 12A",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/il12a"
      },
      {
        "slug": "il12rb1",
        "symbol": "IL12RB1",
        "hgnc": "HGNC:5971",
        "name": "interleukin 12 receptor subunit beta 1",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/il12rb1"
      },
      {
        "slug": "irf5",
        "symbol": "IRF5",
        "hgnc": "HGNC:6120",
        "name": "interferon regulatory factor 5",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/irf5"
      },
      {
        "slug": "mmel1",
        "symbol": "MMEL1",
        "hgnc": "HGNC:14668",
        "name": "membrane metalloendopeptidase like 1",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mmel1"
      },
      {
        "slug": "pou2af1",
        "symbol": "POU2AF1",
        "hgnc": "HGNC:9211",
        "name": "POU class 2 homeobox associating factor 1",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pou2af1"
      },
      {
        "slug": "slc30a10",
        "symbol": "SLC30A10",
        "hgnc": "HGNC:25355",
        "name": "solute carrier family 30 member 10",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slc30a10"
      },
      {
        "slug": "spib",
        "symbol": "SPIB",
        "hgnc": "HGNC:11242",
        "name": "Spi-B transcription factor",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/spib"
      },
      {
        "slug": "taldo1",
        "symbol": "TALDO1",
        "hgnc": "HGNC:11559",
        "name": "transaldolase 1",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/taldo1"
      },
      {
        "slug": "tnfsf15",
        "symbol": "TNFSF15",
        "hgnc": "HGNC:11931",
        "name": "TNF superfamily member 15",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tnfsf15"
      },
      {
        "slug": "tnpo3",
        "symbol": "TNPO3",
        "hgnc": "HGNC:17103",
        "name": "transportin 3",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tnpo3"
      },
      {
        "slug": "ap1s1",
        "symbol": "AP1S1",
        "hgnc": "HGNC:559",
        "name": "adaptor related protein complex 1 subunit sigma 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ap1s1"
      },
      {
        "slug": "atp6ap1",
        "symbol": "ATP6AP1",
        "hgnc": "HGNC:868",
        "name": "ATPase H+ transporting accessory protein 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/atp6ap1"
      },
      {
        "slug": "calr",
        "symbol": "CALR",
        "hgnc": "HGNC:1455",
        "name": "calreticulin",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/calr"
      },
      {
        "slug": "cog4",
        "symbol": "COG4",
        "hgnc": "HGNC:18620",
        "name": "component of oligomeric golgi complex 4",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/cog4"
      },
      {
        "slug": "dcdc2",
        "symbol": "DCDC2",
        "hgnc": "HGNC:18141",
        "name": "doublecortin domain containing 2",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/dcdc2"
      },
      {
        "slug": "f5",
        "symbol": "F5",
        "hgnc": "HGNC:3542",
        "name": "coagulation factor V",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/f5"
      },
      {
        "slug": "farsb",
        "symbol": "FARSB",
        "hgnc": "HGNC:17800",
        "name": "phenylalanyl-tRNA synthetase subunit beta",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/farsb"
      },
      {
        "slug": "gpr35",
        "symbol": "GPR35",
        "hgnc": "HGNC:4492",
        "name": "G protein-coupled receptor 35",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gpr35"
      },
      {
        "slug": "hjv",
        "symbol": "HJV",
        "hgnc": "HGNC:4887",
        "name": "hemojuvelin BMP co-receptor",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hjv"
      },
      {
        "slug": "ift43",
        "symbol": "IFT43",
        "hgnc": "HGNC:29669",
        "name": "intraflagellar transport 43",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ift43"
      },
      {
        "slug": "jak2",
        "symbol": "JAK2",
        "hgnc": "HGNC:6192",
        "name": "Janus kinase 2",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/jak2"
      },
      {
        "slug": "kif12",
        "symbol": "KIF12",
        "hgnc": "HGNC:21495",
        "name": "kinesin family member 12",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/kif12"
      },
      {
        "slug": "krt18",
        "symbol": "KRT18",
        "hgnc": "HGNC:6430",
        "name": "keratin 18",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/krt18"
      },
      {
        "slug": "lipa",
        "symbol": "LIPA",
        "hgnc": "HGNC:6617",
        "name": "lipase A, lysosomal acid type",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/lipa"
