{
  "url": "https://dantelabs.com/traits/cardiac-diverticulum",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "cardiac-diverticulum",
    "id": "HP:0100571",
    "name": "Cardiac diverticulum",
    "definition": "A cardiac diverticulum is a rare congenital malformation which is either fibrous or muscular.",
    "synonyms": [
      "Ventricular diverticulum"
    ],
    "systems": [
      {
        "slug": "abnormality-of-the-cardiovascular-system",
        "name": "Abnormality of the cardiovascular system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-cardiovascular-system"
      }
    ],
    "broader": [
      {
        "slug": "abnormal-cardiac-ventricle-morphology",
        "name": "Abnormal cardiac ventricle morphology",
        "url": "https://dantelabs.com/traits/abnormal-cardiac-ventricle-morphology"
      }
    ],
    "narrower": [],
    "genes": [
      {
        "slug": "atm",
        "symbol": "ATM",
        "hgnc": "HGNC:795",
        "name": "ATM serine/threonine kinase",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/atm"
      },
      {
        "slug": "bmpr1a",
        "symbol": "BMPR1A",
        "hgnc": "HGNC:1076",
        "name": "bone morphogenetic protein receptor type 1A",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/bmpr1a"
      },
      {
        "slug": "brca2",
        "symbol": "BRCA2",
        "hgnc": "HGNC:1101",
        "name": "BRCA2 DNA repair associated",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/brca2"
      },
      {
        "slug": "chek2",
        "symbol": "CHEK2",
        "hgnc": "HGNC:16627",
        "name": "checkpoint kinase 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/chek2"
      },
      {
        "slug": "epcam",
        "symbol": "EPCAM",
        "hgnc": "HGNC:11529",
        "name": "epithelial cell adhesion molecule",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/epcam"
      },
      {
        "slug": "kras",
        "symbol": "KRAS",
        "hgnc": "HGNC:6407",
        "name": "KRas proto-oncogene, GTPase",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/kras"
      },
      {
        "slug": "mlh1",
        "symbol": "MLH1",
        "hgnc": "HGNC:7127",
        "name": "mutL homolog 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mlh1"
      },
      {
        "slug": "msh2",
        "symbol": "MSH2",
        "hgnc": "HGNC:7325",
        "name": "mutS homolog 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/msh2"
      },
      {
        "slug": "msh6",
        "symbol": "MSH6",
        "hgnc": "HGNC:7329",
        "name": "mutS homolog 6",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/msh6"
      },
      {
        "slug": "mutyh",
        "symbol": "MUTYH",
        "hgnc": "HGNC:7527",
        "name": "mutY DNA glycosylase",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mutyh"
      },
      {
        "slug": "npat",
        "symbol": "NPAT",
        "hgnc": "HGNC:7896",
        "name": "nuclear protein, coactivator of histone transcription",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/npat"
      },
      {
        "slug": "pik3ca",
        "symbol": "PIK3CA",
        "hgnc": "HGNC:8975",
        "name": "phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pik3ca"
      },
      {
        "slug": "pms1",
        "symbol": "PMS1",
        "hgnc": "HGNC:9121",
        "name": "PMS1 homolog 1, mismatch repair system component",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pms1"
      },
      {
        "slug": "pms2",
        "symbol": "PMS2",
        "hgnc": "HGNC:9122",
        "name": "PMS1 homolog 2, mismatch repair system component",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pms2"
      },
      {
        "slug": "pold1",
        "symbol": "POLD1",
        "hgnc": "HGNC:9175",
        "name": "DNA polymerase delta 1, catalytic subunit",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pold1"
      },
      {
        "slug": "pole",
        "symbol": "POLE",
        "hgnc": "HGNC:9177",
        "name": "DNA polymerase epsilon, catalytic subunit",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pole"
      },
      {
        "slug": "rps20",
        "symbol": "RPS20",
        "hgnc": "HGNC:10405",
        "name": "ribosomal protein S20",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rps20"
      },
      {
        "slug": "sema4a",
        "symbol": "SEMA4A",
        "hgnc": "HGNC:10729",
        "name": "semaphorin 4A",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sema4a"
      },
      {
        "slug": "tgfbr2",
        "symbol": "TGFBR2",
        "hgnc": "HGNC:11773",
        "name": "transforming growth factor beta receptor 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tgfbr2"
      }
    ]
  }
}