{
  "url": "https://dantelabs.com/traits/abnormal-toe-morphology",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "abnormal-toe-morphology",
    "id": "HP:0001780",
    "name": "Abnormalities of the toes",
    "label": "Abnormal toe morphology",
    "definition": "An anomaly of a toe.",
    "synonyms": [
      "Abnormality of toe"
    ],
    "systems": [
      {
        "slug": "abnormality-of-limbs",
        "name": "Abnormality of limbs",
        "url": "https://dantelabs.com/traits/abnormality-of-limbs"
      },
      {
        "slug": "abnormality-of-the-musculoskeletal-system",
        "name": "Abnormality of the musculoskeletal system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-musculoskeletal-system"
      }
    ],
    "broader": [
      {
        "slug": "abnormal-foot-morphology",
        "name": "Abnormal feet structure",
        "url": "https://dantelabs.com/traits/abnormal-foot-morphology"
      },
      {
        "slug": "abnormal-digit-morphology",
        "name": "Abnormality of fingers or toes",
        "url": "https://dantelabs.com/traits/abnormal-digit-morphology"
      }
    ],
    "narrower": [
      {
        "slug": "toe-syndactyly",
        "name": "Fused toes",
        "genes": 137,
        "url": "https://dantelabs.com/traits/toe-syndactyly"
      },
      {
        "slug": "sandal-gap",
        "name": "Gap between 1st and 2nd toes",
        "genes": 112,
        "url": "https://dantelabs.com/traits/sandal-gap"
      },
      {
        "slug": "foot-polydactyly",
        "name": "Duplication of bones of the toes",
        "genes": 78,
        "url": "https://dantelabs.com/traits/foot-polydactyly"
      },
      {
        "slug": "long-toe",
        "name": "Long toe",
        "genes": 30,
        "url": "https://dantelabs.com/traits/long-toe"
      },
      {
        "slug": "broad-toe",
        "name": "Broad toe",
        "genes": 16,
        "url": "https://dantelabs.com/traits/broad-toe"
      },
      {
        "slug": "slender-toe",
        "name": "Slender toe",
        "genes": 6,
        "url": "https://dantelabs.com/traits/slender-toe"
      },
      {
        "slug": "tapered-toe",
        "name": "Tapered toe",
        "genes": 4,
        "url": "https://dantelabs.com/traits/tapered-toe"
      },
      {
        "slug": "widely-spaced-toes",
        "name": "Widely spaced toes",
        "genes": 3,
        "url": "https://dantelabs.com/traits/widely-spaced-toes"
      },
      {
        "slug": "abnormal-hallux-morphology",
        "name": "Abnormality of the big toe",
        "genes": 2,
        "url": "https://dantelabs.com/traits/abnormal-hallux-morphology"
      },
      {
        "slug": "bulbous-tips-of-toes",
        "name": "Bulbous tips of toes",
        "genes": 2,
        "url": "https://dantelabs.com/traits/bulbous-tips-of-toes"
      },
      {
        "slug": "abnormal-fifth-toe-morphology",
        "name": "Abnormality of the little toe",
        "genes": 1,
        "url": "https://dantelabs.com/traits/abnormal-fifth-toe-morphology"
      },
      {
        "slug": "absent-toe-phalanx-flexion-crease",
        "name": "Absent toe phalanx flexion crease",
        "genes": 1,
        "url": "https://dantelabs.com/traits/absent-toe-phalanx-flexion-crease"
      },
      {
        "slug": "dislocation-of-toes",
        "name": "Dislocation of toes",
        "genes": 1,
        "url": "https://dantelabs.com/traits/dislocation-of-toes"
      },
      {
        "slug": "hypermobility-of-toe-joints",
        "name": "Hypermobility of toe joints",
        "genes": 1,
        "url": "https://dantelabs.com/traits/hypermobility-of-toe-joints"
      },
      {
        "slug": "toe-joint-contracture",
        "name": "Toe joint contracture",
        "genes": 1,
        "url": "https://dantelabs.com/traits/toe-joint-contracture"
      },
      {
        "slug": "abnormal-second-toe-morphology",