      },
      {
        "slug": "mpv17",
        "symbol": "MPV17",
        "hgnc": "HGNC:7224",
        "name": "mitochondrial inner membrane protein MPV17",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mpv17"
      },
      {
        "slug": "mst1",
        "symbol": "MST1",
        "hgnc": "HGNC:7380",
        "name": "macrophage stimulating 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mst1"
      },
      {
        "slug": "nhp2",
        "symbol": "NHP2",
        "hgnc": "HGNC:14377",
        "name": "NHP2 ribonucleoprotein",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/nhp2"
      },
      {
        "slug": "psmb9",
        "symbol": "PSMB9",
        "hgnc": "HGNC:9546",
        "name": "proteasome 20S subunit beta 9",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/psmb9"
      },
      {
        "slug": "sema4d",
        "symbol": "SEMA4D",
        "hgnc": "HGNC:10732",
        "name": "semaphorin 4D",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sema4d"
      },
      {
        "slug": "skic2",
        "symbol": "SKIC2",
        "hgnc": "HGNC:10898",
        "name": "SKI2 subunit of superkiller complex",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/skic2"
      },
      {
        "slug": "skic3",
        "symbol": "SKIC3",
        "hgnc": "HGNC:23639",
        "name": "SKI3 subunit of superkiller complex",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/skic3"
      },
      {
        "slug": "slc7a7",
        "symbol": "SLC7A7",
        "hgnc": "HGNC:11065",
        "name": "solute carrier family 7 member 7",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slc7a7"
      },
      {
        "slug": "tcf4",
        "symbol": "TCF4",
        "hgnc": "HGNC:11634",
        "name": "transcription factor 4",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tcf4"
      },
      {
        "slug": "tfam",
        "symbol": "TFAM",
        "hgnc": "HGNC:11741",
        "name": "transcription factor A, mitochondrial",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tfam"
      },
      {
        "slug": "tulp3",
        "symbol": "TULP3",
        "hgnc": "HGNC:12425",
        "name": "TUB like protein 3",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tulp3"
      },
      {
        "slug": "yars1",
        "symbol": "YARS1",
        "hgnc": "HGNC:12840",
        "name": "tyrosyl-tRNA synthetase 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/yars1"
      },
      {
        "slug": "acd",
        "symbol": "ACD",
        "hgnc": "HGNC:25070",
        "name": "ACD shelterin complex subunit and telomerase recruitment factor",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/acd"
      },
      {
        "slug": "acvrl1",
        "symbol": "ACVRL1",
        "hgnc": "HGNC:175",
        "name": "activin A receptor like type 1",
        "frequency": "occasional",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/acvrl1"
      },
      {
        "slug": "alms1",
        "symbol": "ALMS1",
        "hgnc": "HGNC:428",
        "name": "ALMS1 centrosome and basal body associated protein",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/alms1"
      },
      {
        "slug": "arhgap31",
        "symbol": "ARHGAP31",
        "hgnc": "HGNC:29216",
        "name": "Rho GTPase activating protein 31",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/arhgap31"
      },
      {
        "slug": "asl",
        "symbol": "ASL",
        "hgnc": "HGNC:746",
        "name": "argininosuccinate lyase",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/asl"
      },
      {
        "slug": "bmp6",
        "symbol": "BMP6",
        "hgnc": "HGNC:1073",
        "name": "bone morphogenetic protein 6",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/bmp6"
      },
      {
        "slug": "bscl2",
        "symbol": "BSCL2",
        "hgnc": "HGNC:15832",
        "name": "BSCL2 lipid droplet biogenesis associated, seipin",
        "frequency": "occasional",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/bscl2"
      },
      {
        "slug": "cc2d2a",
        "symbol": "CC2D2A",
        "hgnc": "HGNC:29253",
        "name": "coiled-coil and C2 domain containing 2A",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cc2d2a"
      },
      {
        "slug": "cd40lg",
        "symbol": "CD40LG",
        "hgnc": "HGNC:11935",
        "name": "CD40 ligand",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cd40lg"
      },
      {
        "slug": "cog6",
        "symbol": "COG6",
        "hgnc": "HGNC:18621",
        "name": "component of oligomeric golgi complex 6",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cog6"
      },
      {
        "slug": "ctc1",
