{
  "url": "https://dantelabs.com/traits/abnormal-lower-limb-bone-morphology",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "abnormal-lower-limb-bone-morphology",
    "id": "HP:0040069",
    "name": "Abnormal shape of bones of the lower limbs",
    "label": "Abnormal lower limb bone morphology",
    "synonyms": [
      "Abnormality of lower limb bone",
      "Abnormal morphology of bones of the lower limbs"
    ],
    "systems": [
      {
        "slug": "abnormality-of-limbs",
        "name": "Abnormality of limbs",
        "url": "https://dantelabs.com/traits/abnormality-of-limbs"
      },
      {
        "slug": "abnormality-of-the-musculoskeletal-system",
        "name": "Abnormality of the musculoskeletal system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-musculoskeletal-system"
      }
    ],
    "broader": [
      {
        "slug": "abnormal-limb-bone-morphology",
        "name": "Abnormal shape of limb bone",
        "url": "https://dantelabs.com/traits/abnormal-limb-bone-morphology"
      },
      {
        "slug": "abnormality-of-the-lower-limb",
        "name": "Abnormality of the lower limb",
        "url": "https://dantelabs.com/traits/abnormality-of-the-lower-limb"
      }
    ],
    "narrower": [
      {
        "slug": "abnormal-femur-morphology",
        "name": "Abnormality of the thighbone",
        "genes": 41,
        "url": "https://dantelabs.com/traits/abnormal-femur-morphology"
      },
      {
        "slug": "broad-phalanx-of-the-toes",
        "name": "Wide toe bones",
        "genes": 24,
        "url": "https://dantelabs.com/traits/broad-phalanx-of-the-toes"
      },
      {
        "slug": "abnormal-tibia-morphology",
        "name": "Abnormality of the shankbone",
        "genes": 16,
        "url": "https://dantelabs.com/traits/abnormal-tibia-morphology"
      },
      {
        "slug": "abnormal-fibula-morphology",
        "name": "Abnormality of the calf bone",
        "genes": 9,
        "url": "https://dantelabs.com/traits/abnormal-fibula-morphology"
      },
      {
        "slug": "abnormal-metatarsal-morphology",
        "name": "Abnormality of the long bone of foot",
        "genes": 9,
        "url": "https://dantelabs.com/traits/abnormal-metatarsal-morphology"
      },
      {
        "slug": "abnormality-of-the-tarsal-bones",
        "name": "Abnormal ankle bones",
        "genes": 3,
        "url": "https://dantelabs.com/traits/abnormality-of-the-tarsal-bones"
      },
      {
        "slug": "osteolysis-involving-bones-of-the-lower-limbs",
        "name": "Osteolysis involving bones of the lower limbs",
        "genes": 3,
        "url": "https://dantelabs.com/traits/osteolysis-involving-bones-of-the-lower-limbs"
      },
      {
        "slug": "aplasia-hypoplasia-involving-bones-of-the-lower-limbs",
        "name": "Absent/small lower limb bones",
        "genes": 0,
        "url": "https://dantelabs.com/traits/aplasia-hypoplasia-involving-bones-of-the-lower-limbs"
      },
      {
        "slug": "duplication-involving-bones-of-the-feet",
        "name": "Duplication involving bones of the feet",
        "genes": 0,
        "url": "https://dantelabs.com/traits/duplication-involving-bones-of-the-feet"
      },
      {
        "slug": "synostosis-involving-bones-of-the-lower-limbs",
        "name": "Fusion involving the bones of the lower limbs",
        "genes": 0,
        "url": "https://dantelabs.com/traits/synostosis-involving-bones-of-the-lower-limbs"
      }
    ],
    "genes": [
      {
        "slug": "ext1",
        "symbol": "EXT1",
        "hgnc": "HGNC:3512",
        "name": "exostosin glycosyltransferase 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ext1"
      },
      {
        "slug": "ext2",
        "symbol": "EXT2",
        "hgnc": "HGNC:3513",
        "name": "exostosin glycosyltransferase 2",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ext2"
      },
      {
        "slug": "lrp5",
        "symbol": "LRP5",
        "hgnc": "HGNC:6697",
        "name": "LDL receptor related protein 5",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lrp5"
      }
    ]
  }
}