{
  "url": "https://dantelabs.com/traits/atherosclerosis",
  "trait": {
    "bundleId": "2026.10.18-8b139e39",
    "release": "2026-09-01",
    "slug": "atherosclerosis",
    "id": "HP:0002621",
    "name": "Narrowing and hardening of arteries",
    "label": "Atherosclerosis",
    "definition": "A condition characterized by patchy atheromas or atherosclerotic plaques which develop in the walls of medium-sized and large arteries and can lead to arterial stenosis with reduced or blocked blood flow.",
    "synonyms": [
      "Plaque build-up in arteries",
      "Atherosclerotic cardiovascular disease"
    ],
    "systems": [
      {
        "slug": "abnormality-of-the-cardiovascular-system",
        "name": "Abnormality of the cardiovascular system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-cardiovascular-system"
      }
    ],
    "broader": [
      {
        "slug": "arteriosclerosis",
        "name": "Hardened artery wall",
        "url": "https://dantelabs.com/traits/arteriosclerosis"
      }
    ],
    "narrower": [
      {
        "slug": "coronary-artery-atherosclerosis",
        "name": "Plaque build-up in arteries supplying blood to heart",
        "genes": 47,
        "url": "https://dantelabs.com/traits/coronary-artery-atherosclerosis"
      },
      {
        "slug": "foam-cells",
        "name": "Foam cells",
        "genes": 11,
        "url": "https://dantelabs.com/traits/foam-cells"
      },
      {
        "slug": "precocious-atherosclerosis",
        "name": "Premature plaque build-up in arteries",
        "genes": 10,
        "url": "https://dantelabs.com/traits/precocious-atherosclerosis"
      },
      {
        "slug": "aortic-atherosclerotic-lesion",
        "name": "Aortic atherosclerotic lesion",
        "genes": 9,
        "url": "https://dantelabs.com/traits/aortic-atherosclerotic-lesion"
      },
      {
        "slug": "accelerated-atherosclerosis",
        "name": "Accelerated plaque build-up in arteries",
        "genes": 8,
        "url": "https://dantelabs.com/traits/accelerated-atherosclerosis"
      },
      {
        "slug": "cerebral-artery-atherosclerosis",
        "name": "Plaque build-up in cerebral artery",
        "genes": 6,
        "url": "https://dantelabs.com/traits/cerebral-artery-atherosclerosis"
      },
      {
        "slug": "atherosclerotic-lesion",
        "name": "Atherosclerotic lesion",
        "genes": 0,
        "url": "https://dantelabs.com/traits/atherosclerotic-lesion"
      }
    ],
    "genes": [
      {
        "slug": "abca1",
        "symbol": "ABCA1",
        "hgnc": "HGNC:29",
        "name": "ATP binding cassette subfamily A member 1",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/abca1"
      },
      {
        "slug": "apoa1",
        "symbol": "APOA1",
        "hgnc": "HGNC:600",
        "name": "apolipoprotein A1",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/apoa1"
      },
      {
        "slug": "angptl6",
        "symbol": "ANGPTL6",
        "hgnc": "HGNC:23140",
        "name": "angiopoietin like 6",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/angptl6"
      },
      {
        "slug": "col3a1",
        "symbol": "COL3A1",
        "hgnc": "HGNC:2201",
        "name": "collagen type III alpha 1 chain",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/col3a1"
      },
      {
        "slug": "eng",
        "symbol": "ENG",
        "hgnc": "HGNC:3349",
        "name": "endoglin",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/eng"
      },
      {
        "slug": "ggcx",
        "symbol": "GGCX",
        "hgnc": "HGNC:4247",
        "name": "gamma-glutamyl carboxylase",
        "frequency": "frequent",
        "diseases": 3,
        "url": "https://dantelabs.com/genes/ggcx"
      },
      {
        "slug": "lmna",
        "symbol": "LMNA",
        "hgnc": "HGNC:6636",
        "name": "lamin A/C",
        "frequency": "frequent",
        "diseases": 4,
        "url": "https://dantelabs.com/genes/lmna"
      },
      {
        "slug": "pparg",
        "symbol": "PPARG",
        "hgnc": "HGNC:9236",
        "name": "peroxisome proliferator activated receptor gamma",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pparg"
      },
      {
        "slug": "smarcal1",
        "symbol": "SMARCAL1",
        "hgnc": "HGNC:11102",
        "name": "SNF2 related chromatin remodeling annealing helicase 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/smarcal1"
      },
      {
        "slug": "tgfbr3",
        "symbol": "TGFBR3",
        "hgnc": "HGNC:11774",
        "name": "transforming growth factor beta receptor 3",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tgfbr3"
      },
      {
        "slug": "thsd1",
        "symbol": "THSD1",
        "hgnc": "HGNC:17754",
        "name": "thrombospondin type 1 domain containing 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/thsd1"
      },
      {
        "slug": "wrn",
        "symbol": "WRN",
        "hgnc": "HGNC:12791",
        "name": "WRN RecQ like helicase",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/wrn"
      },
      {
        "slug": "zmpste24",
        "symbol": "ZMPSTE24",
        "hgnc": "HGNC:12877",
        "name": "zinc metallopeptidase STE24",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/zmpste24"
      },
      {
        "slug": "antxr1",
        "symbol": "ANTXR1",
        "hgnc": "HGNC:21014",
        "name": "ANTXR cell adhesion molecule 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/antxr1"
      },
      {
        "slug": "hgd",
        "symbol": "HGD",
        "hgnc": "HGNC:4892",
        "name": "homogentisate 1,2-dioxygenase",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hgd"
      },
      {
        "slug": "lcat",
        "symbol": "LCAT",
        "hgnc": "HGNC:6522",
        "name": "lecithin-cholesterol acyltransferase",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lcat"
      },
      {
        "slug": "vkorc1",
        "symbol": "VKORC1",
        "hgnc": "HGNC:23663",
        "name": "vitamin K epoxide reductase complex subunit 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/vkorc1"
      },
      {
        "slug": "agxt",
        "symbol": "AGXT",
        "hgnc": "HGNC:341",
        "name": "alanine--glyoxylate aminotransferase",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/agxt"
      },
      {
        "slug": "alms1",
        "symbol": "ALMS1",
        "hgnc": "HGNC:428",
        "name": "ALMS1 centrosome and basal body associated protein",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/alms1"
      },
      {
        "slug": "ldlrap1",
        "symbol": "LDLRAP1",
        "hgnc": "HGNC:18640",
        "name": "low density lipoprotein receptor adaptor protein 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ldlrap1"
      }
    ]
  }
}