        "symbol": "CTC1",
        "hgnc": "HGNC:26169",
        "name": "CST telomere replication complex component 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ctc1"
      },
      {
        "slug": "dkc1",
        "symbol": "DKC1",
        "hgnc": "HGNC:2890",
        "name": "dyskerin pseudouridine synthase 1",
        "frequency": "occasional",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/dkc1"
      },
      {
        "slug": "dll4",
        "symbol": "DLL4",
        "hgnc": "HGNC:2910",
        "name": "delta like canonical Notch ligand 4",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dll4"
      },
      {
        "slug": "dock6",
        "symbol": "DOCK6",
        "hgnc": "HGNC:19189",
        "name": "dedicator of cytokinesis 6",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dock6"
      },
      {
        "slug": "eng",
        "symbol": "ENG",
        "hgnc": "HGNC:3349",
        "name": "endoglin",
        "frequency": "occasional",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/eng"
      },
      {
        "slug": "eogt",
        "symbol": "EOGT",
        "hgnc": "HGNC:28526",
        "name": "EGF domain specific O-linked N-acetylglucosamine transferase",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/eogt"
      },
      {
        "slug": "fech",
        "symbol": "FECH",
        "hgnc": "HGNC:3647",
        "name": "ferrochelatase",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fech"
      },
      {
        "slug": "gdf2",
        "symbol": "GDF2",
        "hgnc": "HGNC:4217",
        "name": "growth differentiation factor 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gdf2"
      },
      {
        "slug": "glrx5",
        "symbol": "GLRX5",
        "hgnc": "HGNC:20134",
        "name": "glutaredoxin 5",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/glrx5"
      },
      {
        "slug": "hbb",
        "symbol": "HBB",
        "hgnc": "HGNC:4827",
        "name": "hemoglobin subunit beta",
        "frequency": "occasional",
        "diseases": 3,
        "url": "https://dantelabs.com/genes/hbb"
      },
      {
        "slug": "hfe",
        "symbol": "HFE",
        "hgnc": "HGNC:4886",
        "name": "homeostatic iron regulator",
        "frequency": "occasional",
        "diseases": 3,
        "url": "https://dantelabs.com/genes/hfe"
      },
      {
        "slug": "hsd3b7",
        "symbol": "HSD3B7",
        "hgnc": "HGNC:18324",
        "name": "hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7",
        "frequency": "occasional",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/hsd3b7"
      },
      {
        "slug": "ift56",
        "symbol": "IFT56",
        "hgnc": "HGNC:21882",
        "name": "intraflagellar transport 56",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ift56"
      },
      {
        "slug": "il21r",
        "symbol": "IL21R",
        "hgnc": "HGNC:6006",
        "name": "interleukin 21 receptor",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/il21r"
      },
      {
        "slug": "inpp5e",
        "symbol": "INPP5E",
        "hgnc": "HGNC:21474",
        "name": "inositol polyphosphate-5-phosphatase E",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/inpp5e"
      },
      {
        "slug": "itch",
        "symbol": "ITCH",
        "hgnc": "HGNC:13890",
        "name": "itchy E3 ubiquitin protein ligase",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/itch"
      },
      {
        "slug": "lbr",
        "symbol": "LBR",
        "hgnc": "HGNC:6518",
        "name": "lamin B receptor",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lbr"
      },
      {
        "slug": "lig3",
        "symbol": "LIG3",
        "hgnc": "HGNC:6600",
        "name": "DNA ligase 3",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lig3"
      },
      {
        "slug": "mars1",
        "symbol": "MARS1",
        "hgnc": "HGNC:6898",
        "name": "methionyl-tRNA synthetase 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mars1"
      },
      {
        "slug": "med12",
        "symbol": "MED12",
        "hgnc": "HGNC:11957",
        "name": "mediator complex subunit 12",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/med12"
      },
      {
        "slug": "nek8",
        "symbol": "NEK8",
        "hgnc": "HGNC:13387",
        "name": "NIMA related kinase 8",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nek8"
      },
      {
        "slug": "nop10",
        "symbol": "NOP10",
        "hgnc": "HGNC:14378",
        "name": "NOP10 ribonucleoprotein",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nop10"
      },
      {
        "slug": "notch1",
        "symbol": "NOTCH1",
        "hgnc": "HGNC:7881",
