{
  "url": "https://dantelabs.com/traits/abnormal-skin-pigmentation",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "abnormal-skin-pigmentation",
    "id": "HP:0001000",
    "name": "Abnormal skin pigmentation",
    "definition": "An abnormality of the pigmentation of the skin.",
    "synonyms": [
      "Abnormal pigmentation",
      "Abnormality of pigmentation",
      "Abnormality of skin pigmentation",
      "Pigmentary changes",
      "Pigmentary skin changes",
      "Pigmentation anomaly"
    ],
    "systems": [
      {
        "slug": "abnormality-of-the-integument",
        "name": "Abnormality of the integument",
        "url": "https://dantelabs.com/traits/abnormality-of-the-integument"
      }
    ],
    "broader": [
      {
        "slug": "abnormal-skin-morphology",
        "name": "Abnormal skin structure",
        "url": "https://dantelabs.com/traits/abnormal-skin-morphology"
      }
    ],
    "narrower": [
      {
        "slug": "hyperpigmentation-of-the-skin",
        "name": "Patchy darkened skin",
        "genes": 103,
        "url": "https://dantelabs.com/traits/hyperpigmentation-of-the-skin"
      },
      {
        "slug": "hypopigmentation-of-the-skin",
        "name": "Patchy lightened skin",
        "genes": 65,
        "url": "https://dantelabs.com/traits/hypopigmentation-of-the-skin"
      },
      {
        "slug": "freckling",
        "name": "Freckling",
        "genes": 44,
        "url": "https://dantelabs.com/traits/freckling"
      },
      {
        "slug": "vitiligo",
        "name": "Blotchy loss of skin color",
        "genes": 39,
        "url": "https://dantelabs.com/traits/vitiligo"
      },
      {
        "slug": "numerous-pigmented-freckles",
        "name": "Numerous pigmented freckles",
        "genes": 13,
        "url": "https://dantelabs.com/traits/numerous-pigmented-freckles"
      },
      {
        "slug": "mottled-pigmentation",
        "name": "Mottled skin coloring",
        "genes": 8,
        "url": "https://dantelabs.com/traits/mottled-pigmentation"
      },
      {
        "slug": "reticulated-skin-pigmentation",
        "name": "Reticulated skin pigmentation",
        "genes": 6,
        "url": "https://dantelabs.com/traits/reticulated-skin-pigmentation"
      },
      {
        "slug": "periorbital-hyperpigmentation",
        "name": "Dark circles around the eyes",
        "genes": 4,
        "url": "https://dantelabs.com/traits/periorbital-hyperpigmentation"
      },
      {
        "slug": "depigmentation-hyperpigmentation-of-skin",
        "name": "Depigmentation/hyperpigmentation of skin",
        "genes": 4,
        "url": "https://dantelabs.com/traits/depigmentation-hyperpigmentation-of-skin"
      },
      {
        "slug": "blotching-pigmentation-of-the-skin",
        "name": "Blotching pigmentation of the skin",
        "genes": 2,
        "url": "https://dantelabs.com/traits/blotching-pigmentation-of-the-skin"
      },
      {
        "slug": "pigmentation-anomalies-of-sun-exposed-skin",
        "name": "Abnormal pigmentation in sun-exposed skin",
        "genes": 1,
        "url": "https://dantelabs.com/traits/pigmentation-anomalies-of-sun-exposed-skin"
      },
      {
        "slug": "fine-reticulate-skin-pigmentation",
        "name": "Fine, reticulate skin pigmentation",
        "genes": 1,
        "url": "https://dantelabs.com/traits/fine-reticulate-skin-pigmentation"
      },
      {
        "slug": "pigment-incontinence",
        "name": "Pigment incontinence",
        "genes": 1,
        "url": "https://dantelabs.com/traits/pigment-incontinence"
      },
      {
        "slug": "abnormal-dermal-melanosome-morphology",
        "name": "Abnormal dermal melanosome morphology",
        "genes": 0,
        "url": "https://dantelabs.com/traits/abnormal-dermal-melanosome-morphology"
      }
    ],
    "genes": [
      {
        "slug": "tyms",
        "symbol": "TYMS",
        "hgnc": "HGNC:12441",
        "name": "thymidylate synthetase",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tyms"
      },
      {
        "slug": "wrap53",
        "symbol": "WRAP53",
        "hgnc": "HGNC:25522",
        "name": "WD repeat containing antisense to TP53",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/wrap53"
      },
      {
        "slug": "akt1",
        "symbol": "AKT1",
        "hgnc": "HGNC:391",
        "name": "AKT serine/threonine kinase 1",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/akt1"
