{
  "url": "https://dantelabs.com/traits/absent-fingernail",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "absent-fingernail",
    "id": "HP:0001817",
    "name": "Absent fingernail",
    "definition": "Absence of a fingernail.",
    "synonyms": [
      "Aplasia of the fingernail"
    ],
    "systems": [
      {
        "slug": "abnormality-of-the-integument",
        "name": "Abnormality of the integument",
        "url": "https://dantelabs.com/traits/abnormality-of-the-integument"
      }
    ],
    "broader": [
      {
        "slug": "anonychia",
        "name": "Absent nails",
        "url": "https://dantelabs.com/traits/anonychia"
      }
    ],
    "narrower": [
      {
        "slug": "absent-thumbnail",
        "name": "Absent thumbnail",
        "genes": 23,
        "url": "https://dantelabs.com/traits/absent-thumbnail"
      },
      {
        "slug": "absent-fifth-fingernail",
        "name": "Absent fifth fingernail",
        "genes": 2,
        "url": "https://dantelabs.com/traits/absent-fifth-fingernail"
      }
    ],
    "genes": [
      {
        "slug": "dsp",
        "symbol": "DSP",
        "hgnc": "HGNC:3052",
        "name": "desmoplakin",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/dsp"
      },
      {
        "slug": "apc",
        "symbol": "APC",
        "hgnc": "HGNC:583",
        "name": "APC regulator of Wnt signaling pathway",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/apc"
      },
      {
        "slug": "atp6v1b2",
        "symbol": "ATP6V1B2",
        "hgnc": "HGNC:854",
        "name": "ATPase H+ transporting V1 subunit B2",
        "frequency": "very-frequent",
        "diseases": 3,
        "url": "https://dantelabs.com/genes/atp6v1b2"
      },
      {
        "slug": "lrp4",
        "symbol": "LRP4",
        "hgnc": "HGNC:6696",
        "name": "LDL receptor related protein 4",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lrp4"
      },
      {
        "slug": "nog",
        "symbol": "NOG",
        "hgnc": "HGNC:7866",
        "name": "noggin",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nog"
      },
      {
        "slug": "tbc1d24",
        "symbol": "TBC1D24",
        "hgnc": "HGNC:29203",
        "name": "TBC1 domain family member 24",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tbc1d24"
      },
      {
        "slug": "bcr",
        "symbol": "BCR",
        "hgnc": "HGNC:1014",
        "name": "BCR activator of RhoGEF and GTPase",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/bcr"
      },
      {
        "slug": "crkl",
        "symbol": "CRKL",
        "hgnc": "HGNC:2363",
        "name": "CRK like proto-oncogene, adaptor protein",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/crkl"
      },
      {
        "slug": "fig4",
        "symbol": "FIG4",
        "hgnc": "HGNC:16873",
        "name": "FIG4 phosphoinositide 5-phosphatase",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fig4"
      },
      {
        "slug": "jup",
        "symbol": "JUP",
        "hgnc": "HGNC:6207",
        "name": "junction plakoglobin",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/jup"
      },
      {
        "slug": "kcnh1",
        "symbol": "KCNH1",
        "hgnc": "HGNC:6250",
        "name": "potassium voltage-gated channel subfamily H member 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/kcnh1"
      },
      {
        "slug": "kcnn3",
        "symbol": "KCNN3",
        "hgnc": "HGNC:6292",
        "name": "potassium calcium-activated channel subfamily N member 3",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/kcnn3"
      },
      {
        "slug": "mapk1",
        "symbol": "MAPK1",
        "hgnc": "HGNC:6871",
        "name": "mitogen-activated protein kinase 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mapk1"
      },
      {
        "slug": "arhgap31",
        "symbol": "ARHGAP31",
        "hgnc": "HGNC:29216",
        "name": "Rho GTPase activating protein 31",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/arhgap31"
      },
      {
        "slug": "col7a1",
        "symbol": "COL7A1",
        "hgnc": "HGNC:2214",
        "name": "collagen type VII alpha 1 chain",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/col7a1"
      },
      {
        "slug": "dll4",
        "symbol": "DLL4",
        "hgnc": "HGNC:2910",
        "name": "delta like canonical Notch ligand 4",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dll4"
      },
      {
        "slug": "dock6",
        "symbol": "DOCK6",
        "hgnc": "HGNC:19189",
        "name": "dedicator of cytokinesis 6",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dock6"
      },
      {
        "slug": "eogt",
        "symbol": "EOGT",
        "hgnc": "HGNC:28526",
        "name": "EGF domain specific O-linked N-acetylglucosamine transferase",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/eogt"
      },
      {
        "slug": "notch1",
        "symbol": "NOTCH1",
        "hgnc": "HGNC:7881",
        "name": "notch receptor 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/notch1"
      },
      {
        "slug": "rbpj",
        "symbol": "RBPJ",
        "hgnc": "HGNC:5724",
        "name": "recombination signal binding protein for immunoglobulin kappa J region",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rbpj"
      },
      {
        "slug": "porcn",
        "symbol": "PORCN",
        "hgnc": "HGNC:17652",
        "name": "porcupine O-acyltransferase",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/porcn"
      }
    ]
  }
}