        "name": "notch receptor 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/notch1"
      },
      {
        "slug": "npm1",
        "symbol": "NPM1",
        "hgnc": "HGNC:7910",
        "name": "nucleophosmin 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/npm1"
      },
      {
        "slug": "parn",
        "symbol": "PARN",
        "hgnc": "HGNC:8609",
        "name": "poly(A)-specific ribonuclease",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/parn"
      },
      {
        "slug": "phkb",
        "symbol": "PHKB",
        "hgnc": "HGNC:8927",
        "name": "phosphorylase kinase regulatory subunit beta",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/phkb"
      },
      {
        "slug": "piga",
        "symbol": "PIGA",
        "hgnc": "HGNC:8957",
        "name": "phosphatidylinositol glycan anchor biosynthesis class A",
        "frequency": "occasional",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/piga"
      },
      {
        "slug": "pkhd1",
        "symbol": "PKHD1",
        "hgnc": "HGNC:9016",
        "name": "PKHD1 ciliary IPT domain containing fibrocystin/polyductin",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pkhd1"
      },
      {
        "slug": "polg",
        "symbol": "POLG",
        "hgnc": "HGNC:9179",
        "name": "DNA polymerase gamma, catalytic subunit",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/polg"
      },
      {
        "slug": "rbpj",
        "symbol": "RBPJ",
        "hgnc": "HGNC:5724",
        "name": "recombination signal binding protein for immunoglobulin kappa J region",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rbpj"
      },
      {
        "slug": "rpgrip1l",
        "symbol": "RPGRIP1L",
        "hgnc": "HGNC:29168",
        "name": "RPGRIP1 like",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rpgrip1l"
      },
      {
        "slug": "rrm2b",
        "symbol": "RRM2B",
        "hgnc": "HGNC:17296",
        "name": "ribonucleotide reductase regulatory TP53 inducible subunit M2B",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rrm2b"
      },
      {
        "slug": "rtel1",
        "symbol": "RTEL1",
        "hgnc": "HGNC:15888",
        "name": "regulator of telomere elongation helicase 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rtel1"
      },
      {
        "slug": "slc40a1",
        "symbol": "SLC40A1",
        "hgnc": "HGNC:10909",
        "name": "solute carrier family 40 member 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slc40a1"
      },
      {
        "slug": "smad4",
        "symbol": "SMAD4",
        "hgnc": "HGNC:6770",
        "name": "SMAD family member 4",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/smad4"
      },
      {
        "slug": "terc",
        "symbol": "TERC",
        "hgnc": "HGNC:11727",
        "name": "telomerase RNA component",
        "frequency": "occasional",
        "diseases": 4,
        "url": "https://dantelabs.com/genes/terc"
      },
      {
        "slug": "tert",
        "symbol": "TERT",
        "hgnc": "HGNC:11730",
        "name": "telomerase reverse transcriptase",
        "frequency": "occasional",
        "diseases": 4,
        "url": "https://dantelabs.com/genes/tert"
      },
      {
        "slug": "tfr2",
        "symbol": "TFR2",
        "hgnc": "HGNC:11762",
        "name": "transferrin receptor 2",
        "frequency": "occasional",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/tfr2"
      },
      {
        "slug": "tinf2",
        "symbol": "TINF2",
        "hgnc": "HGNC:11824",
        "name": "TERF1 interacting nuclear factor 2",
        "frequency": "occasional",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/tinf2"
      },
      {
        "slug": "tmem67",
        "symbol": "TMEM67",
        "hgnc": "HGNC:28396",
        "name": "transmembrane protein 67",
        "frequency": "occasional",
        "diseases": 3,
        "url": "https://dantelabs.com/genes/tmem67"
      },
      {
        "slug": "tuba4a",
        "symbol": "TUBA4A",
        "hgnc": "HGNC:12407",
        "name": "tubulin alpha 4a",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tuba4a"
      },
      {
        "slug": "tymp",
        "symbol": "TYMP",
        "hgnc": "HGNC:3148",
        "name": "thymidine phosphorylase",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tymp"
      },
      {
        "slug": "tyms",
        "symbol": "TYMS",
        "hgnc": "HGNC:12441",
        "name": "thymidylate synthetase",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tyms"
      },
      {
        "slug": "usb1",
        "symbol": "USB1",
        "hgnc": "HGNC:25792",
        "name": "U6 snRNA biogenesis phosphodiesterase 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/usb1"
      },