      },
      {
        "slug": "alk",
        "symbol": "ALK",
        "hgnc": "HGNC:427",
        "name": "ALK receptor tyrosine kinase",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/alk"
      },
      {
        "slug": "braf",
        "symbol": "BRAF",
        "hgnc": "HGNC:1097",
        "name": "B-Raf proto-oncogene, serine/threonine kinase",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/braf"
      },
      {
        "slug": "brca1",
        "symbol": "BRCA1",
        "hgnc": "HGNC:1100",
        "name": "BRCA1 DNA repair associated",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/brca1"
      },
      {
        "slug": "brca2",
        "symbol": "BRCA2",
        "hgnc": "HGNC:1101",
        "name": "BRCA2 DNA repair associated",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/brca2"
      },
      {
        "slug": "brip1",
        "symbol": "BRIP1",
        "hgnc": "HGNC:20473",
        "name": "BRCA1 interacting DNA helicase 1",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/brip1"
      },
      {
        "slug": "cav1",
        "symbol": "CAV1",
        "hgnc": "HGNC:1527",
        "name": "caveolin 1",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cav1"
      },
      {
        "slug": "ccn2",
        "symbol": "CCN2",
        "hgnc": "HGNC:2500",
        "name": "cellular communication network factor 2",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ccn2"
      },
      {
        "slug": "ccr6",
        "symbol": "CCR6",
        "hgnc": "HGNC:1607",
        "name": "C-C motif chemokine receptor 6",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ccr6"
      },
      {
        "slug": "col17a1",
        "symbol": "COL17A1",
        "hgnc": "HGNC:2194",
        "name": "collagen type XVII alpha 1 chain",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/col17a1"
      },
      {
        "slug": "cox7b",
        "symbol": "COX7B",
        "hgnc": "HGNC:2291",
        "name": "cytochrome c oxidase subunit 7B",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cox7b"
      },
      {
        "slug": "ercc4",
        "symbol": "ERCC4",
        "hgnc": "HGNC:3436",
        "name": "ERCC excision repair 4, endonuclease catalytic subunit",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ercc4"
      },
      {
        "slug": "faap100",
        "symbol": "FAAP100",
        "hgnc": "HGNC:26171",
        "name": "FA core complex associated protein 100",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/faap100"
      },
      {
        "slug": "fanca",
        "symbol": "FANCA",
        "hgnc": "HGNC:3582",
        "name": "FA complementation group A",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/fanca"
      },
      {
        "slug": "fancb",
        "symbol": "FANCB",
        "hgnc": "HGNC:3583",
        "name": "FA complementation group B",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fancb"
      },
      {
        "slug": "fancc",
        "symbol": "FANCC",
        "hgnc": "HGNC:3584",
        "name": "FA complementation group C",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fancc"
      },
      {
        "slug": "fancd2",
        "symbol": "FANCD2",
        "hgnc": "HGNC:3585",
        "name": "FA complementation group D2",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/fancd2"
      },
      {
        "slug": "fance",
        "symbol": "FANCE",
        "hgnc": "HGNC:3586",
        "name": "FA complementation group E",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fance"
      },
      {
        "slug": "fancf",
        "symbol": "FANCF",
        "hgnc": "HGNC:3587",
        "name": "FA complementation group F",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fancf"
      },
      {
        "slug": "fancg",
        "symbol": "FANCG",
        "hgnc": "HGNC:3588",
        "name": "FA complementation group G",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fancg"
      },
      {
        "slug": "fanci",
        "symbol": "FANCI",
        "hgnc": "HGNC:25568",
        "name": "FA complementation group I",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fanci"
      },
      {
        "slug": "fancl",
        "symbol": "FANCL",
        "hgnc": "HGNC:20748",
        "name": "FA complementation group L",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fancl"
      },
      {
        "slug": "fancm",
