{
  "url": "https://dantelabs.com/traits/absent-nares",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "absent-nares",
    "id": "HP:0100596",
    "name": "Missing nostrils",
    "label": "Absent nares",
    "definition": "The nostrils (the paired channels of the nose) are not present.",
    "synonyms": [
      "Abouphalia",
      "Aplasia of the nares"
    ],
    "systems": [
      {
        "slug": "abnormality-of-head-or-neck",
        "name": "Abnormality of head or neck",
        "url": "https://dantelabs.com/traits/abnormality-of-head-or-neck"
      }
    ],
    "broader": [
      {
        "slug": "abnormal-nostril-morphology",
        "name": "Abnormality of the nostrils",
        "url": "https://dantelabs.com/traits/abnormal-nostril-morphology"
      }
    ],
    "narrower": [],
    "genes": [
      {
        "slug": "otx2",
        "symbol": "OTX2",
        "hgnc": "HGNC:8522",
        "name": "orthodenticle homeobox 2",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/otx2"
      },
      {
        "slug": "prrx1",
        "symbol": "PRRX1",
        "hgnc": "HGNC:9142",
        "name": "paired related homeobox 1",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/prrx1"
      },
      {
        "slug": "smchd1",
        "symbol": "SMCHD1",
        "hgnc": "HGNC:29090",
        "name": "structural maintenance of chromosomes flexible hinge domain containing 1",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/smchd1"
      }
    ]
  }
}