      {
        "slug": "wrap53",
        "symbol": "WRAP53",
        "hgnc": "HGNC:25522",
        "name": "WD repeat containing antisense to TP53",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/wrap53"
      },
      {
        "slug": "acbd6",
        "symbol": "ACBD6",
        "hgnc": "HGNC:23339",
        "name": "acyl-CoA binding domain containing 6",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/acbd6"
      },
      {
        "slug": "ceacam3",
        "symbol": "CEACAM3",
        "hgnc": "HGNC:1815",
        "name": "CEA cell adhesion molecule 3",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ceacam3"
      },
      {
        "slug": "ceacam6",
        "symbol": "CEACAM6",
        "hgnc": "HGNC:1818",
        "name": "CEA cell adhesion molecule 6",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ceacam6"
      },
      {
        "slug": "cftr",
        "symbol": "CFTR",
        "hgnc": "HGNC:1884",
        "name": "CF transmembrane conductance regulator",
        "frequency": "very-rare",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/cftr"
      },
      {
        "slug": "clca4",
        "symbol": "CLCA4",
        "hgnc": "HGNC:2018",
        "name": "chloride channel accessory 4",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/clca4"
      },
      {
        "slug": "dctn4",
        "symbol": "DCTN4",
        "hgnc": "HGNC:15518",
        "name": "dynactin subunit 4",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dctn4"
      },
      {
        "slug": "ednra",
        "symbol": "EDNRA",
        "hgnc": "HGNC:3179",
        "name": "endothelin receptor type A",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ednra"
      },
      {
        "slug": "fcgr2a",
        "symbol": "FCGR2A",
        "hgnc": "HGNC:3616",
        "name": "Fc gamma receptor IIa",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fcgr2a"
      },
      {
        "slug": "gba1",
        "symbol": "GBA1",
        "hgnc": "HGNC:4177",
        "name": "glucosylceramidase beta 1",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gba1"
      },
      {
        "slug": "gclc",
        "symbol": "GCLC",
        "hgnc": "HGNC:4311",
        "name": "glutamate-cysteine ligase catalytic subunit",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gclc"
      },
      {
        "slug": "gstm3",
        "symbol": "GSTM3",
        "hgnc": "HGNC:4635",
        "name": "glutathione S-transferase mu 3",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gstm3"
      },
      {
        "slug": "hmox1",
        "symbol": "HMOX1",
        "hgnc": "HGNC:5013",
        "name": "heme oxygenase 1",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hmox1"
      },
      {
        "slug": "kcnn4",
        "symbol": "KCNN4",
        "hgnc": "HGNC:6293",
        "name": "potassium calcium-activated channel subfamily N member 4",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/kcnn4"
      },
      {
        "slug": "mif",
        "symbol": "MIF",
        "hgnc": "HGNC:7097",
        "name": "macrophage migration inhibitory factor",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mif"
      },
      {
        "slug": "mttp",
        "symbol": "MTTP",
        "hgnc": "HGNC:7467",
        "name": "microsomal triglyceride transfer protein",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mttp"
      },
      {
        "slug": "phka2",
        "symbol": "PHKA2",
        "hgnc": "HGNC:8926",
        "name": "phosphorylase kinase regulatory subunit alpha 2",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/phka2"
      },
      {
        "slug": "pparg",
        "symbol": "PPARG",
        "hgnc": "HGNC:9236",
        "name": "peroxisome proliferator activated receptor gamma",
        "frequency": "very-rare",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/pparg"
      },
      {
        "slug": "pygl",
        "symbol": "PYGL",
        "hgnc": "HGNC:9725",
        "name": "glycogen phosphorylase L",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pygl"
      },
      {
        "slug": "scarb2",
        "symbol": "SCARB2",
        "hgnc": "HGNC:1665",
        "name": "scavenger receptor class B member 2",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/scarb2"
      },
      {
        "slug": "slc11a1",
        "symbol": "SLC11A1",
        "hgnc": "HGNC:10907",
        "name": "solute carrier family 11 member 1",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slc11a1"
      },
      {
        "slug": "slc26a9",
        "symbol": "SLC26A9",
        "hgnc": "HGNC:14469",
        "name": "solute carrier family 26 member 9",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slc26a9"
      },
      {
        "slug": "slc6a14",