        "symbol": "FANCM",
        "hgnc": "HGNC:23168",
        "name": "FA complementation group M",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fancm"
      },
      {
        "slug": "hccs",
        "symbol": "HCCS",
        "hgnc": "HGNC:4837",
        "name": "holocytochrome c synthase",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hccs"
      },
      {
        "slug": "hgd",
        "symbol": "HGD",
        "hgnc": "HGNC:4892",
        "name": "homogentisate 1,2-dioxygenase",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hgd"
      },
      {
        "slug": "hla-drb1",
        "symbol": "HLA-DRB1",
        "hgnc": "HGNC:4948",
        "name": "major histocompatibility complex, class II, DR beta 1",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hla-drb1"
      },
      {
        "slug": "ikbkg",
        "symbol": "IKBKG",
        "hgnc": "HGNC:5961",
        "name": "inhibitor of nuclear factor kappa B kinase regulatory subunit gamma",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/ikbkg"
      },
      {
        "slug": "irf5",
        "symbol": "IRF5",
        "hgnc": "HGNC:6120",
        "name": "interferon regulatory factor 5",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/irf5"
      },
      {
        "slug": "itgb4",
        "symbol": "ITGB4",
        "hgnc": "HGNC:6158",
        "name": "integrin subunit beta 4",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/itgb4"
      },
      {
        "slug": "kiaa0319l",
        "symbol": "KIAA0319L",
        "hgnc": "HGNC:30071",
        "name": "KIAA0319 like",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/kiaa0319l"
      },
      {
        "slug": "kit",
        "symbol": "KIT",
        "hgnc": "HGNC:6342",
        "name": "KIT proto-oncogene, receptor tyrosine kinase",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/kit"
      },
      {
        "slug": "lama3",
        "symbol": "LAMA3",
        "hgnc": "HGNC:6483",
        "name": "laminin subunit alpha 3",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lama3"
      },
      {
        "slug": "lamb3",
        "symbol": "LAMB3",
        "hgnc": "HGNC:6490",
        "name": "laminin subunit beta 3",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lamb3"
      },
      {
        "slug": "lamc2",
        "symbol": "LAMC2",
        "hgnc": "HGNC:6493",
        "name": "laminin subunit gamma 2",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lamc2"
      },
      {
        "slug": "mad2l2",
        "symbol": "MAD2L2",
        "hgnc": "HGNC:6764",
        "name": "mitotic arrest deficient 2 like 2",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mad2l2"
      },
      {
        "slug": "mitf",
        "symbol": "MITF",
        "hgnc": "HGNC:7105",
        "name": "melanocyte inducing transcription factor",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mitf"
      },
      {
        "slug": "ndufb11",
        "symbol": "NDUFB11",
        "hgnc": "HGNC:20372",
        "name": "NADH:ubiquinone oxidoreductase subunit B11",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ndufb11"
      },
      {
        "slug": "nras",
        "symbol": "NRAS",
        "hgnc": "HGNC:7989",
        "name": "NRAS proto-oncogene, GTPase",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nras"
      },
      {
        "slug": "palb2",
        "symbol": "PALB2",
        "hgnc": "HGNC:26144",
        "name": "partner and localizer of BRCA2",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/palb2"
      },
      {
        "slug": "rad51",
        "symbol": "RAD51",
        "hgnc": "HGNC:9817",
        "name": "RAD51 recombinase",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rad51"
      },
      {
        "slug": "rad51c",
        "symbol": "RAD51C",
        "hgnc": "HGNC:9820",
        "name": "RAD51 paralog C",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rad51c"
      },
      {
        "slug": "raf1",
        "symbol": "RAF1",
        "hgnc": "HGNC:9829",
        "name": "Raf-1 proto-oncogene, serine/threonine kinase",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/raf1"
      },
      {
        "slug": "rfwd3",
        "symbol": "RFWD3",
        "hgnc": "HGNC:25539",
        "name": "ring finger and WD repeat domain 3",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rfwd3"
      },
      {
        "slug": "slx4",
        "symbol": "SLX4",