        "name": "Abnormal second toe morphology",
        "genes": 0,
        "url": "https://dantelabs.com/traits/abnormal-second-toe-morphology"
      },
      {
        "slug": "abnormal-third-toe-morphology",
        "name": "Abnormality of the 3rd toe",
        "genes": 0,
        "url": "https://dantelabs.com/traits/abnormal-third-toe-morphology"
      },
      {
        "slug": "abnormal-fourth-toe-morphology",
        "name": "Abnormality of the 4th toe",
        "genes": 0,
        "url": "https://dantelabs.com/traits/abnormal-fourth-toe-morphology"
      },
      {
        "slug": "abnormal-toe-epiphysis-morphology",
        "name": "Abnormality of the end part of the toe bones",
        "genes": 0,
        "url": "https://dantelabs.com/traits/abnormal-toe-epiphysis-morphology"
      },
      {
        "slug": "abnormal-toe-phalanx-morphology",
        "name": "Abnormality of the long bones of the toes",
        "genes": 0,
        "url": "https://dantelabs.com/traits/abnormal-toe-phalanx-morphology"
      },
      {
        "slug": "aplasia-hypoplasia-of-toe",
        "name": "Absent/small toe",
        "genes": 0,
        "url": "https://dantelabs.com/traits/aplasia-hypoplasia-of-toe"
      },
      {
        "slug": "deviation-of-toes",
        "name": "Deviation of toes",
        "genes": 0,
        "url": "https://dantelabs.com/traits/deviation-of-toes"
      },
      {
        "slug": "toe-deformity",
        "name": "Toe deformity",
        "genes": 0,
        "url": "https://dantelabs.com/traits/toe-deformity"
      }
    ],
    "genes": [
      {
        "slug": "atp6v1b2",
        "symbol": "ATP6V1B2",
        "hgnc": "HGNC:854",
        "name": "ATPase H+ transporting V1 subunit B2",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/atp6v1b2"
      },
      {
        "slug": "tbc1d24",
        "symbol": "TBC1D24",
        "hgnc": "HGNC:29203",
        "name": "TBC1 domain family member 24",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tbc1d24"
      },
      {
        "slug": "dyrk1a",
        "symbol": "DYRK1A",
        "hgnc": "HGNC:3091",
        "name": "dual specificity tyrosine phosphorylation regulated kinase 1A",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dyrk1a"
      },
      {
        "slug": "adnp",
        "symbol": "ADNP",
        "hgnc": "HGNC:15766",
        "name": "activity dependent neuroprotector homeobox",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/adnp"
      },
      {
        "slug": "aebp1",
        "symbol": "AEBP1",
        "hgnc": "HGNC:303",
        "name": "AE binding protein 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/aebp1"
      },
      {
        "slug": "pnkp",
        "symbol": "PNKP",
        "hgnc": "HGNC:9154",
        "name": "polynucleotide kinase 3'-phosphatase",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pnkp"
      },
      {
        "slug": "sin3a",
        "symbol": "SIN3A",
        "hgnc": "HGNC:19353",
        "name": "SIN3 transcription regulator family member A",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sin3a"
      },
      {
        "slug": "esco2",
        "symbol": "ESCO2",
        "hgnc": "HGNC:27230",
        "name": "establishment of sister chromatid cohesion N-acetyltransferase 2",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/esco2"
      },
      {
        "slug": "hras",
        "symbol": "HRAS",
        "hgnc": "HGNC:5173",
        "name": "HRas proto-oncogene, GTPase",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hras"
      },
      {
        "slug": "kras",
        "symbol": "KRAS",
        "hgnc": "HGNC:6407",
        "name": "KRas proto-oncogene, GTPase",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/kras"
      },
      {
        "slug": "nras",
        "symbol": "NRAS",
        "hgnc": "HGNC:7989",
        "name": "NRAS proto-oncogene, GTPase",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nras"
      }
    ]
  }
}