        "symbol": "SLC6A14",
        "hgnc": "HGNC:11047",
        "name": "solute carrier family 6 member 14",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slc6a14"
      },
      {
        "slug": "slc9a3",
        "symbol": "SLC9A3",
        "hgnc": "HGNC:11073",
        "name": "solute carrier family 9 member A3",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slc9a3"
      },
      {
        "slug": "smpd1",
        "symbol": "SMPD1",
        "hgnc": "HGNC:11120",
        "name": "sphingomyelin phosphodiesterase 1",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/smpd1"
      },
      {
        "slug": "stx1a",
        "symbol": "STX1A",
        "hgnc": "HGNC:11433",
        "name": "syntaxin 1A",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/stx1a"
      },
      {
        "slug": "tgfb1",
        "symbol": "TGFB1",
        "hgnc": "HGNC:11766",
        "name": "transforming growth factor beta 1",
        "frequency": "very-rare",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/tgfb1"
      },
      {
        "slug": "agpat2",
        "symbol": "AGPAT2",
        "hgnc": "HGNC:325",
        "name": "1-acylglycerol-3-phosphate O-acyltransferase 2",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/agpat2"
      },
      {
        "slug": "aldob",
        "symbol": "ALDOB",
        "hgnc": "HGNC:417",
        "name": "aldolase, fructose-bisphosphate B",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/aldob"
      },
      {
        "slug": "ap1b1",
        "symbol": "AP1B1",
        "hgnc": "HGNC:554",
        "name": "adaptor related protein complex 1 subunit beta 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ap1b1"
      },
      {
        "slug": "apoe",
        "symbol": "APOE",
        "hgnc": "HGNC:613",
        "name": "apolipoprotein E",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/apoe"
      },
      {
        "slug": "ass1",
        "symbol": "ASS1",
        "hgnc": "HGNC:758",
        "name": "argininosuccinate synthase 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ass1"
      },
      {
        "slug": "bmp2",
        "symbol": "BMP2",
        "hgnc": "HGNC:1069",
        "name": "bone morphogenetic protein 2",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/bmp2"
      },
      {
        "slug": "cp",
        "symbol": "CP",
        "hgnc": "HGNC:2295",
        "name": "ceruloplasmin",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cp"
      },
      {
        "slug": "fah",
        "symbol": "FAH",
        "hgnc": "HGNC:3579",
        "name": "fumarylacetoacetate hydrolase",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fah"
      },
      {
        "slug": "galt",
        "symbol": "GALT",
        "hgnc": "HGNC:4135",
        "name": "galactose-1-phosphate uridylyltransferase",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/galt"
      },
      {
        "slug": "gbe1",
        "symbol": "GBE1",
        "hgnc": "HGNC:4180",
        "name": "1,4-alpha-glucan branching enzyme 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gbe1"
      },
      {
        "slug": "jag1",
        "symbol": "JAG1",
        "hgnc": "HGNC:6188",
        "name": "jagged canonical Notch ligand 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/jag1"
      },
      {
        "slug": "muc5b",
        "symbol": "MUC5B",
        "hgnc": "HGNC:7516",
        "name": "mucin 5B, oligomeric mucus/gel-forming",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/muc5b"
      },
      {
        "slug": "pex1",
        "symbol": "PEX1",
        "hgnc": "HGNC:8850",
        "name": "peroxisomal biogenesis factor 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pex1"
      },
      {
        "slug": "sftpa2",
        "symbol": "SFTPA2",
        "hgnc": "HGNC:10799",
        "name": "surfactant protein A2",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sftpa2"
      },
      {
        "slug": "sftpc",
        "symbol": "SFTPC",
        "hgnc": "HGNC:10802",
        "name": "surfactant protein C",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sftpc"
      },
      {
        "slug": "slc25a13",
        "symbol": "SLC25A13",
        "hgnc": "HGNC:10983",
        "name": "solute carrier family 25 member 13",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slc25a13"
      },
      {
        "slug": "urod",
        "symbol": "UROD",
        "hgnc": "HGNC:12591",
        "name": "uroporphyrinogen decarboxylase",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/urod"
      },
      {
        "slug": "vma22",
        "symbol": "VMA22",
        "hgnc": "HGNC:28178",
        "name": "vacuolar ATPase assembly factor VMA22",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/vma22"
      }
    ]
  }
}