        "hgnc": "HGNC:23845",
        "name": "SLX4 structure-specific endonuclease subunit",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slx4"
      },
      {
        "slug": "sox5",
        "symbol": "SOX5",
        "hgnc": "HGNC:11201",
        "name": "SRY-box transcription factor 5",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sox5"
      },
      {
        "slug": "ube2t",
        "symbol": "UBE2T",
        "hgnc": "HGNC:25009",
        "name": "ubiquitin conjugating enzyme E2 T",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ube2t"
      },
      {
        "slug": "xrcc2",
        "symbol": "XRCC2",
        "hgnc": "HGNC:12829",
        "name": "X-ray repair cross complementing 2",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/xrcc2"
      },
      {
        "slug": "zeb2",
        "symbol": "ZEB2",
        "hgnc": "HGNC:14881",
        "name": "zinc finger E-box binding homeobox 2",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/zeb2"
      },
      {
        "slug": "abcd1",
        "symbol": "ABCD1",
        "hgnc": "HGNC:61",
        "name": "ATP binding cassette subfamily D member 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/abcd1"
      },
      {
        "slug": "atp2a2",
        "symbol": "ATP2A2",
        "hgnc": "HGNC:812",
        "name": "ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/atp2a2"
      },
      {
        "slug": "b4galt7",
        "symbol": "B4GALT7",
        "hgnc": "HGNC:930",
        "name": "beta-1,4-galactosyltransferase 7",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/b4galt7"
      },
      {
        "slug": "fermt1",
        "symbol": "FERMT1",
        "hgnc": "HGNC:15889",
        "name": "FERM domain containing kindlin 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fermt1"
      },
      {
        "slug": "parn",
        "symbol": "PARN",
        "hgnc": "HGNC:8609",
        "name": "poly(A)-specific ribonuclease",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/parn"
      },
      {
        "slug": "sec23a",
        "symbol": "SEC23A",
        "hgnc": "HGNC:10701",
        "name": "SEC23 homolog A, COPII component",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sec23a"
      },
      {
        "slug": "vps13b",
        "symbol": "VPS13B",
        "hgnc": "HGNC:2183",
        "name": "vacuolar protein sorting 13 homolog B",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/vps13b"
      },
      {
        "slug": "bub1",
        "symbol": "BUB1",
        "hgnc": "HGNC:1148",
        "name": "BUB1 mitotic checkpoint serine/threonine kinase",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/bub1"
      },
      {
        "slug": "bub1b",
        "symbol": "BUB1B",
        "hgnc": "HGNC:1149",
        "name": "BUB1 mitotic checkpoint serine/threonine kinase B",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/bub1b"
      },
      {
        "slug": "bub3",
        "symbol": "BUB3",
        "hgnc": "HGNC:1151",
        "name": "BUB3 mitotic checkpoint protein",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/bub3"
      },
      {
        "slug": "cep57",
        "symbol": "CEP57",
        "hgnc": "HGNC:30794",
        "name": "centrosomal protein 57",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cep57"
      },
      {
        "slug": "ddx3x",
        "symbol": "DDX3X",
        "hgnc": "HGNC:2745",
        "name": "DEAD-box helicase 3 X-linked",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ddx3x"
      },
      {
        "slug": "edar",
        "symbol": "EDAR",
        "hgnc": "HGNC:2895",
        "name": "ectodysplasin A receptor",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/edar"
      },
      {
        "slug": "edaradd",
        "symbol": "EDARADD",
        "hgnc": "HGNC:14341",
        "name": "EDAR associated via death domain",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/edaradd"
      },
      {
        "slug": "idua",
        "symbol": "IDUA",
        "hgnc": "HGNC:5391",
        "name": "alpha-L-iduronidase",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/idua"
      },
      {
        "slug": "kdf1",
        "symbol": "KDF1",
        "hgnc": "HGNC:26624",
        "name": "keratinocyte differentiation factor 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/kdf1"
      },
      {
        "slug": "lrp6",
        "symbol": "LRP6",
        "hgnc": "HGNC:6698",
        "name": "LDL receptor related protein 6",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lrp6"
      },
      {
        "slug": "proc",
        "symbol": "PROC",
        "hgnc": "HGNC:9451",
        "name": "protein C, inactivator of coagulation factors Va and VIIIa",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/proc"
      },
      {
        "slug": "pros1",
        "symbol": "PROS1",
        "hgnc": "HGNC:9456",
        "name": "protein S",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pros1"
      },
      {
        "slug": "traf6",
        "symbol": "TRAF6",
        "hgnc": "HGNC:12036",
        "name": "TNF receptor associated factor 6",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/traf6"
      },
      {
        "slug": "trip13",
        "symbol": "TRIP13",
        "hgnc": "HGNC:12307",
        "name": "thyroid hormone receptor interactor 13",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/trip13"
      },
      {
        "slug": "tsc1",
        "symbol": "TSC1",
        "hgnc": "HGNC:12362",
        "name": "TSC complex subunit 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tsc1"
      },
      {
        "slug": "tsc2",
        "symbol": "TSC2",
        "hgnc": "HGNC:12363",
        "name": "TSC complex subunit 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tsc2"
      },
      {
        "slug": "twist2",
        "symbol": "TWIST2",
        "hgnc": "HGNC:20670",
        "name": "twist family bHLH transcription factor 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/twist2"
      },
      {
        "slug": "znf699",
        "symbol": "ZNF699",
        "hgnc": "HGNC:24750",
        "name": "zinc finger protein 699",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/znf699"
      },
      {
        "slug": "col7a1",
        "symbol": "COL7A1",
        "hgnc": "HGNC:2214",
        "name": "collagen type VII alpha 1 chain",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/col7a1"
      },
      {
        "slug": "sptbn1",
        "symbol": "SPTBN1",
        "hgnc": "HGNC:11275",
        "name": "spectrin beta, non-erythrocytic 1",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sptbn1"
      },
      {
        "slug": "ercc6",
        "symbol": "ERCC6",
        "hgnc": "HGNC:3438",
        "name": "ERCC excision repair 6, chromatin remodeling factor",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ercc6"
      },
      {
        "slug": "ercc8",
        "symbol": "ERCC8",
        "hgnc": "HGNC:3439",
        "name": "ERCC excision repair 8, CSA ubiquitin ligase complex subunit",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ercc8"
      },
      {
        "slug": "flna",
        "symbol": "FLNA",
        "hgnc": "HGNC:3754",
        "name": "filamin A",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/flna"
      },
      {
        "slug": "piga",
        "symbol": "PIGA",
        "hgnc": "HGNC:8957",
        "name": "phosphatidylinositol glycan anchor biosynthesis class A",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/piga"
      },
      {
        "slug": "prkar1a",
        "symbol": "PRKAR1A",
        "hgnc": "HGNC:9388",
        "name": "protein kinase cAMP-dependent type I regulatory subunit alpha",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/prkar1a"
      },
      {
        "slug": "slco1b1",
        "symbol": "SLCO1B1",
        "hgnc": "HGNC:10959",
        "name": "solute carrier organic anion transporter family member 1B1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slco1b1"
      },
      {
        "slug": "slco1b3",
        "symbol": "SLCO1B3",
        "hgnc": "HGNC:10961",
        "name": "solute carrier organic anion transporter family member 1B3",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slco1b3"
      },
      {
        "slug": "srd5a3",
        "symbol": "SRD5A3",
        "hgnc": "HGNC:25812",
        "name": "steroid 5 alpha-reductase 3",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/srd5a3"
      },
      {
        "slug": "tubgcp6",
        "symbol": "TUBGCP6",
        "hgnc": "HGNC:18127",
        "name": "tubulin gamma complex component 6",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tubgcp6"
      },
      {
        "slug": "tyrp1",
        "symbol": "TYRP1",
        "hgnc": "HGNC:12450",
        "name": "tyrosinase related protein 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tyrp1"
      }
    ]
  }
}